Diabetes Research and Clinical Practice
Volume 90, Issue 1 , Pages 8-14 , October 2010

Newly diagnosed hyperglycemia and stress hyperglycemia in a coronary intensive care unit

  • M.E. Ertorer

      Affiliations

    • Baskent University Faculty of Medicine, Division of Endocrinology and Metabolism, Turkey
    • Corresponding Author InformationCorresponding author at: Baskent University Faculty of Medicine, Division of Endocrinology and Metabolism, Dadaloglu mah. Serinevler 39, sokak no: 6, Yuregir 01250, Adana, Turkey. Tel.: +90 322 3272727x2197/2117/2113; fax: +90 322 3271274.
  • ,
  • F.E. Haydardedeoglu

      Affiliations

    • Baskent University Faculty of Medicine, Division of Endocrinology and Metabolism, Turkey
  • ,
  • T. Erol

      Affiliations

    • Baskent University Faculty of Medicine, Department of Cardiology, Turkey
  • ,
  • I. Anaforoglu

      Affiliations

    • Baskent University Faculty of Medicine, Division of Endocrinology and Metabolism, Turkey
  • ,
  • S. Binici

      Affiliations

    • Baskent University Faculty of Medicine, Department of Cardiology, Turkey
  • ,
  • N.B. Tutuncu

      Affiliations

    • Baskent University Faculty of Medicine, Division of Endocrinology and Metabolism, Turkey
  • ,
  • A. Sezgin

      Affiliations

    • Baskent University Faculty of Medicine, Department of Cardiology, Turkey
  • ,
  • N.G. Demirag

      Affiliations

    • Baskent University Faculty of Medicine, Division of Endocrinology and Metabolism, Turkey

Received 9 March 2010 ,Accepted 20 May 2010.

