Diabetes Research and Clinical Practice
Volume 86, Issue 3 , Pages 173-176 , December 2009

Role of asymmetric-dimethyl-l-arginine (ADMA) and nitrite/nitrate (NOx) in the pathogenesis of oxidative stress in female subjects with uncomplicated type 1 diabetes mellitus

  • Dario Pitocco

      Affiliations

    • Diabetologia, Catholic University, Rome, Italy
    • These authors equally contributed to this article.
    • Corresponding Author InformationCorresponding author at: Servizio di Diabetologia, Pol. Universitario “A. Gemelli”, L.go A. Gemelli, 00168 Roma, Italy. Tel.: +39 06 30154071; fax: +39 06 3050052.
    • ,
  • Francesco Zaccardi

      Affiliations

    • Diabetologia, Catholic University, Rome, Italy
    • These authors equally contributed to this article.
    • ,
  • Enrico Di Stasio

      Affiliations

    • Department of Biochemistry, Catholic University, Rome, Italy
    • ,
  • Federica Romitelli

      Affiliations

    • Department of Biochemistry, Catholic University, Rome, Italy
    • ,
  • Francesca Martini

      Affiliations

    • Diabetologia, Catholic University, Rome, Italy
    • ,
  • Giovanni Luca Scaglione

      Affiliations

    • Department of Biochemistry, Catholic University, Rome, Italy
    • ,
  • Dorina Speranza

      Affiliations

    • Department of Biochemistry, Catholic University, Rome, Italy
    • ,
  • Stefano Santini

      Affiliations

    • Laboratorio Analisi Cliniche e Microbiologiche, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), Italy
    • ,
  • Cecilia Zuppi

      Affiliations

    • Department of Biochemistry, Catholic University, Rome, Italy
    • ,
  • Giovanni Ghirlanda

      Affiliations

    • Diabetologia, Catholic University, Rome, Italy

Received 19 June 2009 ,Revised 7 September 2009 ,Accepted 17 September 2009.

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  8. Böger RH. The emerging role of asymmetric dimethylarginine as a novel cardiovascular risk factor. Cardiovasc. Res. 2003;59(October (4)):824–833(Review)
  9. Nijveldt RJ, Siroen MP, Teerlink T, van Leeuwen PA. Elimination of asymmetric dimethylarginine by the kidney and the liver: a link to the development of multiple organ failure?. J. Nutr. 2004;134(October (10 Suppl.)):2848S–2852S(discussion 2853S. Review)
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  12. Stephenson J, Fuller JH for the EURODIAB Complications Study Group. Microvascular and acute complications in IDDM patients: the EURODIAB IDDM complications study. Diabetologia. 1994;37:278–285
  13. Romitelli F, Santini SA, Chierici E, Pitocco D, Tavazzi B, Amorini AM, et al. Comparison of nitrite/nitrate concentration in human plasma and serum samples measured by the enzymatic batch Griess assay, ionpairing HPLC and ion-trap GC–MS: the importance of a correct removal of proteins in the Griess assay. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 2007;851:257–267
  14. Schulze F, Wesemann R, Schwedhelm E, Sydow K, Albsmeier J, Cooke JP, et al. Determination of asymmetric dimethylarginine (ADMA) using a novel ELISA assay. Clin. Chem. Lab. Med. 2004;42(12):1377–1383
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  16. Vareniuk I, Pavlov IA, Obrosova IG. Inducible nitric oxide synthase gene deficiency counteracts multiple manifestations of peripheral neuropathy in a streptozotocin-induced mouse model of diabetes. Diabetologia. 2008;51(November (11)):2126–2133(Epub 2008 September 19)
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  18. Sydow K, Münzel T. ADMA and oxidative stress. Atheroscler. Suppl. 2003;4(December (4)):41–51(Review)
  19. Heilman K, Zilmer M, Zilmer K, Kool P, Tillmann V. Elevated plasma adiponectin and decreased plasma homocysteine and asymmetric dimethylarginine in children with type 1 diabetes. Scand. J. Clin. Lab. Invest. 2009;69(1):85–91
  20. Abhary S, Kasmeridis N, Burdon KP, Kuot A, Whiting MJ, Yu WP, et al. Diabetic retinopathy is associated with elevated serum asymmetric and symmetric dimethylarginines. Diabetes Care. 2009;August 12 [Epub ahead of print]
  21. Cighetti G, Fermo I, Aman CS, Ferraroni M, Secchi A, Fiorina P, et al. Dimethylarginines in complicated type 1 diabetes: roles of insulin, glucose, and oxidative stress. Free Radic. Biol. Med. 2009;47(August (3)):307–311

PII: S0168-8227(09)00411-2

doi: 10.1016/j.diabres.2009.09.019

Diabetes Research and Clinical Practice
Volume 86, Issue 3 , Pages 173-176 , December 2009

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