Diabetes Research and Clinical Practice
Volume 90, Issue 1 , Pages 34-39 , October 2010

Periodontal disease and risk for neuropathic foot ulceration in type 2 diabetes

  • Luciana Abrao

      Affiliations

    • Diabetes Education and Research Center, Hospital Santa Casa de Porto Alegre, Porto Alegre, Brazil
    • Graduate Program in Medical Science, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil
    • ,
  • Juliana Kliemann Chagas

      Affiliations

    • Diabetes Education and Research Center, Hospital Santa Casa de Porto Alegre, Porto Alegre, Brazil
    • Graduate Program in Medical Science, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil
    • ,
  • Helena Schmid

      Affiliations

    • Diabetes Education and Research Center, Hospital Santa Casa de Porto Alegre, Porto Alegre, Brazil
    • Graduate Program in Medical Science, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil
    • Endocrinology and Metabolism, Department of Internal Medicine, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil
    • Corresponding Author InformationCorresponding author at: Serviço de Endocrinologia, Santa Casa de Porto Alegre, Av Independência 172/701, 900070-035, Porto Alegre, RS, Brazil. Tel.: +55 051 32284055; fax: +55 051 32276720.

Received 29 November 2009 ,Revised 20 May 2010 ,Accepted 10 June 2010.

