Nephropathic complication of type-2 diabetes is following pattern of autoimmune diseases?

Arababadi, Mohammad Kazemi; Nosratabadi, Reza; Hassanshahi, Gholamhossein; Yaghini, Narges; Pooladvand, Vahid; Shamsizadeh, Ali; Hakimi, Hamid; Derakhshan, Reza

doi:10.1016/j.diabres.2009.09.027

« Previous Next »Diabetes Research and Clinical Practice
Volume 87, Issue 1 , Pages 33-37, January 2010

Nephropathic complication of type-2 diabetes is following pattern of autoimmune diseases?

Mohammad Kazemi Arababadi
- Dept. of Microbiology, Hematology and Immunology, Faculty of Medicine, Rafsanjan University of Medical Science, Rafsanjan, Iran
- Corresponding author at: Dept. of Microbiology and Immunology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Tel.: +98 3915234003–5; fax: +98 3915225209.
Reza Nosratabadi
- Dept. of Laboratory Sciences, Faculty of Medicine, Islamic Azad University, Zahedan Branch, Zahedan, Iran
Gholamhossein Hassanshahi
- Dept. of Microbiology, Hematology and Immunology, Faculty of Medicine, Rafsanjan University of Medical Science, Rafsanjan, Iran
Narges Yaghini
- Dept. of Biochemistry, Faculty of Medicine, Rafsanjan University of Medical Science, Rafsanjan, Iran
Vahid Pooladvand
- Dept. of Biochemistry, Faculty of Medicine, Rafsanjan University of Medical Science, Rafsanjan, Iran
Ali Shamsizadeh
- Dept. of Physiology, Faculty of Medicine, Rafsanjan University of Medical Science, Rafsanjan, Iran
Hamid Hakimi
- Dept. of Microbiology, Hematology and Immunology, Faculty of Medicine, Rafsanjan University of Medical Science, Rafsanjan, Iran
Reza Derakhshan
- Ali-Ebne Abitaleb Hospital, Rafsanjan University of Medical Science, Rafsanjan, Iran

Received 2 May 2009; received in revised form 23 September 2009; accepted 28 September 2009. published online 30 October 2009.

Abstract

The impact of several environmental and genetic factors on diabetes and its complications is well documented. The present study was aimed to examine the serum levels of IL-17A and IFN-γ as antagonistic cytokines in nephropathic and non-nephropathic type-2 diabetic patients. In this experimental study, serum samples were obtained from 180 type-2 diabetic patients, 100 nephropathic type-2 diabetic patients and 100 healthy controls. Serum levels of IL-17A and IFN-γ was detected by ELISA. Results of this study showed that the serum level of IFN-γ was higher in both diabetic patients (nephropathic and non-nephropathic) in comparison to the controls. In terms of IL-17A, while non-nephropathic type-2 diabetic patients showed an increased serum level of it, the other patients group had a lower serum level. Based on these findings, it can be concluded that the lower serum level of IL-17A is possibly associated with nephropathic complications of type-2 diabetes.

Keywords: IFN-γ, IL-17A, Diabetes, Nephropathy