Diabetes Research and Clinical Practice
Volume 90, Issue 2 , Pages 191-195 , November 2010

No association of the SUMO4 polymorphism M55V variant in type 2 diabetes in Iranian subjects

  • Soudabeh Fallah

      Affiliations

    • Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
    • Corresponding Author InformationCorresponding author. Tel.: +98 21 88058742; fax: +98 21 88058742.
  • ,
  • Mehrzad Jafarzadeh

      Affiliations

    • Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
  • ,
  • Mehdi Hedayati

      Affiliations

    • Obesity Research Center, Research Institute For Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Received 31 October 2009 ,Revised 2 May 2010 ,Accepted 6 May 2010.

References 

  1. Ikegami H, Ogihara T. Genetics of insulin-dependent diabetes mellitus. Endocr J. 1996;43:605–613
  2. Dahlquist G, Blom L, Tuvemo T, Nystrom L, Sandstrom A, Wall S. The Swedish childhood diabetes study: results from a nine year case register and a one year case-referent study indicating that type 1 (insulin-dependent) diabetes mellitus is associated with both type 2 (non-insulin-dependent) diabetes Mellitus and autoimmune disorders. Diabetologia. 1989;32:2–6
  3. Li H, Lindholm E, Almgren P, Gustafsson A, Forsblom C, Groop L, et al. Possible human leukocyte antigen-mediated genetic interaction between type 1 and type 2 diabetes. J Clin Endocrinol Metab. 2001;86:574–582
  4. Rich SS, French LR, Sprafka JM, Clements JP, Goetz FC. HLA-associated susceptibility to type 2 (non-insulin-dependent) diabetes mellitus: the Wadena City Health Study. Diabetologia. 1993;36:234–238
  5. Tuomilehto-Wolf E, Tuomilehto J, Hitman GA, Nissinen A, Stengard J, Pekkanen J, et al. Genetic susceptibility to non-insulin dependent diabetes mellitus and glucose intolerance are located In HLA region. BMJ. 1993;307:155–159
  6. Bennett ST, Todd JA. Human type 1 diabetes and the insulin gene: principles of mapping polygenes. Annu Rev Genet. 1996;30:343–370
  7. Eftychi C, Howson JM, Barratt BJ, Vella A, Payne F, Smyth DJ, et al. Analysis of the type 2 diabetes-associated single nucleotide polymorphisms in the genes IRS1, KCNJ11, and PPARG2 in type 1 diabetes. Diabetes. 2004;53:870–873
  8. Bohren KM, Nadkarni V, Song JH, Gabbay KH, Owerbach D. A M55V Polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat Shock transcription factors and is associated with susceptibility to type I diabetes mellitus. J Biol Chem. 2004;279:27233–27238
  9. Guo D, Li M, Zhang Y, Yang P, Eckenrode S, Hopkins D, et al. A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes. Nat Genet. 2004;36:837–841
  10. Owerbach D, McKay EM, Yeh ET, Gabbay KH, Bohren KM. and Aproline-90 residue unique to SUMO-4 prevents maturation and sumoylation. Biochem Biophys Res Commun. 2005;337:517–520
  11. Bierhaus A, schiefofer s , sch warninger M, An drass y M, Hampert PM, Chen J, et al. Diabetes-associated sustained activation of the 8-transcription factor nuclear factor-κB. Diabetes. 2001;50:2792–2808
  12. Qian Y, Commane M, Ninomiya-Tsuji J, Matsumoto K, Li X. IRAK mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NF-κB. J Biol Chem. 2001;276:41661–41667
  13. Chen S, Khan ZA, Cukiernik M, Chakrabarti S. Differential activation of NF-κB and AP-1 in increased fibronectin synthesis in target organs of diabetic complications. J Am Physiol Endocrinol Metab. 2003;284(6):E1089–E1097
  14. Lee FT, Cao Z, Long DM, Anagiotopoulos S, Jerums G, Cooper ME, et al. Interactions between angiotensin II and NF-κB-dependent pathways in modulating macrophage infiltration in experimental diabetic nephropathy. J Am Soc Nephrol. 2004;15(88):2139–2151
  15. Lin SC, Lu SY, Lee SY, Lin CY, Chen CH, Chang KW. Areca (betel) nut extract activates mitogen-activated protein kinases and NF-kappaB in oral keratinocytes. J Int Cancer. 2005;116(No. 4):526–535
  16. Dai X, Yamasaki K, Shirakata Y, Sayama K, Hashimoto K. All trans-retinoic acid induces interleukin-8 via the nuclear factor-κB and p38 mitogen-activated protein kinase pathways in normal human keratinocytes. J Investig Dermatol. 2005;123:1078–1085
