Diabetes Research and Clinical Practice
Volume 87, Issue 2 , Pages 176-183 , February 2010

Plasma apelin levels and apelin/APJ mRNA expression in patients with gestational diabetes mellitus

  • Beata Telejko

      Affiliations

    • Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, , Poland
    • Corresponding Author InformationCorresponding author at: Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, M. Curie-Skłodowskiej 24A, 15-276 Białystok, Poland. Tel.: +48 857468239; fax: +48 857447611.
  • ,
  • Mariusz Kuzmicki

      Affiliations

    • Department of Gynecology, Medical University of Bialystok, , Poland
  • ,
  • Natalia Wawrusiewicz-Kurylonek

      Affiliations

    • Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, , Poland
  • ,
  • Jacek Szamatowicz

      Affiliations

    • Department of Gynecology, Medical University of Bialystok, , Poland
  • ,
  • Agnieszka Nikolajuk

      Affiliations

    • Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, , Poland
  • ,
  • Anna Zonenberg

      Affiliations

    • Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, , Poland
  • ,
  • Dorota Zwierz-Gugala

      Affiliations

    • Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, , Poland
  • ,
  • Wojciech Jelski

      Affiliations

    • Department of Biochemical Diagnostics, Medical University of Bialystok, , Poland
  • ,
  • Piotr Laudański

      Affiliations

    • Department of Gynecology, Medical University of Bialystok, , Poland
  • ,
  • Jan Wilczynski

      Affiliations

    • Foetal-Maternal Medicine and Gynecology Department, Research Institute Polish Mother's Memorial Hospital (RI PMMH), Lodz, Poland
  • ,
  • Adam Kretowski

      Affiliations

    • Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, , Poland
  • ,
  • Maria Gorska

      Affiliations

    • Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, , Poland

Received 10 June 2009 ,Revised 5 October 2009 ,Accepted 26 October 2009.

