Diabetes Research and Clinical Practice
Volume 87, Issue 3 , Pages 385-393 , March 2010

Comorbidity in the elderly with diabetes: Identification of areas of potential treatment conflicts

  • Gillian E. Caughey

      Affiliations

    • Quality Use of Medicines and Pharmacy Research Centre, Sansom Institute, School of Pharmacy and Medical Sciences, University of South Australia, Australia
    • Corresponding Author InformationCorresponding author at: Quality Use of Medicines and Pharmacy Research Centre, Sansom Institute, School of Pharmacy and Medical Sciences, University of South Australia, GPO Box 2471, Adelaide 5001, Australia. Tel.: +61 8 8302 1749; fax: +61 8 8302 1087.
    • ,
  • Elizabeth E. Roughead

      Affiliations

    • Quality Use of Medicines and Pharmacy Research Centre, Sansom Institute, School of Pharmacy and Medical Sciences, University of South Australia, Australia
    • ,
  • Agnes I. Vitry

      Affiliations

    • Quality Use of Medicines and Pharmacy Research Centre, Sansom Institute, School of Pharmacy and Medical Sciences, University of South Australia, Australia
    • ,
  • Robyn A. McDermott

      Affiliations

    • Division of Health Sciences, University of South Australia, Australia
    • ,
  • Sepehr Shakib

      Affiliations

    • Department of Clinical Pharmacology, Royal Adelaide Hospital and Department of Clinical Pharmacology, University of Adelaide, Australia
    • ,
  • Andrew L. Gilbert

      Affiliations

    • Quality Use of Medicines and Pharmacy Research Centre, Sansom Institute, School of Pharmacy and Medical Sciences, University of South Australia, Australia

Received 29 June 2009 ,Revised 13 October 2009 ,Accepted 26 October 2009.

