Diabetes Research and Clinical Practice
Volume 87, Issue 1 , Pages 57-63 , January 2010

Macrophage foam cell formation is augmented in serum from patients with diabetic angiopathy

  • Xinglong Cui

      Affiliations

    • Department of Medical Chemistry, Division of Molecular Medical Science, Graduate School of Biomedical Science, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima, Japan
  • ,
  • Akifumi Kushiyama

      Affiliations

    • The Institute for Adult Diseases, Asahi Life Foundation, 1-6-1 Marunouchi, Chiyoda-ku, Tokyo, Japan
  • ,
  • Masayasu Yoneda

      Affiliations

    • Department of Medical Chemistry, Division of Molecular Medical Science, Graduate School of Biomedical Science, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima, Japan
  • ,
  • Yusuke Nakatsu

      Affiliations

    • Department of Medical Chemistry, Division of Molecular Medical Science, Graduate School of Biomedical Science, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima, Japan
  • ,
  • Ying Guo

      Affiliations

    • Department of Medical Chemistry, Division of Molecular Medical Science, Graduate School of Biomedical Science, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima, Japan
  • ,
  • Jun Zhang

      Affiliations

    • Department of Medical Chemistry, Division of Molecular Medical Science, Graduate School of Biomedical Science, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima, Japan
  • ,
  • Haruya Ono

      Affiliations

    • Department of Medical Chemistry, Division of Molecular Medical Science, Graduate School of Biomedical Science, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima, Japan
  • ,
  • Machi Kanna

      Affiliations

    • Department of Medical Chemistry, Division of Molecular Medical Science, Graduate School of Biomedical Science, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima, Japan
  • ,
  • Hideyuki Sakoda

      Affiliations

    • Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan
  • ,
  • Hiraku Ono

      Affiliations

    • Department of Medicine, Diabetes Research Center, Albert Einstein College of Medicine, New York, NY, USA
  • ,
  • Takako Kikuchi

      Affiliations

    • The Institute for Adult Diseases, Asahi Life Foundation, 1-6-1 Marunouchi, Chiyoda-ku, Tokyo, Japan
  • ,
  • Midori Fujishiro

      Affiliations

    • Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan
  • ,
  • Masashi Shiomi

      Affiliations

    • Institute for Experimental Animals, Kobe University School of Medicine, Kobe, Hyogo, Japan
  • ,
  • Hideaki Kamata

      Affiliations

    • Department of Medical Chemistry, Division of Molecular Medical Science, Graduate School of Biomedical Science, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima, Japan
  • ,
  • Hiroki Kurihara

      Affiliations

    • Physiological Chemistry and Metabolism, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan
  • ,
  • Masatoshi Kikuchi

      Affiliations

    • The Institute for Adult Diseases, Asahi Life Foundation, 1-6-1 Marunouchi, Chiyoda-ku, Tokyo, Japan
  • ,
  • Shoji Kawazu

      Affiliations

    • The Institute for Adult Diseases, Asahi Life Foundation, 1-6-1 Marunouchi, Chiyoda-ku, Tokyo, Japan
  • ,
  • Fusanori Nishimura

      Affiliations

    • Department of Dental Science for Health Promotion, Division of Cervico-Gnathostomatology, Graduate School of Biomedical Sciences, Hiroshima University, Japan
  • ,
  • Tomoichiro Asano

      Affiliations

    • Department of Medical Chemistry, Division of Molecular Medical Science, Graduate School of Biomedical Science, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 332016781; fax: +81 332016881.

Received 3 April 2009 ,Revised 18 October 2009 ,Accepted 22 October 2009.