  17. Flindt E, Kragballe K, Henningsen J, Westergaard M, Kristiansen K, Iversen L. Inverse regulation of the nuclear factor-κB binding to the p53 and interleukin-8 κB response elements in lesional psoriatic skinclaus Johansen. J Investig Dermatol. 2005;124:1284–1292
  18. Start Key JM, Haidacher JJ, Lejiene WS, Zhang X, Tieu BC, Chouhary S, et al. Diabetes indused activation of canonical and noncanonical nuclear factor-κB-patways in renal kotex. Diabetes. 2006;55:1252–1259
  19. Bohren KM, Nadkarni V, Song JH, Gabbay KH, Owerbach . A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription factors and is associated with susceptibility to type I diabetes mellitus. J Biol Chem. 2004;279:27233–27238
  20. Takaesu G, Kishida S, Hiyama A, Yamaguchi K, Shibuya H, Irie K, et al. TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. Mol Cell. 2005;5:649–658
  21. Guo D, Li M, Zhang Y, Yang P, Eckenrode S, Hopkins D, et al. A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes. Nat Genet. 2004;36:837–841
  22. Bayer P, Arndt A, Metzger S, Mahajan R, Melchior F, Jaenicke R, et al. Structure determination of the small ubiquitin-related modifier SUMO-1. J Mol Biol. 1998;280:275–286
  23. Desterro JM, Rodriguez MS, Hay RT. SUMO-1 modification of IκB“alfa” inhibits NF-κB activation. Mol Cell. 1998;2:233–239
  24. Su H, Li S. Molecular features of human ubiquitin-like SUMO genes and their encoded proteins. Gene. 2002;296:65–73
  25. Davies JL, Cucca F, Goy JV. Saturation multipoint linkage mapping of chromosome 6q in type 1 diabetes. Hum Mol Genet. 1996;5:1071–1074
  26. Noso S, Ikegami H, Fujisawa T, Kawabata Y, Asano K, Hiromine Y, et al. Genetic heterogeneity in association of the SUMO4 M55V variant with susceptibility to type 1 diabetes. Diabetes. 2005;54(12):3582–3586
  27. Smyth DJ, Howson JMM, Lowe CE, Walker NM, Lam AC, Nutland S, et al. Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes. Nat Genet. 2005;37:110–111
  28. Noso S, Fujisawa T, Kawabata Y, Asano K, Hiromine Y, Fukai A, et al. Association of small ubiquitin-like modifier 4 (SUMO4) variant, located in IDDM5 locus, with type 2 diabetes in the Japanese population. J Clin Endocrinol Metab. 2007;92(6):2358–2362
  29. Park Y, Park S, Kang J, Yang S, Kim D. Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes. Nat Genet. 2005;37:112;author reply 112–113
  30. Silander K, Scott LJ, Valle TT, Mohlke KL, Stringham HM, Wiles KR, et al. A large set of Finnish affected sibling pair families with type 2 diabetes suggests susceptibility loci on chromosomes 6, 11, and 14. Diabetes. 2004;53:821–829
  31. Xiang K, Wang Y, Zheng T, Jia W, Li J, Chen L, et al. Genome-wide search for type 2 diabetes/impaired glucose homeostasis susceptibility genes in the Chinese: significant linkage to chromosome 6q21–q23 and chromosome 1q21–q24. Diabetes. 2004;53:228–234
  32. Sale MM, Freedman BI, Langefeld CD, Williams AH, Hicks PJ, Colicigno CJ, et al. A genome-wide scan for type 2 diabetes in African–American families reveals evidence for a locus on chromosome 6q. Diabetes. 2004;53:830–837
  33. Duggirala R, Blangero J, Almasy L, Arya R, Dyer TD, Williams KL, et al. A major locus for fasting insulin concentrations and insulin resistance on chromosome 6q with strong pleiotropic effects on obesity-related phenotypes in nondiabetic Mexican Americans. Am J Hum Genet. 2001;68:1149–1164
  34. SUMO4 gene and methods of use for type 1 diabetes – US Patent 7,173,119 claims from Patent Storm. Novel nucleic acids associated with Type 1 diabetes. US Patent Issued on February 6, 2007.
  35. Wang CY, Podolsky R, She JX. Genetic and functional evidence supporting SUMO4 as a type 1 diabetes susceptibility gene. Ann N Y Acad Sci. 2006;1079:257–267
  36. Kosoy R, Concannon P. Functional variants in SUMO4, TAB2, and NFκB and the risk of type 1 diabetes. Genes Immun. 2005;6:231235
  37. Lin H-Y, Wang C-L, Hsiao P-J, Lu Y-C, Chen S-Y, Lin K-D, et al. SUMO4 M55V variant is associated with diabetic nephropathy in type 2 diabetes. Diabetes. 2007;56:1177–1180

PII: S0168-8227(10)00322-0

doi: 10.1016/j.diabres.2010.05.033

Diabetes Research and Clinical Practice
Volume 90, Issue 2 , Pages 191-195 , November 2010