Diabetes Research and Clinical Practice
Volume 88, Issue 2 , Pages 171-176, May 2010

Microinflammation is a common risk factor for progression of nephropathy and atherosclerosis in Japanese patients with type 2 diabetes

  • Nobuo Kajitani

      Affiliations

    • Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1, Shikata-cho, Okayama 700-8558, Japan
    • ,
  • Kenichi Shikata

      Affiliations

    • Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1, Shikata-cho, Okayama 700-8558, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 86 235 7233; fax: +81 86 222 5214.
    • ,
  • Akihiko Nakamura

      Affiliations

    • Department of Internal Medicine, Osafune Clinic, Okayama, Japan
    • ,
  • Tatsuaki Nakatou

      Affiliations

    • Department of Internal Medicine, Okayama Saiseikai General Hospital, Okayama, Japan
    • ,
  • Makoto Hiramatsu

      Affiliations

    • Department of Internal Medicine, Okayama Saiseikai General Hospital, Okayama, Japan
    • ,
  • Hirofumi Makino

      Affiliations

    • Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1, Shikata-cho, Okayama 700-8558, Japan

Received 10 September 2009; received in revised form 6 January 2010; accepted 11 January 2010. published online 08 February 2010.

Abstract 

Aim

This study aimed to evaluate the change of serum levels of proinflammatory molecules in patients with type 2 diabetes and clarify the involvement of these molecules in diabetic nephropathy and atherosclerosis.

Methods

Sixty-six Japanese type 2 diabetic patients (T2DM) and 39 healthy control subjects were enrolled. We assessed clinical parameters, urinary albumin excretion rate (AER), brachial-ankle pulse wave velocity (baPWV), intima media thickness (IMT) and serum levels of proinflammatory molecules.

Results

Serum levels of IL-6, IP-10 and MCP-1 were significantly higher in T2DM than in control subjects. In T2DM, serum levels of high-sensitivity (hs) CRP, IP-10, hsTNF-α, VCAM-1 and E-selectin were positively correlated with AER. Serum levels of IP-10, hsTNF-α and VCAM-1 were positively correlated with baPWV. Serum levels of hsCRP, IL-6, IP-10 and hsTNF-α were positively correlated with IMT. Multiple linear regression analysis revealed that serum levels of hsTNF-α were independently associated with AER (β=0.235, P=0.038) and serum levels of IP-10 were independently associated with baPWV (β=0.209, P=0.047) and IMT (β=0.303, P=0.032).

Conclusion

Our results suggest that low-grade inflammation, microinflammation, may be a common risk factor for diabetic nephropathy and atherosclerosis in Japanese type 2 diabetic patients.

Keywords: Microinflammation, Diabetic nephropathy, Atherosclerosis, TNF-α, IP-10

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PII: S0168-8227(10)00015-X

doi:10.1016/j.diabres.2010.01.012

Diabetes Research and Clinical Practice
Volume 88, Issue 2 , Pages 171-176, May 2010

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