References 

  1. Umpierrez GE, Isaacs SD, Bazargan N, You X, Thaler LM, Kitabchi AE. Hyperglycemia: an independent marker of in-hospital mortality in patients with undiagnosed diabetes. J Clin Endocrinol Metab. 2002;87:2978–2982
  2. Norhammar AM, Rydén L, Malmberg K. Admission plasma glucose. Independent risk factor for long-term prognosis after myocardial infarction even in nondiabetic patients. Diabetes Care. 1999;22:1827–1831
  3. McCowen KC, Malhotra A, Bistrian BR. Stress-induced hyperglycemia. Crit Care Clin. 2001;17:107–124
  4. American Diabetes Association Position Statement . Standards of medical care in diabetes. Diabetes Care. 2009;32(Suppl. 1):S42
  5. Woo E, Ma JT, Robinson JD, Yu YL. Hyperglycemia is a stress response in acute stroke. Stroke. 1988;19:1359–1364
  6. Van den Berghe G. Insulin therapy for the critically ill patient. Clin Cornerstone. 2003;5:56–63
  7. Woo J, Lam CW, Kay R, Wong AH, Teoh R, Nicholls MG. The influence of hyperglycemia and diabetes mellitus on immediate and 3-month morbidity and mortality after acute stroke. Arch Neurol. 1990;47:1174–1177
  8. Gray CS, Taylor R, French JM, Alberti KG, Venables GS, James OF, et al. The prognostic value of stress hyperglycaemia and previously unrecognized diabetes in acute stroke. Diabet Med. 1987;4:237–240
  9. Bruno A, Gregori D, Caropreso A, Lazzarato F, Petrinco M, Pagano E. Normal glucose values are associated with a lower risk of mortality in hospitalized patients. Diabetes Care. 2008;31:2209–2210
  10. Capes SE, Hunt D, Malmberg K, Gerstein HC. Stress hyperglycaemia and increased risk of death after myocardial infarction in patients with and without diabetes: a systematic overview. Lancet. 2000;355:773–778
  11. Norhammar A, Tenerz A, Nilsson G, Hamsten A, Efendíc S, Rydén L, et al. Glucose metabolism in patients with acute myocardial infarction and no previous diagnosis of diabetes mellitus: a prospective study. Lancet. 2002;359:2140–2144
  12. Anderson JL, Adams CD, Antman EM, Bridges CR, Califf RM, Casey DE, et al. ACC/AHA 2007 guidelines for the management of patients with unstable angina/non-ST-Elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction) developed in collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine. J Am Coll Cardiol. 2007;50:1–157
  13. NICE-SUGAR Study Investigators , Finfer S, Chittock DR, Su SY, Blair D, Foster D, et al Intensive versus conventional glucose control in critically ill patients. N Engl J Med. 2009;360:1283–1297
  14. Sabatine MS, Antman EM. The thrombolysis in myocardial infarction risk score in unstable angina/non-ST-segment elevation myocardial infarction. J Am Coll Cardiol. 2003;41(4 Suppl. S):S89–95
  15. Tenerz A, Lonnberg I, Berne C, Nilsson G, Leppert J. Myocardial infarction and prevalence of diabetes mellitus. Is increased casual blood glucose at admission a reliable criterion for the diagnosis of diabetes?. Eur Heart J. 2001;22:1102–1110
  16. Bolk J, van de Ploeg T, Cornel JH, Arnold AE, Sepers J, Umans VA. Impaired glucose metabolism predicts mortality after a myocardial infarction. Int J Cardiol. 2001;79:207–214
  17. Gokcel A, Ozsahin AK, Sezgin N, Karakose H, Ertorer ME, Akbaba M, et al. High prevalence of diabetes in adana; a southern province of Turkey. Diabetes Care. 2003;11:3031–3034
  18. World Health Organization. Definition and diagnosis of diabetes mellitus and intermediate hyperglycemia: report of a WHO/IDF consultation. WHO Document Production Services, Geneva; 2006; pp. 1–41.
  19. Cohn JN, Ferrari R, Sharpe N. Cardiac remodeling-concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling. Behalf of an International Forum on Cardiac Remodeling. J Am Coll Cardiol. 2000;35:569–582
  20. Rouleau JL, Packer M, Moyé L, de Champlain J, Bichet D, Klein M, et al. Prognostic value of neurohomonal activation in patients with acute myocardial infarction: effect of captopril. J Am Coll Cardiol. 1994;24:583–591
  21. Nian M, Lee P, Khaper N, Liu P. Inflamatory cytokines and postmyocardial infarction remodeling. Circ Res. 2004;94:1543–1553
  22. Saudek CD, Herman WH, Sacks DB, Bergenstal RM, Edelman D, Davidson MB. A new look at screening and diagnosing diabetes mellitus. J Clin Endocrinol Metab. 2008;93:2447–2453
  23. The International Expert Committee . The International Expert Committee report on the role of the A1c assay in the diagnosis of diabetes. Diabetes Care. 2009;32:1327–1334
  24. Selvin E, Zhu H, Brancati FL. Elevated A1c in adults without a history of diabetes in the US. Diabetes Care. 2009;32:828–833
  25. Malmberg K, Herlitz J, Hjalmarson A, Ryden L. Effects of metoprolol on mortality and late infarction in diabetics with suspected acute myocardial infarction. Retrospective data from two large studies. Eur Heart J. 1989;10:423–428

 This study is registered at www.clinicaltrials.gov with the registration # NCT00984737.

☆☆ It was presented as poster at the 45th Annual Meeting of European Association for the Study of Diabetes in Vienna on Oct. 2nd, 2009: M.E. Ertorer, F.E. Haydardedeoglu, T. Erol, I. Anaforoglu, S. Binici, N. B. Tutuncu, A. Sezgin, N.G. Demirag. “Stress hyperglycemia in a Coronary Intensive Care Unit”, Diabetologia 52: 398, Suppl. 1, 2009.

PII: S0168-8227(10)00258-5

doi: 10.1016/j.diabres.2010.05.023

Diabetes Research and Clinical Practice
Volume 90, Issue 1 , Pages 8-14 , October 2010