Diabetes Research and Clinical Practice
Volume 88, Issue 1 , Pages 22-28 , April 2010

Automated detection of hypoglycemia-induced EEG changes recorded by subcutaneous electrodes in subjects with type 1 diabetes—The brain as a biosensor

  • Claus B. Juhl

      Affiliations

    • Medical Department, Clinic for Endocrinology and Diabetes, Sydvestjysk Sygehus Esbjerg, Denmark
    • Department of Endocrinology, Odense University Hospital, Denmark
    • Corresponding Author InformationCorresponding author at: Medical Department, Clinic for Endocrinology and Diabetes, Sydvestjysk Sygehus Esbjerg, Haraldsgade, Esbjerg 6700, Denmark. Tel.: +45 60867172; fax: +45 79182218.
    • ,
  • Kurt Højlund

      Affiliations

    • Department of Endocrinology, Odense University Hospital, Denmark
    • ,
  • Rasmus Elsborg

      Affiliations

    • Hyposafe A/S, Scion Research Park, Lyngby, Denmark
    • ,
  • Mikael Kjær Poulsen

      Affiliations

    • Department of Endocrinology, Odense University Hospital, Denmark
    • ,
  • Peter E. Selmar

      Affiliations

    • Department of Neurophysiology, Vejle Sygehus, Denmark
    • ,
  • Jens Juul Holst

      Affiliations

    • Department of Physiology, University of Copenhagen, Denmark
    • ,
  • Claus Christiansen

      Affiliations

    • Danish Research Foundation, Copenhagen and Nordic Bioscience A/S, Herlev, Denmark
    • ,
  • Henning Beck-Nielsen

      Affiliations

    • Department of Endocrinology, Odense University Hospital, Denmark

Received 25 September 2009 ,Revised 18 December 2009 ,Accepted 4 January 2010.

References 

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  2. Pedersen-Bjergaard U, Pramming S, Heller SR, Wallace TM, Rasmussen AK, Jorgensen HV, et al. Severe hypoglycemia in 1076 adult patients with type 1 diabetes: influence of risk markers and selection. Diabetes Metab. Res. Rev. 2004;20:479–486
  3. Donnelly LA, Morris AD, Frier BM, Ellis JD, Donnan PT, Durrant R, et al. Frequency and predictors of hypoglycemia in Type 1 and insulin-treated Type 2 diabetes: a population-based study. Diabet. Med. 2005;22:749–755
  4. UK Hypoglycemia Study Group. Risk of hypoglycemia in types 1 and 2 diabetes: effects of treatment modalities and their duration. Diabetologia. 2007;50:1140–1147
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  10. Tallroth G, Lindgren M, Stenberg G, Rosen I, Agardh CD. Neurophysiological changes during insulin-induced hypoglycemia and in the recovery period following glucose infusion in type 1 (insulin-dependent) diabetes mellitus and in normal man. Diabetologia. 1990;33:319–323
  11. Bendtson I, Gade J, Rosenfalck AM, Thomsen CE, Wildschiodtz G, Binder C. Nocturnal electroencephalogram registrations in type 1 (insulin-dependent) diabetic patients with hypoglycemia. Diabetologia. 1991;34:750–756
  12. Pramming S, Thorsteinsson B, Stigsby B, Binder C. Glycaemic threshold for changes in electroencephalograms during hypoglycemia in patients with insulin dependent diabetes. Br. Med. J. (Clin. Res. Ed.). 1988;296:665–667
  13. Tribl G, Howorka K, Heger G, Anderer P, Thoma H, Zeitlhofer J. EEG topography during insulin-induced hypoglycemia in patients with insulin-dependent diabetes mellitus. Eur. Neurol. 1996;36:303–309
  14. Iaione F, Marques JL. Methodology for hypoglycemia detection based on the processing, analysis and classification of the electroencephalogram. Med. Biol. Eng. Comput. 2005;43:501–507
  15. Holst JJ. Evidence that enteroglucagon (II) is identical with the C-terminal sequence (residues 33–69) of glicentin. Biochem. J. 1982;207:381–388
  16. Howorka K, Heger G, Schabmann A, Anderer P, Tribl G, Zeitlhofer J. Severe hypoglycemia unawareness is associated with an early decrease in vigilance during hypoglycemia. Psychoneuroendocrinology. 1996;21:295–312
  17. Hyllienmark L, Maltez J, Dandenell A, Ludvigsson J, Brismar T. EEG abnormalities with and without relation to severe hypoglycemia in adolescents with type 1 diabetes. Diabetologia. 2005;48:412–419
  18. Howorka K, Pumprla J, Saletu B, Anderer P, Krieger M, Schabmann A. Decrease of vigilance assessed by EEG-mapping in type I diabetic patients with history of recurrent severe hypoglycemia. Psychoneuroendocrinology. 2000;25:85–105
  19. Brismar T, Hyllienmark L, Ekberg K, Johansson BL. Loss of temporal lobe beta power in young adults with type 1 diabetes mellitus. Neuroreport. 2002;13:2469–2473

☆ ClinicalTrials.gov Identifier: NCT00810420.

PII: S0168-8227(10)00008-2

doi: 10.1016/j.diabres.2010.01.007

Diabetes Research and Clinical Practice
Volume 88, Issue 1 , Pages 22-28 , April 2010

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