References 

  1. Tesch . Role of macrophages in complications of type 2 diabetes. Clin. Exp. Pharmacol. Physiol. 2007;34:1016–1019
  2. Nguyen , Ping , Mu , Hill , Atkins , Chadban . Macrophage accumulation in human progressive diabetic nephropathy. Nephrology (Carlton). 2006;11:226–231
  3. Boyle . Diabetes mellitus and macrovascular disease: mechanisms and mediators. Am. J. Med. 2007;120:S12–17
  4. Simionescu . Implications of early structural-functional changes in the endothelium for vascular disease. Arterioscler. Thromb. Vasc. Biol. 2007;27:266–274
  5. Gacka , Dobosz , Szymaniec , Bednarska-Chabowska , Adamiec , Sadakierska-Chudy . Proinflammatory and atherogenic activity of monocytes in Type 2 diabetes. J. Diabetes Complications. 2008;
  6. Hodgkinson , Laxton , Patel , Ye . Advanced glycation end-product of low density lipoprotein activates the toll-like 4 receptor pathway implications for diabetic atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 2008;28:2275–2281
  7. Ishigaki , Katagiri , Gao , Yamada , Imai , Uno , et al. Impact of plasma oxidized low-density lipoprotein removal on atherosclerosis. Circulation. 2008;118:75–83
  8. Mori , Itabe , Higashi , Fujimoto , Shiomi , Yoshizumi , et al. Foam cell formation containing lipid droplets enriched with free cholesterol by hyperlipidemic serum. J. Lipid Res. 2001;42:1771–1781
  9. Shiomi , Ito , Yamada , Kawashima , Fan . Development of an animal model for spontaneous myocardial infarction (WHHLMI rabbit). Arterioscler. Thromb. Vasc. Biol. 2003;23:1239–1244
  10. Tanzawa , Shimada , Kuroda , Tsujita , Arai , Watanabe . WHHL-rabbit: a low density lipoprotein receptor-deficient animal model for familial hypercholesterolemia. FEBS Lett. 1980;118:81–84
  11. Buja , Kita , Goldstein , Watanabe , Brown . Cellular pathology of progressive atherosclerosis in the WHHL rabbit. An animal model of familial hypercholesterolemia. Arteriosclerosis. 1983;3:87–101
  12. Shiomi , Ito , Shiraishi , Watanabe . Inheritability of atherosclerosis and the role of lipoproteins as risk factors in the development of atherosclerosis in WHHL rabbits: risk factors related to coronary atherosclerosis are different from those related to aortic atherosclerosis. Atherosclerosis. 1992;96:43–52
  13. Ishii , Kita , Yokode , Kume , Nagano , Otani , et al. Characterization of very low density lipoprotein from Watanabe heritable hyperlipidemic rabbits. J. Lipid Res. 1989;30:1–7
  14. Ito , Yamada , Shiomi . Progression of coronary atherosclerosis relates to the onset of myocardial infarction in an animal model of spontaneous myocardial infarction (WHHLMI rabbits). Exp. Anim. 2004;53:339–346
  15. Greenspan , Fowler . Spectrofluorometric studies of the lipid probe, nile red. J. Lipid Res. 1985;26:781–789
  16. Kushiyama , Shojima , Ogihara , Inukai , Sakoda , Fujishiro , et al. Resistin-like molecule beta activates MAPKs, suppresses insulin signaling in hepatocytes, and induces diabetes, hyperlipidemia, and fatty liver in transgenic mice on a high fat diet. J. Biol. Chem. 2005;280:42016–42025
  17. Fukuda . Classification and treatment of diabetic retinopathy. Diabetes Res. Clin. Pract. 1994;24 Suppl.:S171–176
  18. Veglio , Paglieri , Rabbia , Bisbocci , Bergui , Cerrato . Hypertension and cerebrovascular damage. Atherosclerosis. 2008;
  19. Silva , Pinto , Biswas , de Faria , de Faria . Hypertension increases retinal inflammation in experimental diabetes: a possible mechanism for aggravation of diabetic retinopathy by hypertension. Curr. Eye Res. 2007;32:533–541
  20. Avogaro , de Kreutzenberg , Fadini . Endothelial dysfunction: causes and consequences in patients with diabetes mellitus. Diabetes Res. Clin. Pract. 2008;82 Suppl. 2:S94–S101
  21. Vaidyula , Boden , Rao . Platelet and monocyte activation by hyperglycemia and hyperinsulinemia in healthy subjects. Platelets. 2006;17:577–585
  22. Sugimoto , Baba , Suda , Yasujima , Yagihashi . Peripheral neuropathy and microangiopathy in rats with insulinoma: association with chronic hyperinsulinemia. Diabetes Metab. Res. Rev. 2003;19:392–400
  23. Yang , Shi , Hao , Li , Le . Increasing oxidative stress with progressive hyperlipidemia in human: relation between malondialdehyde and atherogenic index. J. Clin. Biochem. Nutr. 2008;43:154–158
  24. Ogihara , Asano , Katagiri , Sakoda , Anai , Shojima , et al. Oxidative stress induces insulin resistance by activating the nuclear factor-kappa B pathway and disrupting normal subcellular distribution of phosphatidylinositol 3-kinase. Diabetologia. 2004;47:794–805
  25. Osto , Matter , Kouroedov , Malinski , Bachschmid , Camici , et al. c-Jun N-terminal kinase 2 deficiency protects against hypercholesterolemia-induced endothelial dysfunction and oxidative stress. Circulation. 2008;118:2073–2080
  26. Kakehashi , Inoda , Mameuda , Kuroki , Jono , Nagai , et al. Relationship among VEGF, VEGF receptor, AGEs, and macrophages in proliferative diabetic retinopathy. Diabetes Res. Clin. Pract. 2008;79:438–445
  27. Yoshino , Hirano , Nagata , Maeda , Naka , Murata , et al. Hypertriglyceridemia in nephrotic rats is due to a clearance defect of plasma triglyceride: overproduction of triglyceride-rich lipoprotein is not an obligatory factor. J. Lipid Res. 1993;34:875–884
  28. Wong , Molyneaux , Constantino , Twigg , Yue . Timing is everything: age of onset influences long-term retinopathy risk in type 2 diabetes, independent of traditional risk factors. Diabetes Care. 2008;31:1985–1990
  29. Chiasson , Josse , Gomis , Hanefeld , Karasik , Laakso . Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial. Lancet. 2002;359:2072–2077
  30. PROactive study. Lancet. 2006;367:982

PII: S0168-8227(09)00459-8

doi: 10.1016/j.diabres.2009.10.011

Diabetes Research and Clinical Practice
Volume 87, Issue 1 , Pages 57-63 , January 2010