Diabetes Research and Clinical Practice
Volume 86, Issue 3 , Pages e46-e49, December 2009

Effect of treatment with losartan on salt sensitivity and SGLT2 expression in hypertensive diabetic rats☆

  • Horacio Osorio

      Affiliations

    • Department of Molecular Biomedicine, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV) México City, C.P. 07360, Mexico
    • ,
  • Rocío Bautista

      Affiliations

    • Department of Nephrology Instituto Nacional de Cardiología “Ignacio Chavez” México City, Mexico
    • ,
  • Amelia Rios

      Affiliations

    • CINVESTAV Monterrey, Nuevo León México, Mexico
    • ,
  • Martha Franco

      Affiliations

    • Department of Nephrology Instituto Nacional de Cardiología “Ignacio Chavez” México City, Mexico
    • ,
  • José Santamaría

      Affiliations

    • Department of Nephrology Instituto Nacional de Cardiología “Ignacio Chavez” México City, Mexico
    • ,
  • Bruno Escalante

      Affiliations

    • Department of Molecular Biomedicine, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV) México City, C.P. 07360, Mexico
    • CINVESTAV Monterrey, Nuevo León México, Mexico
    • Corresponding Author InformationCorresponding author at: CINVESTAV Monterrey, Vía del Conocimiento 201 Parque Investigación e Innovación Tecnológica, Apodaca NL CP 66600, Mexico. Tel.: +52 81 1156 1740.

Received 19 February 2009; received in revised form 24 August 2009; accepted 7 September 2009. published online 05 October 2009.

Abstract 

Sodium-glucose cotransporters (SGLTs) in the kidney, may be involved in hypertension, diabetes and salt sensitivity. We evaluate the effect of losartan on blood pressure (BP) and SGLT2 expression in diabetic rats with high or normal salt diet. Losartan prevented an increase in BP and SGLT2 expression in diabetic rats.

Keywords: Diabetes, Hypertension, Salt sensitivity, Kidney, SGLT2

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☆ This project was supported by the Mexican Council of Science and Technology (CONACYT), Research Grant 81359 to Dr. Bruno Escalante and CONACyT fellowship to Horacio Osorio.

PII: S0168-8227(09)00377-5

doi:10.1016/j.diabres.2009.09.006

Diabetes Research and Clinical Practice
Volume 86, Issue 3 , Pages e46-e49, December 2009

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