Diabetes Research and Clinical Practice
Volume 87, Issue 2 , Pages 224-227 , February 2010

Neuropsychological status of elderly patients with diabetes mellitus

  • Hiroyuki Shimada

      Affiliations

    • Department of Geriatrics and Neurology, Osaka City University Medical School, Osaka 545-8585, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 6 6645 3889; fax: +81 6 6646 5599.
    • ,
  • Takami Miki

      Affiliations

    • Department of Geriatrics and Neurology, Osaka City University Medical School, Osaka 545-8585, Japan
    • ,
  • Akiko Tamura

      Affiliations

    • Department of Geriatrics and Neurology, Osaka City University Medical School, Osaka 545-8585, Japan
    • ,
  • Suzuka Ataka

      Affiliations

    • Department of Geriatrics and Neurology, Osaka City University Medical School, Osaka 545-8585, Japan
    • ,
  • Masanori Emoto

      Affiliations

    • Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Medical School, Osaka, Japan
    • ,
  • Yoshiki Nishizawa

      Affiliations

    • Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Medical School, Osaka, Japan

Received 28 April 2009 ,Revised 21 September 2009 ,Accepted 28 September 2009.

References 

  1. Biessels GJ, Staekenborg S, Brunner E, Brayne C, Scheltens P. Risk of dementia in diabetes mellitus: a systematic review. Lancet Neurol. 2006;5:64–74
  2. Selkoe DJ. The origin of Alzheimer disease: a is for amyloid. JAMA. 2000;283:1615–1617
  3. Farris W, Mansourian S, Chang Y, Lindsley L, Eckman EA, Frosch MP, et al. Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. Proc. Natl. Acad. Sci. USA. 2003;100:4162–4167
  4. Qiu WQ, Folstein MF. Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: review and hypothesis. Neurobiol. Aging. 2006;27:190–198
  5. Arvanitakis Z, Wilson RS, Bennett DA. Diabetes mellitus, dementia, and cognitive function in older persons. J. Nutr. Health Aging. 2006;10:287–291
  6. Murthy SB, Jawaid A, Schulz PE. Diabetes mellitus and dementia: advocating an annual cognitive screening in patients with diabetes mellitus. J. Am. Geriatr. Soc. 2008;56:1976–1977
  7. Ott A, Stolk RP, van Harskamp F, Pols HA, Hofman A, Breteler M. Diabetes mellitus and the risk of dementia: the Rotterdam Study. Neurology. 1999;53:1937–1942
  8. Peila R, Rodriguez BL, Launer LJ. Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: the Honolulu-Asia Aging Study. Diabetes. 2002;51:1256–1262
  9. Xu WL, Qiu CX, Wahlin A, Winblad B, Fratiglioni L. Diabetes mellitus and risk of dementia in the Kungsholmen project: a 6-year follow-up study. Neurology. 2004;63:1181–1186
  10. Pasquier F, Pasquier F, Boulogne A, Leys D, Fontaine P. Diabetes mellitus and dementia. Diabetes Metab. 2006;32:403–414
  11. Akomolafe A, Beiser A, Meigs JB, Au R, Green RC, Farrer LA, et al. Diabetes mellitus and risk of developing Alzheimer disease: results from the Framingham Study. Arch. Neurol. 2006;63:1551–1555
  12. Petersen RC. Mild cognitive impairment: current research and clinical implications. Semin. Neurol. 2007;27:22–31
  13. Luchsinger JA, Reitz C, Patel B, Tang MX, Manly JJ, Mayeux R. Relation of diabetes to mild cognitive impairment. Arch. Neurol. 2007;64:570–575
  14. Roberts RO, Roberts RO, Geda YE, Knopman DS, Christianson TJ, Pankratz VS, et al. Association of duration and severity of diabetes mellitus with mild cognitive impairment. Arch. Neurol. 2008;65:1066–1073
  15. Clinical Practice Recommendations . Diabetes Care. 2005;28(Suppl. 1):S1–79
  16. Wilson B, Cockburn J, Baddeley A, Hiorns R. The development and validation of a test battery for detecting and monitoring everyday memory problems. J. Clin. Exp. Neuropsychol. 1989;11:855–870
  17. Wilson B, Cockburn J, Baddeley A. The Rivermead Behavioral Memory Test. England: Thames Valley Test Company; 1991;
  18. Kazui H, Matsuda A, Hirono N, Mori E, Miyoshi N, Ogino A, et al. Everyday memory impairment of patients with mild cognitive impairment. Dement. Geriatr. Cogn. Disord. 2005;19:331–337
  19. Strachan MW, Str Deary IJ, Ewing FM, Frier BM. Is type II diabetes associated with an increased risk of cognitive dysfunction? A critical review of published studies. Diabetes Care. 1997;20:438–445
  20. van den Berg E, Kessels RP, de Haan EH, Kappelle LJ, Biessels GJ. Mild impairments in cognition in patients with type 2 diabetes mellitus: the use of the concepts MCI and CIND. J. Neurol. Neurosurg. Psychiatry. 2005;76:1466–1467
  21. Vanhanen M, Koivisto K, Kuusisto J, Mykkanen L, Helkala EL, Hanninen T, et al. Cognitive function in an elderly population with persistent impaired glucose tolerance. Diabetes Care. 1998;21:398–402

PII: S0168-8227(09)00418-5

doi: 10.1016/j.diabres.2009.09.026

Diabetes Research and Clinical Practice
Volume 87, Issue 2 , Pages 224-227 , February 2010

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