Diabetes Research and Clinical Practice
Volume 87, Issue 1 , Pages 38-43, January 2010

Spirulina protects against Rosiglitazone induced osteoporosis in insulin resistance rats

  • Sumeet Gupta

      Affiliations

    • Department of Pharmacology, M. M. College of Pharmacy, M. M. University, Mullana, Ambala, Haryana, India
    • ,
  • H.J. Hrishikeshvan

      Affiliations

    • Department of Pharmacology, Krupanidhi College of Pharmacy, Kormangala, Bangalore, India
    • ,
  • Prabodh K. Sehajpal

      Affiliations

    • Department of Molecular Biology and Biochemistry, Guru Nanak Dev University, Amritsar-143005, Punjab, India
    • Corresponding Author InformationCorresponding author. Tel.: +91 9216218220; fax: +91 183 2258820.

Received 8 June 2009; received in revised form 30 September 2009; accepted 5 October 2009. published online 06 November 2009.

Abstract 

Aim

The study was undertaken to assess the protective effect of Spirulina fusiformis extract against Rosiglitazone induced osteoporosis and pharmacodynamic effects of Rosiglitazone with Spirulina in treating hyperglycemia and hyperlipidemia of insulin resistance rat.

Method

For this aim, 30 Wistar albino rats were equally divided into five groups as control (C), diabetes mellitus (DM), diabetes mellitus+Rosiglitazone (DM+R), diabetes mellitus+Spirulina (DM+S), and diabetes mellitus+Rosiglitazone+Spirulina (DM+R+S). Serum glucose, triglyceride, HDL, LDL and insulin concentrations were estimated by routine standard methods in blood samples collected on 21th day. Integrity of the bone surface was examined by scanning electronic microscopy, and bone strength was measured by micro-hardness test on 45th day.

Results

A significant decrease in total bone mineral density was observed in group DM+R rats (p<0.05). The number and depth of resorptive pits on surface of the bone in Rosiglitazone treated rats improved clearly with Spirulina administration. The intactness and integrity of the bone surface as well as the bone strength improved due to the high content of calcium and phosphorous in Spirulina. Besides, chromium and gamma-linoleic acid in Spirulina helped to decrease the fasting serum glucose, HDL, LDL and triglycerides levels in insulin resistance rats.

Conclusion

These findings suggest that combination therapy of Rosiglitazone with Spirulina reduced the risk of osteoporosis in insulin resistance rats. Additionally, Spirulina complemented the antihyperglycemic and antilipidemic activity of Rosiglitazone.

Keywords: Rosiglitazone, Spirulina, Insulin resistance, Diabetes mellitus, Osteoporosis, Rat

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S0168-8227(09)00423-9

doi:10.1016/j.diabres.2009.10.002

Diabetes Research and Clinical Practice
Volume 87, Issue 1 , Pages 38-43, January 2010

Article Tools

* Image Usage & Resolution