Diabetes Research and Clinical Practice
Volume 87, Issue 1 , Pages 38-43 , January 2010

Spirulina protects against Rosiglitazone induced osteoporosis in insulin resistance rats

  • Sumeet Gupta

      Affiliations

    • Department of Pharmacology, M. M. College of Pharmacy, M. M. University, Mullana, Ambala, Haryana, India
    • ,
  • H.J. Hrishikeshvan

      Affiliations

    • Department of Pharmacology, Krupanidhi College of Pharmacy, Kormangala, Bangalore, India
    • ,
  • Prabodh K. Sehajpal

      Affiliations

    • Department of Molecular Biology and Biochemistry, Guru Nanak Dev University, Amritsar-143005, Punjab, India
    • Corresponding Author InformationCorresponding author. Tel.: +91 9216218220; fax: +91 183 2258820.

Received 8 June 2009 ,Revised 30 September 2009 ,Accepted 5 October 2009.

References 

  1. Joshi N., Mahajan M., Infection and diabetes. In: Pickup J.C., Williams G. (Eds.), Textbook of Diabetes, 3rd ed., Malden Massachusetts Blackwell Science 2003, vol. 2, pp. 1–16 (Chapter 40).
  2. Keen H, Tang NG, Tang Fui S. The definition and classification of diabetes mellitus. J. Clin. Endocrinol. Metab. 1982;11:279–305
  3. Ziv E, Shafrir E, Kalman R, Galer S, Baron H. Changing patterns of prevalence of insulin resistance in Psammomys obesus, a model of nutritionally induced type 2 diabetes. Metabolism. 1999;48:1549–1554
  4. Cheng D. Prevalance, predisposition and prevention of Type-II diabetes. Nutr. Metab. 2005;18:2–29
  5. Ramarao P, Kaul CL. Insulin resistance: current therapeutic approaches. Drugs Today. 1999;35:895–911
  6. Bailey CJ. Drugs on the horizon for diabesity. Curr. Diabetes Rep. 2005;5:353–359
  7. Letimann JM, Moore CB, Smith-Oliver TA, Wilkinson WO, Wilson TM. An anti diabetic thiazolidinedione is a highly affinity ligand for peroxisome proliferators activated receptor gamma (PPAR-gamma). J. Biol. Chem. 1995;270:12953–12956
  8. Lee CH, Olson P, Evans RM. Mini review lipid metabolism, metabolic diseases, peroxisome proliferators-activated receptor. Endocrinology. 2003;144:2201
  9. Rosen ED, Spiegelman BM. PPAR gamma a nuclear regular of metabolism differentiation and cell growth. J. Biol. Chem. 2001;276:37731–37734
  10. Ren D, Collingwood TN, Rebor EJ, Wolffe AP, Camp HS. PPAR gamma knock down by engineered transcription factors: exogenous PPAR gamma 2 but not PPAR gamma reactivates adipogenesis. Genes Nev. 2002;16:27–32
  11. Jiang Y, Johagirdor B, Rein Hard RL. Pluripotency of mesenchymal cells derived from adult marrow. Nature. 2002;418:41–49
  12. Bianco P, Riminucci M, Gronthoss , Robey PG. Bone marrow stromal stem cells: nature, biology and potential applications. Stem Cells. 2001;19:180–192
  13. Schwartz AV, SellMeyer DE, Vittingoff E, Palermo L, Lecka-Czernik B, Feingald KR, et al. Thiazolidinedione (TZD) use & bone density in older adults with diabetes. J. Clin. Endocrinol. Metab. 2006;91(9):3276–3278
  14. Lecka-Czemik B, Gubrij I, Moerman EA. Inhibition of OSF2/Cb F A/expression terminal osteoblast differentiation by PPAR-gamma2. J. Cell. Biochem. 1999;74:357–371
  15. Bnouham M, Ziyyat A, Mekhfi H, Tahri A, Legssyer A. Medicinal plants with potential antidiabetic activity-a review of ten years of herbal medicine research (1990–2000). Int. J. Diabetes Metab. 2006;14:1–25
  16. Modak M, Dixit P, Londhe J, Ghaskadbi S, Devasagayam TPA. Indian herbs and herbal drugs used for the treatment of diabetes. J. Clin. Biochem. Nutr. 2007;40:163–173
  17. Hayashi K, Hayashi T, Kojima I. A natural sulfated polysaccharide, calcium spirulina isolated from Spirulina plantensis: in vitro and ex vivo evaluation of anti-herpes simplex virus and anti-human immuno-deficiency virus activities. AIDS Res. Hum. Retroviruses. 1996;12:1463–1471