References 

  1. Tatemoto K, Hosoya M, Habata Y, Fujii R, Kakegawa T, Zou MX, et al. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem. Biophys. Res. Commun. 1998;251:471–476
  2. Lee DK, Cheng R, Nguyen T. Characterization of apelin, the ligand for the APJ receptor. J. Neurochem. 2000;74:34–41
  3. O’Carroll AM, Selby TL, Palkovits M, Lolait SJ. Distribution of mRNA encoding B78/apj, the rat homologue of the human APJ receptor, and its endogenous ligand apelin in brain and peripheral tissues. Biochim. Biophys. Acta. 2000;1492:72–80
  4. Kawamata Y, Habata Y, Fukusumi S, Hosoya M, Fujii R, Hinuma S, et al. Molecular properties of apelin: tissue distribution and receptor binding. Biochim. Biophys. Acta. 2001;1538:162–171
  5. De Falco M, De Luca L, Onori N, Cavallotti I, Artigiano F, Esposito V, et al. Apelin expression in normal human tissues. In Vivo. 2002;16:333–336
  6. Medhurst AD, Jennings CA, Robbins MJ, Davis RP, Ellis C, Winborn KY, et al. Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin. J. Neurochem. 2003;84:1162–1172
  7. Cobellis L, De Falco M, Mastrogiacomo A, Giraldi D, Dattilo D, Scaffa C, et al. Modulation of apelin and APJ receptor in normal and preeclampsia-complicated placentas. Histol. Histopathol. 2007;22:1–8
  8. Kleinz MJ, Davenport AP. Immunocytochemical localization of the endogenous vasoactive peptide apelin to human vascular and endocardial endothelial cells. Regul. Pept. 2004;118:119–125
  9. Falcao-Pires I, Leite-Moreira AF. Apelin: a novel neurohumoral modulator of the cardiovascular system: pathophysiologic importance and potential use as a therapeutic target. Rev. Port. Cardiol. 2005;24:1263–1276
  10. Tatemoto K, Takayama K, Zou MX, Kumaki I, Zhang W, Kumano K, et al. The novel peptide apelin lowers blood pressure via a nitric oxide-dependent mechanism. Regul. Pept. 2001;99:87–92
  11. Szokodi I, Tavi P, Foldes G, Voutilainen-Myllyla S, Ilves M, Tokola H, et al. Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility. Circ. Res. 2002;91:434–440
  12. Chen MM, Ashley EA, Deng DX, Tsalenko A, Deng A, Tabibiazar R, et al. Novel role for the potent endogenous inotrope apelin in human cardiac dysfunction. Circulation. 2003;108:1432–1439
  13. Ishida J, Hashimoto T, Hashimoto Y, Nishiwaki S, Iguchi T, Harada S, et al. Regulatory roles for APJ, a seven-transmembrane receptor related to AT1, in blood pressure in vivo. J. Biol. Chem. 2004;279:26274–26279
  14. Cheng X, Cheng XS, Pang CC. Venous dilator effect of apelin, an endogenous peptide ligand for the orphan APJ, receptor in conscious rats. Eur. J. Pharmacol. 2003;470:171–175
  15. Ashley EA, Powers J, Chen M, Kundu R, Finsterbach T, Caffarelli A, et al. The endogenous peptide apelin potently improves cardiac contractility and reduces cardiac loading in vivo. Cardiovasc. Res. 2005;65:73–82
  16. Taheri S, Murphy K, Cohen M, Sujkovic E, Kennedy A, Dhillo W, et al. The effects of centrally administered apelin-13 on food intake, water intake and pituitary hormone release in rats. Biochem. Biophys. Res. Commun. 2002;291:1208–1212
  17. De Mota N, Reaux A, Messari SE, Chartrel N, Roesch D, Dujardin C, et al. Apelin, a potent diuretic neuropeptide counteracting vasopressin actions through inhibition of vasopressin neuron activity and vasopressin. Proc. Natl. Acad. Sci. USA. 2004;101:10464–10469
  18. Masri B, Morin N, Cornu M, Knibiehler B, Audigier Y. Apelin (65–77) activates p70 S6 kinase and is mitogenic for umbilical endothelial cells. FASEB J. 2004;18:1909–1911
  19. Saint-Geniez M, Argence CB, Knibiehler B, Audigier Y. The msr/apj gene encoding the apelin receptor is an early and specific marker of the venous phenotype in the retinal vasculature. Gene Expression Patterns. 2003;3:467–472
  20. Boucher J, Masri B, Daviaud D, Gesta S, Guigne C, Mazzucotelli A, et al. Apelin, a newly identified adipokine up-regulated by insulin and obesity. Endocrinology. 2005;146:1764–1771
  21. Wei L, Hou X, Tatemoto K. Regulation of apelin mRNA expression by insulin and glucocorticoids in mouse 3T3-L1 adipocytes. Regul. Pept. 2005;132:27–32
  22. Dray C, Knauf C, Daviaud D, Waget A, Boucher J, Buléon M, et al. Apelin stimulates glucose utilization in normal and obese insulin-resistant mice. Cell Metab. 2008;8:437–445
  23. Castan-Laurell I, Vítkova M, Daviaud D, Dray C, Kovacikova M, Kovacova Z, et al. Effect of hypocaloric diet-induced weight loss in obese women on plasma apelin and adipose tissue expression of apelin and APJ. Eur. J. Endocrinol. 2008;158:905–910
