Effects of short-term therapy with different insulin secretagogues on glucose metabolism, lipid parameters and oxidative stress in newly diagnosed Type 2 Diabetes Mellitus

Li, Yan; Xu, Lijuan; Shen, Jie; Ran, Jianmin; Zhang, Yang; Wang, Min; Yan, Li; Cheng, Hua; Fu, Zuzhi

doi:10.1016/j.diabres.2009.12.017

« Previous Next »Diabetes Research and Clinical Practice
Volume 88, Issue 1 , Pages 42-47, April 2010

Effects of short-term therapy with different insulin secretagogues on glucose metabolism, lipid parameters and oxidative stress in newly diagnosed Type 2 Diabetes Mellitus

Yan Li
- Department of Endocrinology and Metabology, Sun Yat-Sen Memorial Hospital, 107th Yanjiang Western Road, Guangzhou 510120, China
- Corresponding author. Tel.: +86 20 81332286; fax: +86 20 81332404.
Lijuan Xu
- Department of Endocrinology and Metabology, The Sixth Affiliated Hospital of Sun Yat-Sen University, Memorial Hospital, 107th Yanjiang Western Road, Guangzhou 510120, China
Jie Shen
- Department of Endocrinology and Metabology, Southern Hospital, Guangzhou, China
Jianmin Ran
- Department of Endocrinology and Metabology, Guangzhou Red Cross Hospital, Guangzhou, China
Yang Zhang
- Department of Endocrinology and Metabology, Guangzhou Red Cross Hospital, Guangzhou, China
Min Wang
- Department of Endocrinology and Metabology, Southern Hospital, Guangzhou, China
Li Yan
- Department of Endocrinology and Metabology, Sun Yat-Sen Memorial Hospital, 107th Yanjiang Western Road, Guangzhou 510120, China
Hua Cheng
- Department of Endocrinology and Metabology, Sun Yat-Sen Memorial Hospital, 107th Yanjiang Western Road, Guangzhou 510120, China
Zuzhi Fu
- Department of Endocrinology and Metabology, Sun Yat-Sen Memorial Hospital, 107th Yanjiang Western Road, Guangzhou 510120, China

Received 25 May 2009; received in revised form 18 November 2009; accepted 14 December 2009. published online 08 January 2010.

Abstract

Aim

To compare effects of three different insulin secretagogues on early-phase insulin secretion, metabolism of glucose and lipids, and lipid peroxidation in newly diagnosed Type 2 Diabetes Mellitus (T2DM).

Methods

Totally 60 newly diagnosed T2DM outpatients were randomized to three groups with 1-month monotherapy of repaglinide (Rg), glimepiride (Gm) or gliclazide MR (Gli), respectively. Some indexes of early-phase insulin secretion, glucose, lipids, and lipid peroxidation were inspected.

Results

Fasting plasma glucose (FPG), glycosylated hemoglobin (HbA_1c) and fructosamine (FA) were improved in all groups similarly (p>0.05). Rg group was with the highest early-phase insulin secretion index (ΔI30/ΔG30) (p=0.026), lower mean amplitude of glycaemic excursion (MAGE) (p<0.05), lowest mean peak value of post-lunch glucose (p=0.043), and lowest postprandial triglyceride (TG) (p=0.039). Postprandial free fatty acid (FFA) was lower after Rg and Gli treatment (p<0.05). Serum 8-iso prostaglandin F_2α (8-iso PGF_2α) was improved in all groups, but the improvement showed statistically significant only in Rg group (p=0.04).

Conclusion

Rg, Gm and Gli can all decrease blood glucose effectively in newly diagnosed T2DM patients, while Rg performs outstandingly in the aspects of improving early-phase insulin secretion, glucose excursion, postprandial lipids and 8-iso PGF_2α.

Keywords: Insulin secretagogue, Glucose excursion, Early-phase insulin secretion, Oxidative stress