  18. Mittal A, Suresh-Kumar PV, Banerjee S, Rao AR, Kumar A. Modulatory potential of Spirulina fusiformis on carcinogenic metabolizing enzymes in swiss albino mice. Phytother. Res. 1999;13:111–114
  19. Qureshi MA, Garlich JD, Kidd MT. Dietary Spirulina plantesis enhances humoral and cell mediated immune functions in chickens. Immunopharmacol. Immunotoxicol. 1996;18:465–476
  20. Simsek N, Karadeniz A, Kalkan Y, Keles ON, Unal B. Spirulina platensis feeding inhibited the anemia- and leucopenia-induced lead and cadmium in rats. J. Hazard. Mater. 2009;164:1304–1309
  21. Verma S, Samarth R, Panwar M. Evaluation of radioprotective effects of Spirulina in swiss albino mice. Asian. J. Exp. Sci. 2000;20:121–126
  22. Saxena PS, Kumar M. Modulatory potential of Spirulina fusiformis on testicular phosphatases in Swiss albino mice against mercury intoxication. Indian J. Exp. Biol. 2004;42:998–1002
  23. Shalam MD, Harish MS, Farhana SA. Prevention of dexamethasone and fructose induced insulin resistance in rats by SH-01D a herbal preparation. Ind. J. Pharmacol. 2006;38:419–422
  24. Giordano BP, Thrash W, Hollenbaugh L, Dube WP, Hodges C, Swain A, et al. Performance of seven blood glucose testing systems at high altitude. Diabetes Educ. 1989;15:444–448
  25. Kaur G, Kulkarni S. Anti obesity effect of a polyherbal formulation, OB-200G in female rats fed on cafeteria and atherogenic diets. Ind. J. Pharmacol. 2000;32:294–299
  26. Allain CC, Poon LS, Chan CS, Richmond W, Fu PC. Enzymatic determination of total serum cholesterol. Clin. Chem. 1974;20:470–475
  27. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem. 1972;18:499–502
  28. Prashantha KBR, Praveen TK, Nanjan MJ, Karvekar MD, Suresh B. Serum glucose and triglycerides lowering activity of some novel glitazones against dexamethasone-induced hyperlipidemia and insulin resistance. Ind. J. Pharmacol. 2007;39:299–302
  29. Wy SO, Mcy Ng, Lee SC, Sanke T, Lee HK, Chan JCN. Genetics of type2 diabetes mellitus. Hong Kong Med. J. 2000;6:69–76
  30. Turnbow MA, Keller SR, Rice M, Garner CW. Dexamethasone down-regulation of insulin receptor substrate-1 in 3T3-L-1 adipocytes. J. Biol. Chem. 1994;269(4):2516–2520
  31. Tenpe CR, Yeole PG. Comparative evaluation of antidiabetic activity of some marketed polyherbal formulations in alloxan induced diabetic rats. Int. J. Pharm. Tech. Res. 2009;1:43–49
  32. Ishimi Y, Surgayama F, Ezaki J, Fujioka M, Wu J. Effects of Spirulina, blue-green alga, on bone metabolism in ovariectomized rats and hind limb-unloaded mice. Biosci. Biotechnol. Biochem. 2006;70(2):363–368
  33. Anitha L, Chandra Lekha KR. Antidiabetic property of spirulina. Diabetol. Croatica. 2006;35(2):29–33
  34. Vincet JB. The biochemistry of chromium. J. Nutr. 2000;715–718
  35. Panam P, Uliyar M, Uma Iyer. Role of spirulina in the control of glycemia and lipidemia in type 2 diabetes mellitus. J. Med. Food. 2001;4:193–199
  36. Zhu Y, Qi C, Korenberg JR, Chen XN, Noya D, Rao MS, et al. Structural organization of mouse peroxisome proliferator-activated receptor gamma (m PPAR gamma) gene: alternative promoter use and different splicing yield two m PPAR gamma isoforms. Proc. Natl. Acad. Sci. U.S.A. 1995;92(17):7921–7925
  37. Rzonca SO, Suva LJ, Gaddy D, Montague DC, Lecka-Czernik B. Bone is the target for the antidiabetic compound rosiglitazone. Endocrinology. 2004;145:401–406

PII: S0168-8227(09)00423-9

doi: 10.1016/j.diabres.2009.10.002

Diabetes Research and Clinical Practice
Volume 87, Issue 1 , Pages 38-43 , January 2010

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