  24. Heinonen MV, Purhonen AK, Miettinen P, Paakkonen M, Pirinen E, Alhava E, et al. Apelin, orexin-A and leptin plasma levels in morbid obesity and effect of gastric banding. Regul. Pept. 2005;130:7–13
  25. Li L, Yang G, Li Q, Tang Y, Yang M, Yang H, et al. Changes and relations of circulating visfatin, apelin, and resistin levels in normal, impaired glucose tolerance, and type 2 diabetic subjects. Exp. Clin. Endocrinol. Diabetes. 2006;114:544–548
  26. Erdem G, Dogru T, Tasci I, Sonmez A, Tapan S. Low plasma apelin levels in newly diagnosed type 2 diabetes mellitus. Exp. Clin. Endocrinol. Diabetes. 2008;116:289–292
  27. Barbour LA, McCurdy CE, Hernandez TL, Kirwan JP, Catalano PM, Friedman JE. Cellular mechanisms for insulin resistance in normal pregnancy and gestational diabetes. Diabetes Care. 2007;30(Suppl. 2):S112–S119
  28. WHO Consultation. Definition, diagnosis, and classification of diabetes mellitus and its complications. Report of a WHO consultation. Part 1: Diagnosis and classification of diabetes mellitus, WHO/NCD/NCS/99.2, WHO, Geneva, 1999.
  29. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. Clin. Chem. 1972;18:499–502
  30. Iwanaga Y, Kihara Y, Takenaka H, Kita T. Down-regulation of cardiac apelin system in hypertrophied and failing hearts: possible role of angiotensin II–angiotensin type 1 receptor system. J. Mol. Cell. Cardiol. 2006;41:798–806
  31. Atluri P, Morine KJ, Liao GP, Panlilio CM, Berry MF, Hsu VM, et al. Ischemic heart failure enhances endogenous myocardial apelin and APJ receptor expression. Cell. Mol. Biol. Lett. 2007;12:127–138
  32. Rosenfeld CR. Mechanisms regulating angiotensin II responsiveness by the uteroplacental circulation. Am. J. Physiol. 2001;281:R1025–R1040
  33. Williams DJ, Vallance PJ, Neild GH, Spencer JA, Imms FJ. Nitric oxide-mediated vasodilation in human pregnancy. Am. J. Physiol. 1997;272:H748–H752
  34. O’Dowd BF, Heiber M, Chan A, Heng HH, Tsui LC, Kennedy JL, et al. A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11. Gene. 1993;136:355–360
  35. Vickers C, Hales P, Kaushik V, Dick L, Gavin J, Tang J, et al. Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase. J. Biol. Chem. 2002;277:14838–14843
  36. Daviaud D, Boucher J, Gesta S, Dray C, Guigne C, Quilliot D, et al. TNF-α up-regulates apelin expression in human and mouse adipose tissue. FASEB J. 2006;20:1528–1530
  37. Telejko B, Kuzmicki M, Zonenberg A, Szamatowicz J, Wawrusiewicz-Kurylonek N, Nikolajuk A, et al. Visfatin in gestational diabetes: serum level and mRNA expression in fat and placental tissue. Diab. Res. Clin. Pract. 2009;84:68–75
  38. Worda C, Leipold H, Gruber C, Kautzky-Willer A, Knöfler M, Bancher-Todesca D. Decreased plasma adiponectin concentrations in women with gestational diabetes. Am. J. Obstet. Gynecol. 2004;191:2120–2124
  39. Cortelazzi D, Corbetta S, Ronzoni S, Pelle F, Marconi A, Cozzi V, et al. Maternal and foetal resistin and adiponectin concentrations in normal and complicated pregnancies. Clin. Endocrinol. 2007;66:447–453
  40. Williams MA, Qiu C, Muy-Rivera M, Vadachkoria S, Son T, Luthy DA. Plasma adiponectin concentrations in early pregnancy and subsequent risk of gestational diabetes mellitus. J. Clin. Endocrinol. Metab. 2004;89:2306–2611
  41. Caminos JE, Nogueiras R, Gallego R, Bravo S, Tovar S, Garcia-Caballero T, et al. Expression and regulation of adiponectin and receptor in human and rat placenta. J. Clin. Endocrinol. Metab. 2005;90:4276–4286
  42. Chen J, Tan B, Karteris E, Zervou S, Digby F , Hillhouse W, et al. Secretion of adiponectin by human placenta: differential modulation of adiponectin and its receptors by cytokines. Diabetologia. 2006;49:1292–1302
  43. Corbetta S, Bulfamante G, Cortelazzi D, Barresi V, Cetin I, Mantovani G, et al. Adiponectin expression in human fetal tissues during mid- and late-gestation. J. Clin. Endocrinol. Metab. 2004;90:2397–2402
  44. Haugen F, Ranheim T, Harsem NK, Lips E, Staff AC, Drevon CA. Increased plasma levels of adipokines in preeclampsia: relationship to placenta and adipose tissue gene expression. Am. J. Physiol. Endocrinol. Metab. 2005;290:E326–E333
  45. Meller M, Qiu C, Vadachkoria S, Abetew DF, Luthy DA, Williams MA. Changes in placental adipocytokine gene expression associated with gestational diabetes mellitus. Physiol. Res. 2006;55:501–512

 The study was supported by grant no. KBN 2 PO5E 08829 from the State Committee for Scientific Research.

PII: S0168-8227(09)00466-5

doi: 10.1016/j.diabres.2009.10.018

Diabetes Research and Clinical Practice
Volume 87, Issue 2 , Pages 176-183 , February 2010