Diabetes Research and Clinical Practice
Volume 87, Issue 1 , Pages e1-e3 , January 2010

Effects of resistance training combined with antioxidant supplementation on fat-free mass and insulin sensitivity in healthy elderly subjects

  • Florian Bobeuf

      Affiliations

    • Research Centre on Aging, University of Sherbrooke, Sherbrooke, QC, Canada
    • Department of Medicine, Service of Geriatrics, Faculty of Medicine, University of Sherbrooke, Sherbrooke, QC, Canada
    • ,
  • Mélissa Labonté

      Affiliations

    • Research Centre on Aging, University of Sherbrooke, Sherbrooke, QC, Canada
    • Faculty of Physical Education and Sport, University of Sherbrooke, Sherbrooke, QC, Canada
    • ,
  • Abdelouahed Khalil

      Affiliations

    • Research Centre on Aging, University of Sherbrooke, Sherbrooke, QC, Canada
    • Department of Medicine, Service of Geriatrics, Faculty of Medicine, University of Sherbrooke, Sherbrooke, QC, Canada
    • ,
  • Isabelle J. Dionne

      Affiliations

    • Research Centre on Aging, University of Sherbrooke, Sherbrooke, QC, Canada
    • Faculty of Physical Education and Sport, University of Sherbrooke, Sherbrooke, QC, Canada
    • Corresponding Author InformationCorresponding author. Research Centre on Aging, 1036, rue Belvédère Sud, Sherbrooke, QC, Canada, J1H 4C4. Tel.: +1 819 780 2220×45671; fax: +1 819 829 7141.

Received 30 March 2009 ,Revised 22 September 2009 ,Accepted 5 October 2009.

References 

  1. Moore DR, Del Bel NC, Nizi KI, Hartman JW, Tang JE, Armstrong D, et al. Resistance training reduces fasted- and fed-state leucine turnover and increases dietary nitrogen retention in previously untrained young men. J. Nutr. 2007;137:985–991
  2. Wright D, Sutherland L. Antioxidant supplemention in the treatment of skeletal muscle insulin resistance: potential mechanisms and clinical relevance. Appl. Physiol. Nutr. Metab. 2008;33:21–31
  3. Dionne IJ, Melancon MO, Brochu M, Ades PA, Poelhman ET. Age-related differences in metabolic adaptations following resistance training in women. Exp. Gerontol. 2004;39:133–138
  4. Toth MJ, Beckett T, Poehlman ET. Physical activity and the progressive change in body composition with aging: current evidence and research issues. Med. Sci. Sports Exerc. 1999;31:S590–S596
  5. Rudich A, Kozlovsky N, Potashnik R, Bashan N. Oxidant stress reduces insulin responsiveness in 3T3-L1 adipocytes. Am. J. Physiol. 1997;272:E935–E940
  6. Paolisso G, D’Amore A, Di Maro G, Galzerano D, Tesauro P, Varricchio M, et al. Evidence for a relationship between free radicals and insulin action in the elderly. Metabolism. 1993;42:659–663
  7. Paolisso G, D’Amore A, Balbi V, Volpe C, Galzerano D, Giugliano D, et al. Plasma vitamin C affects glucose homeostasis in healthy subjects and in non-insulin-dependent diabetics. Am. J. Physiol. 1994;266:E261–E268
  8. Dela F, Kjaer M. Resistance training, insulin sensitivity and muscle function in the elderly. Essays Biochem. 2006;42:75–88
  9. Pereira LO, Lancha AH. Effect of insulin and contraction up on glucose transport in skeletal muscle. Prog. Biophys. Mol. Biol. 2004;84:1–27
  10. Ceriello A. Oxidative stress and glycemic regulation. Metabolism. 2000;49:27–29
  11. Paolisso G, D’Amore A, Giugliano D, Ceriello A, Varricchio M, D’Onofrio F. Pharmacologic doses of vitamin E improve insulin action in healthy subjects and non-insulin-dependent diabetic patients. Am. J. Clin. Nutr. 1993;57:650–656
  12. Karakelides H, Nair KS. Sarcopenia of aging and its metabolic impact. Curr. Top. Dev. Biol. 2005;68:123–148
  13. Goldfarb AH, McKenzie MJ, Bloomer RJ. Gender comparisons of exercise-induced oxidative stress: influence of antioxidant supplementation. Appl. Physiol. Nutr. Metab. 2007;32:1124–1131
  14. Labonté M, Bobeuf F, Bouchard DR, Sénéchal M, Tessier D, Khalil A, et al. Effects of antioxidant supplements combined with resistance exercise on gains in fat-free mass in healthy elderly subjects: a pilot study. J. Am. Geriatr. Soc. 2008;56:1766–1768
  15. Ji LL. Exercise at old age: does it increase or alleviate oxidative stress?. Ann. N. Y. Acad. Sci. 2001;928:236–247

PII: S0168-8227(09)00422-7

doi: 10.1016/j.diabres.2009.10.001

Diabetes Research and Clinical Practice
Volume 87, Issue 1 , Pages e1-e3 , January 2010

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