References 

  1. Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004;27:1047–1053
  2. Wolff JL, Starfield B, Anderson G. Prevalence, Expenditures, and complications of multiple chronic conditions in the elderly. Arch. Intern. Med. 2002;162:2269–2276
  3. Britt HC, Harrison CM, Miller GC, Knox SA. Prevalence and patterns of multimorbidity in Australia. Med. J. Aust. 2008;189:72–77
  4. Weiss CO, Boyd CM, Yu Q, Wolff JL, Leff B. Patterns of prevalent major chronic disease among older adults in the United States. JAMA. 2007;298:1160–1162
  5. Kerr EA, Heisler M, Krein SL, Kabeto M, Langa KM, Weir D, et al. Beyond comorbidity counts: how do comorbidity type and severity influence diabetes patients’ treatment priorities and self-management?. J. Gen. Intern. Med. 2007;22:1635–1640
  6. Halanych JH, Safford MM, Keys WC, Person SD, Shikany JM, Kim Y-I, et al. Burden of comorbid medical conditions and quality of diabetes care. Diabetes Care. 2007;30:2999–3004
  7. Howard BV, Best LG, Galloway JM, Howard WJ, Jones K, Lee ET, et al. Coronary heart disease risk equivalence in diabetes depends on concomitant risk factors. Diabetes Care. 2006;29:391–397
  8. Piette JD, Kerr EA. The impact of comorbid chronic conditions on diabetes care. Diabetes Care. 2006;29:725–731
  9. Durso SC. Using clinical guidelines designed for older adults with diabetes mellitus and complex health status. JAMA. 2006;295:1935–1940
  10. California Healthcare Foundation/American Geriatrics Society Panel in Improving Care for Elders with Diabetes, Guidelines for improving the care of the older person with diabetes mellitus, J. Am. Geriatr. Soc. 51 (2003) 265–280.
  11. Ciechanowski PS, Katon WJ, Russo JE. Depression and diabetes: impact of depressive symptoms on adherence, function, and costs. Arch. Intern. Med. 2000;160:3278–3285
  12. Miksch A, Hermann K, Rolz A, Joos S, Szecsenyi J, Ose D, et al. Additional impact of concomitant hypertension and osteoarthritis on quality of life among patients with type 2 diabetes in primary care in Germany—a cross-sectional survey. Health Qual Life Outcomes. 2009;7:19
  13. Rollason V, Vogt N. Reduction of polypharmacy in the elderly: a systematic review of the role of the pharmacist. Drugs Aging. 2003;20:817–832
  14. Milton JC, Hill-Smith I, Jackson SH. Prescribing for older people. BMJ. 2008;336:606–609
  15. World Health Organization International Classification of Diseases, International Statistical Classification of Diseases and Related Health Problems, 10th revision, vol. 2008, 2007.
  16. Australian Government Department of Health and Ageing, Schedule of pharmaceutical benefits. PBS for Health Professionals, http://www.pbs.gov.au/html/healthpro/home (accessed August 2008), 2008.
  17. Australian Bureau of Statistics, 2001 Census of Population and Housing—SEIFA 2001, 2001.
  18. Australian Centre for Diabetes Strategies, For the Diabetes Australia Guideline Development Consortium. National evidence based guidelines for the management of type 2 diabetes mellitus, http://www.nhmrc.gov.au/publications/synopses/di7todi13syn.htm (accessed Jan 2009). National Health and Medical Research Council: Canberra, Australia 2005.
  19. Vitry AI, Wong SA, Roughead EE, Ramsay E, Barratt J. Validity of medication-based comorbidity indices in the Australian elderly population Australian and New Zealand. J. Public Health. 2009;33:126–130
  20. Caughey GE, Vitry AI, Gilbert AL, Roughead EE. Prevalence of comorbidity of chronic diseases in Australia. BMC Public Health. 2008;8:221–233
  21. Endocrinology Expert Group . Therapeutic Guidelines: Endocrinology, Version 5. Victoria, Australia: Therapeutic Guidelines Limited; 2004;
  22. Australian Medicines Handbook . Australian Medicines Handbook. Australian Medicines Handbook Pty. Ltd.; 2009;
  23. Nisbet Janelle C, Sturtevant Joanna M, Prins Johannes B. Metformin and serious adverse effects. MJA. 2004;180:53–54
  24. Graal MB, Wolffenbuttel BH. The use of sulphonylureas in the elderly. Drugs Aging. 1999;15:471–481
  25. Yki-Jarvinen H. Thiazolidinediones. N. Engl. J. Med. 2004;351:1106–1118
  26. van der Woude HJ, Zaagsma J, Postma DS, Winter TH, van Hulst M, Aalbers R. Detrimental effects of beta-blockers in COPD: a concern for nonselective beta-blockers. Chest. 2005;127:818–824
  27. Michael J, Abramson , Alan JC, Peter A, Frith , Christine F, et al. COPDX: an update of guidelines for the management of chronic obstructive pulmonary disease with a review of recent evidence. MJA. 2006;184:342–345
  28. Slatore CG, Bryson CL, Au DH. The association of inhaled corticosteroid use with serum glucose concentrations in a large cohort. Am. J. Med. 2009;122:472–478
  29. Consuelo Huerta , Jordi Castellsague , Cristina Varas-Lorenzo , Luis Alberto GarcÃa RodrÃguez . Nonsteroidal anti-inflammatory drugs and risk of ARF in the general population. Am. J. Kidney Dis. 2005;45:531–539
  30. Roughead EE, Ramsay E, Pratt N, Gilbert AL. NSAID use in individuals at risk of renal adverse events: an observational study to investigate trends in Australian veterans. Drug Saf. 2008;31:997–1003
  31. Beers MH. Explicit criteria for determining potentially inappropriate medication use by the elderly. Arch. Intern. Med. 1997;157:1531–1536
  32. Fick DM, Cooper JW, Wade WE, Waller JL, Maclean JR, Beers MH. Updating the beers criteria for potentially inappropriate medication use in older adults: results of a US consensus panel of experts. Arch. Intern. Med. 2003;163:2716–2724
  33. Pogach LM, Tiwari A, Maney M, Rajan M, Miller DR, Aron D. Should mitigating comorbidities be considered in assessing healthcare plan performance in achieving optimal glycemic control?. Am. J. Manag. Care. 2007;13:133–140
  34. Salpeter SR, Greyber E, Pasternak GA, Salpeter EE. Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus: systematic review and meta-analysis. Arch, Intern. Med. 2003;163:2594–2602
  35. Page J, Henry D. Consumption of NSAIDs and the development of congestive heart failure in elderly patients: an underrecognized public health problem. Arch. Intern. Med. 2000;160:777–784
  36. Garcia Rodríguez LA, Hernández-Díaz S. The risk of upper gastrointestinal complications associated with nonsteroidal anti-inflammatory drugs, glucocorticoids, acetaminophen, and combinations of these agents. Arthritis Res. 2001;3:98–101
  37. Rabe KF, Hurd S, Anzueto A, Barnes PJ, Buist SA, Calverley P, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am. J. Respir. Crit. Care Med. 2007;176:532–555
  38. Ray KK, Seshasai SRK, Wijesuriya S, Sivakumaran R, Nethercott S, Preiss D, et al. Effect of intensive control of glucose on cardiovascular outcomes and death in patients with diabetes mellitus: a meta-analysis of randomised controlled trials. The Lancet. 2009;373:1765–1772
  39. Erdmann E. Safety and tolerability of beta-blockers: prejudices and reality. Eur. Heart J. Suppl. 2009;11:A21–25
  40. Salpeter SR, Ormiston TM, Salpeter EE. Cardioselective β-blockers in patients with reactive airway disease: a meta-analysis. Ann. Intern. Med. 2002;137:715–725
  41. Dransfield MT, Rowe SM, Johnson JE, Bailey WC, Gerald LB. Use of {beta} blockers and the risk of death in hospitalised patients with acute exacerbations of COPD. Thorax. 2008;63:301–305
  42. Roughead EE, Anderson B, Gilbert AL. Potentially inappropriate prescribing amongst Australian veterans and war widows/widowers. IMJ.
  43. van der Hooft CS, Jong GW, Dieleman JP, Verhamme KM, van der Cammen TJ, Stricker BH, et al. Inappropriate drug prescribing in older adults: the updated 2002 Beers criteria—a population-based cohort study. Br. Clin. Pharm. 2005;60:137–144
  44. Jano Elda, Aparasu Rajender R. Healthcare outcomes associated with Beers’ criteria: a systematic review. Ann. Pharmacother. 2007;41:438–447
  45. Budnitz DS, Shehab N, Kegler SR, Richards CL. Medication use leading to emergency department visits for adverse drug events in older adults. Ann. Intern. Med. 2007;147:755–765
  46. Steinman MA, Rosenthal GE, Landefeld CS, Bertenthal D, Kaboli PJ. Agreement between drugs-to-avoid criteria and expert assessments of problematic prescribing. Arch. Intern. Med. 2009;169:1326–1332

PII: S0168-8227(09)00467-7

doi: 10.1016/j.diabres.2009.10.019

Diabetes Research and Clinical Practice
Volume 87, Issue 3 , Pages 385-393 , March 2010

Article Tools

* Image Usage & Resolution