References 

  1. Albandar JM. Epidemiology and risk factors of periodontal diseases. Dent Clin North Am. 2005;49:517–532
  2. Al-Shammari KF, Al-Khabbaz AK, Al-Ansari JM, Neiva R, Wang H-L. Risk indicators for tooth loss due to periodontal disease. J Periodontol. 2005;76(1910):1913
  3. Cherry-Peppers G, Ship JA. Oral health in patients with type 2 diabetes and impaired glucose tolerance. Diabetes Care. 1993;16:638–641
  4. Oliver RC, Tervonen T. Periodontitis and tooth loss: comparing diabetics with the general population. J Am Dent Assoc. 1993;124:71–76
  5. Nelson RG, Shlossman M, Budding LM, Pettitt DJ, Saad MF, Genco RJ, et al. Periodontal disease and NIDDM in Pima Indians. Diabetes Care. 1990;13:836–840
  6. Sandberg GE, Sundberg HE, Fjellstrom CA, Wikblad KF. Type 2 diabetes and oral health—a comparison between diabetic and non diabetic subjects. Diab Res and Clin Pract. 2000;50:27–34
  7. Taylor GW. Bidirectional interrelationships between diabetes and periodontal diseases: an epidemiologic perspective. Ann Periodontol. 2001;6:99–112
  8. Katz J. Elevated blood glucose levels in patients with severe periodontal disease. J Clin Periodontol. 2001;28:710–712
  9. Löe H. Periodontal disease: the sixth complication of diabetes mellitus. Diabetes Care. 1993;16:329–334
  10. Grossi SG, Genco RJ. Periodontal disease and diabetes mellitus: a two-way relationship. Ann Periodontol. 1998;3:51–61
  11. Taylor GW. Periodontal treatment and its effects on glycemic control. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999;87:311–316
  12. Kiran M, Arpak N, Unsal E, Erdogan MF. The effect of improved periodontal health on metabolic control in type 2 diabetes mellitus. J. Clin Periodontol. 2005;32:266–272
  13. Grossi SG, Skrepcinski FB, DeCaro T, Robertson DC, Ho AW, Dunford RG, et al. Treatment of periodontal disease in diabetics reduces glycated hemoglobin. J Periodontol. 1997;68:713–719
  14. Schmidt MI, Duncan BB, Sharrett AR, Lindberg G, Savage PJ, Offenbacher S, et al. Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities Study): a cohort study. Lancet. 1999;353:1649–1652
  15. Beck JD, Offenbacher S. Systemic effects of periodontitis: epidemiology of periodontal disease and cardiovascular disease. J Periodontol. 2005;76(11 Suppl.):2089–2100
  16. Saremi A, Nelson RG, Tulloch-Reid M, Hanson RL, Sievers ML, Taylor GW, et al. Periodontal disease and mortality in type 2 diabetes. Diabetes Care. 2005;28:27–32
  17. Bloomgarden ZT, American Diabetes Association . Position Statement, the epidemiology of complications. Diabetes Care. 2002;25:924–932
  18. Lalla E, Lamster IB, Schmidt AM. Enhanced interaction of advanced glycation end products with their cellular receptor RAGE: implications for the pathogenesis of accelerated periodontal disease in diabetes. Ann Periodontol. 1998;3:13–19
  19. Lalla E, Lambster IB, Drury S, Fu C, Schimidt AM. Hyperglycemia, glycocidation, and receptor for advanced glycation end products: potential mechanisms underlying diabetic complications, including diabetes-associated periodontitis. Periodontology. 2000;23:50–62
  20. Minamoto A, Funatsu H, Yamashita H, Nakamura S, Kiriyama K, Kurihara H, et al. Relationship between periodontal disease and diabetic retinopathy. Diabetes Care. 2004;27:615
  21. Shultis WA, Weil EJ, Looker HC, Curtis JM, Shlossman M, Genco RJ, et al. Effect of periodontitis on overt nephropathy and end-stage renal disease in type 2 diabetes. Diabetes Care. 2007;30:306–311
  22. Newrick PG, Bowman C, Green D, O’Brien IAD, Porter SR, Scully C, et al. Parotid salivary secretion in diabetic autonomic neuropathy. J Diabetes Complications. 1991;5:35–37
  23. Collin HL, Niskanen L, Uusitupa M, Töyry J, Collin P, Koivisto A-M, et al. Oral symptoms and signs in elderly patients with type 2 diabetes mellitus. A focus on diabetic neuropathy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000;90:299–305
  24. Abbot C, Vileikyte L, Williamson S, Carrington A, Boulton A. Multicenter Study of the incidence of and predictive risk factor for diabetic neuropathic foot ulceration. Diabetes Care. 1998;21:1071–1075
  25. Armstrong DG, Lavery LA, Vela SA, Quebedeaux TL, Fleischli JG. Choosing a practical screening instrument to identify patients at risk for diabetic foot ulceration. Arch Intern Med. 1998;158:289–292
  26. Spierekerman CF, Hujoel PP, DeRouen TA. Bias induced by self-reported smoking on periodontitis-systemic disease associations. J Dent Res. 2003;82:345–349
  27. American Diabetes Association . Position Statement, diagnosis and classification of diabetes mellitus. Diabetes Care. 2006;29(Suppl. 1):S43–S48
  28. Mueller MJ. Identifying patients with diabetes who are at risk for lower-extremity complications: use of Semmes-Weinstein monofilaments. Phys Ther. 1996;76:68–71
  29. Bacic M, Plancak D, Granic M. CPITN assessment of periodontal status in diabetic patients. J Periodontol. 1988;59:816–822
  30. World Health Organization . Oral Health Surveys: Basic Methods. 4th ed.. Geneva: World Health Organization; 1997;
  31. Armitage GC. American Academy of Periodontology, diagnosis of periodontal diseases: research, science and therapy committee. J Periodontol. 2003;74:1237–1247
  32. Silness J, Löe H. Periodontal disease in pregnancy II: correlation between oral hygiene and periodontal conditions. Acta Odontol Scand. 1964;22:121–135
  33. International Diabetes Federation. The IDF consensus worldwide definition of the metabolic syndrome, 2006; Reference Type: Electronic Citation. Available at: http://www.idf.org/webdata/docs/IDF_Meta_def_final.pdf.
  34. Saito T, Shimazaki Y, Koga T, Tsuzuki M, Ohshima A. Relationship between upper body obesity and periodontitis. J Dent Res. 2001;80:1631–1636
  35. Pischon N, Heng N, Bernimoulin J-P, Kleber B-M, Willich SN, Pischon T Obesity. Inflammation, and periodontal disease. J Dent Res. 2007;86(5):400–409
  36. Ziegler D, Rathmann W, Dickhaus T, Meisinger C Mielck A–KORA Study Group. Prevalence of polyneuropathy in pre-diabetes and diabetes is associated with abdominal obesity and macroangiopathy. Diabetes Care. 2008;31:464–469
  37. Stanley CM, Wang Y, Pal S, Klebe RJ, Harkless LB, Xu X, et al. Fibronectin fragmentation is a feature of periodontal disease sites and diabetic foot and leg wounds and modifies cell behavior. J Periodontal. 2008;79:861–875
  38. Sandberg GE, Wikblad KF. Oral dryness and peripheral neuropathy in subjects with type 2 diabetes. J Diabetes Complications. 2003;17:192–198

PII: S0168-8227(10)00315-3

doi: 10.1016/j.diabres.2010.06.014

Diabetes Research and Clinical Practice
Volume 90, Issue 1 , Pages 34-39 , October 2010

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