Serum N-terminal-pro-brain natriuretic peptide (NT-pro-BNP) and homocysteine levels in type 2 diabetic patients with asymptomatic left ventricular diastolic dysfunction

Görmüş, U.; Özmen, D.; Özmen, B.; Parıldar, Z.; Özdoğan, Ö.; Mutaf, I.; Bayındır, O.

doi:10.1016/j.diabres.2009.10.010

« Previous Next »Diabetes Research and Clinical Practice
Volume 87, Issue 1 , Pages 51-56, January 2010

Serum N-terminal-pro-brain natriuretic peptide (NT-pro-BNP) and homocysteine levels in type 2 diabetic patients with asymptomatic left ventricular diastolic dysfunction

U. Görmüş
- Department of Molecular Medicine, Institute of Experimental Medical Research, İstanbul University, İstanbul, Turkey
D. Özmen
- Department of Clinical Biochemistry, Ege University School of Medicine, İzmir 35100, Turkey
- Corresponding author. Tel.: +90 232 3903378; fax: +90 232 3392144.
B. Özmen
- Department of Endocrinology, Celal Bayar University School of Medicine, Manisa 45100, Turkey
Z. Parıldar
- Department of Clinical Biochemistry, Ege University School of Medicine, İzmir 35100, Turkey
Ö. Özdoğan
- Department of Cardiology, Ege University School of Medicine, İzmir 35100, Turkey
I. Mutaf
- Department of Clinical Biochemistry, Ege University School of Medicine, İzmir 35100, Turkey
O. Bayındır
- Department of Clinical Biochemistry, Ege University School of Medicine, İzmir 35100, Turkey

Received 25 May 2009; received in revised form 6 October 2009; accepted 19 October 2009. published online 23 November 2009.

Abstract

Aims

: The aim of this study was to determine serum NT-proBNP and plasma Hcy levels and to explore the relationship between serum NT-proBNP and plasma Hcy levels in type 2 diabetic patients with and without asymptomatic LVDD.

Methods

: NT-proBNP and Hcy levels were measured 31 patients with type 2 diabetes mellitus. According to echocardiographic data, diabetic patients were divided into two groups: normal LV function or LV diastolic dysfunction.

Results

: Serum NT-proBNP levels in diabetic patients with LVDD were significantly higher than in diabetic patients with normal LV function and controls. The area under the receiver-operating characteristic (ROC) curve for NT-proBNP to separate normal vs. diastolic dysfunction was 0.96 in type 2 diabetic patients. Plasma Hcy levels were significantly higher in both diabetic groups than in controls. Positive correlation was noted between NT-proBNP and Hcy levels in diabetic patients with LVDD (r=0.881, p=0.0001).

Conclusions

: The correlation between elevated NT-proBNP and Hcy levels in diabetic patients with LVDD suggest an association between homocysteinemia and increased NT-proBNP secretion. Our data indicate that NT-proBNP may be a simple screening tool to select diabetic patients with LVDD requiring further examination with echocardiography.

Keywords: Left ventricular diastolic dysfunction, Type 2 diabetes mellitus, NT-proBNP, Homocysteine