Diabetes Research and Clinical Practice
Volume 86, Issue 3 , Pages e46-e49 , December 2009

Effect of treatment with losartan on salt sensitivity and SGLT2 expression in hypertensive diabetic rats

  • Horacio Osorio

      Affiliations

    • Department of Molecular Biomedicine, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV) México City, C.P. 07360, Mexico
    • ,
  • Rocío Bautista

      Affiliations

    • Department of Nephrology Instituto Nacional de Cardiología “Ignacio Chavez” México City, Mexico
    • ,
  • Amelia Rios

      Affiliations

    • CINVESTAV Monterrey, Nuevo León México, Mexico
    • ,
  • Martha Franco

      Affiliations

    • Department of Nephrology Instituto Nacional de Cardiología “Ignacio Chavez” México City, Mexico
    • ,
  • José Santamaría

      Affiliations

    • Department of Nephrology Instituto Nacional de Cardiología “Ignacio Chavez” México City, Mexico
    • ,
  • Bruno Escalante

      Affiliations

    • Department of Molecular Biomedicine, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV) México City, C.P. 07360, Mexico
    • CINVESTAV Monterrey, Nuevo León México, Mexico
    • Corresponding Author InformationCorresponding author at: CINVESTAV Monterrey, Vía del Conocimiento 201 Parque Investigación e Innovación Tecnológica, Apodaca NL CP 66600, Mexico. Tel.: +52 81 1156 1740.

Received 19 February 2009 ,Revised 24 August 2009 ,Accepted 7 September 2009.

References 

  1. Noergaard K, Feldt-Rasmussen B, Borch-Johnsen K, Saelan H, Deckert T. Prevalence of hypertension in type-1 (insulin-dependent) diabetes mellitus. Diabetologia. 1990;33:407–410
  2. Tuck ML, Corry D, Trujillo A. Salt sensitive blood pressure and exaggerated vascular reactivity in the hypertension of diabetes mellitus. Am. J. Med. 1990;88:210–216
  3. Bautista R, Manning R, Martínez F, del C Avila-Casado M, Soto V, Medina A, et al. Angiotensin II-dependent increased expression of Na+-glucose cotransporter in hypertension. Am. J. Physiol. Renal. Physiol. 2004;286:F127–F133
  4. Tabatabaia N, Sharma M, Blumenthal S, Petering D. Enhanced expressions of sodium glucose cotransporters in the kidney of diabetic Zucker rats. Diabetes Res. Clin. Pract. 2009;83(1):e27–e30
  5. Vestri S, Okamoto MM, de Freitas HS, Aparecida Dos Santos R, Nunes MT, Morimatsu M, et al. Changes in sodium or glucose filtration rate modulate expression of glucose transporters in renal proximal tubular cells of rats. J. Membr. Biol. 2001;182:105–112
  6. de Cavanagh EMV, Inserra F, Toblli J, Stella I, Fraga GC, Ferder L. Enalapril attenuates oxidative stress in diabetic rats. Hypertension. 2001;38:1130–1136
  7. Murali B, Umrani DN, Goyal RK. Effect of chronic treatment with losartan on streptozotocin-induced renal dysfunction. Mol. Cell. Biochem. 2003;249:85–90
  8. Davidson WD, Sackner MA. Simplification of the anthrone method for the determination of inulin in clearance studies. J. Lab. Clin. Med. 1963;62:351–356
  9. Santos SF, Vieira LM, Moura RS. Effect of high-salt intake on blood pressure and vascular reactivity of diabetic rats. Braz. J. Med. Biol. Res. 1995;28(8):889–894
  10. Maeda CY, Schaan BD, Oliveira EM, Oliveira VL, De Angelis K, Irigoyen MC. Chronic salt loading and cardiovascular-associated changes in experimental diabetes in rats. Clin. Exp. Pharmacol. Physiol. 2007;34:574–580
  11. Orie NN, Aloamaka CP, Iyawe VI. Enhanced sensitivity to salt-induced high blood pressure in diabetes mellitus. Res. Exp. Med. 1994;194(1):197–202
  12. Chan P, Wong K-L, Liu I-M, Tzeng T-F, Yang T-L, Cheng J-T. Antihyperglycemis action of angiotensin II receptor antagonist, valsartan, in streptozotocin-induced diabetic rats. J. Hypertens. 2003;21:761–769
  13. Freitas HS, Anhê GF, Melo KF, Okamoto MM, Oliveira-Souza M, Bordin S, et al. Na(+)-glucose transporter-2 messenger ribonucleic acid expression in kidney of diabetic rats correlates with glycemic levels: involvement of hepatocyte nuclear factor-1alpha expression and activity. Endocrinology. 2008;149(2):717–724

☆ This project was supported by the Mexican Council of Science and Technology (CONACYT), Research Grant 81359 to Dr. Bruno Escalante and CONACyT fellowship to Horacio Osorio.

PII: S0168-8227(09)00377-5

doi: 10.1016/j.diabres.2009.09.006

Diabetes Research and Clinical Practice
Volume 86, Issue 3 , Pages e46-e49 , December 2009

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