Diabetes Research and Clinical Practice
Volume 88, Issue 2 , Pages e14-e16, May 2010

Identification of a common autoantigenic epitope of protein disulfide isomerase, golgin-160 and voltage-gated potassium channel in type 1 diabetes

Autoimmunity and Organ Regeneration Laboratory, Children's Hospital Bambino Gesù, Research Institute (IRCCS), Piazza S. Onofrio 4, 00165 Rome, Italy

Received 12 October 2009; accepted 14 January 2010. published online 19 February 2010.

Abstract 

A common epitope of proteins golgin-160, voltage-gated potassium channel and disulfide isomerase was identified by screening with autoantibodies of a type 1 diabetic (T1D) patient a λUni-Zap cDNA library from human diabetic islets. The significance of the identified autoantigens to the disease pathogenesis remains to be elucidated.

Keywords: Type 1 diabetes, Autoantigens, Autoantibodies, Human islets cDNA libraries

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PII: S0168-8227(10)00029-X

doi:10.1016/j.diabres.2010.01.018

Diabetes Research and Clinical Practice
Volume 88, Issue 2 , Pages e14-e16, May 2010

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