Diabetes Research and Clinical Practice
Volume 86, Issue 3 , Pages 186-192 , December 2009

Variation in the perilipin gene (PLIN) affects glucose and lipid metabolism in non-Hispanic white women with and without polycystic ovary syndrome

  • Toshihide Kawai

      Affiliations

    • Department of Medicine, The University of Chicago, Chicago, IL, USA
    • Corresponding Author InformationCorresponding author at: Department of Medicine, The University of Chicago, 5841 S. Maryland Ave., MC1027, Chicago, IL 60637, USA. Tel.: +1 773 702 9116; fax: +1 773 702 9237.
    • ,
  • Maggie C.Y. Ng

      Affiliations

    • Department of Medicine, The University of Chicago, Chicago, IL, USA
    • Department of Pediatrics, Section on Medical Genetics, and Centers for Human Genomics and Diabetes Research, Wake Forest University School of Medicine, Winston-Salem, NC, USA
    • ,
  • M. Geoffrey Hayes

      Affiliations

    • Department of Medicine, The University of Chicago, Chicago, IL, USA
    • ,
  • Issei Yoshiuchi

      Affiliations

    • Department of Medicine, The University of Chicago, Chicago, IL, USA
    • ,
  • Takafumi Tsuchiya

      Affiliations

    • Department of Medicine, The University of Chicago, Chicago, IL, USA
    • ,
  • Heather Robertson

      Affiliations

    • Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA
    • ,
  • Nancy J. Cox

      Affiliations

    • Department of Medicine, The University of Chicago, Chicago, IL, USA
    • Department of Human Genetics, The University of Chicago, Chicago, IL, USA
    • ,
  • Kenneth S. Polonsky

      Affiliations

    • Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA
    • ,
  • Graeme I. Bell

      Affiliations

    • Department of Medicine, The University of Chicago, Chicago, IL, USA
    • Department of Human Genetics, The University of Chicago, Chicago, IL, USA
    • ,
  • David A. Ehrmann

      Affiliations

    • Department of Medicine, The University of Chicago, Chicago, IL, USA

Received 11 July 2009 ,Revised 30 August 2009 ,Accepted 3 September 2009.

References 

  1. Knochenhauer E, Key T, Kahsar-Miller M, Waggoner W, Boots L, Azziz R. Prevalence of the polycystic ovary syndrome in unselected black and white women of the southeastern United States: a prospective study. J. Clin. Endocrinol. Metab. 1998;83:3078–3082
  2. Solomon CG. The epidemiology of polycystic ovary syndrome. Prevalence and associated disease risks. Endocrinol. Metab. Clin. North Am. 1999;28:247–263
  3. Azziz R, Woods KS, Reyna R, Key TJ, Knochenhauer ES, Yildiz BO. The prevalence and features of the polycystic ovary syndrome in an unselected population. J. Clin. Endocrinol. Metab. 2004;89:2745–2749
  4. Ehrmann DA. Polycystic ovary syndrome. N. Engl. J. Med. 2005;352:1223–1236
  5. Legro R, Driscoll D, Strauss J, Fox J, Dunaif A. Evidence for a genetic basis for hyperandrogenemia in polycystic ovary syndrome. Proc. Natl. Acad. Sci. U.S.A. 1998;95:14956–14960
  6. Legro RS, Bentley-Lewis R, Driscoll D, Wang SC, Dunaif A. Insulin resistance in the sisters of women with polycystic ovary syndrome: association with hyperandrogenemia rather than menstrual irregularity. J. Clin. Endocrinol. Metab. 2002;87:2128–2133
  7. Sam S, Legro RS, Essah PA, Apridonidze T, Dunaif A. Evidence for metabolic and reproductive phenotypes in mothers of women with polycystic ovary syndrome. Proc. Natl. Acad. Sci. U.S.A. 2006;103:7030–7035
  8. Hara M, Alcoser SY, Qaadir A, Beiswenger KK, Cox NJ, Ehrmann DA. Insulin resistance is attenuated in women with polycystic ovary syndrome with the Pro(12)Ala polymorphism in the PPARgamma gene. J. Clin. Endocrinol. Metab. 2002;87:772–775
  9. Ehrmann DA, Tang X, Yoshiuchi I, Cox NJ, Bell GI. Relationship of insulin receptor substrate-1 and -2 genotypes to phenotypic features of polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 2002;87:4297–4300
  10. Barber TM, Bennett AJ, Groves CJ, Sovio U, Ruokonen A, Martikainen H, et al. Association of variants in the fat mass and obesity associated (FT0) gene with polycystic ovary syndrome. Diabetologia. 2008;51:1153–1158
  11. Greenberg A, Egan J, Wek S, Garty N, Blanchette-Mackie E, Londos C. Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets. J. Biol. Chem. 1991;266:11341–11346
  12. Martinez-Botas J, Anderson J, Tessier D, Lapillonne A, Chang B, Quast M, et al. Absence of perilipin results in leanness and reverses obesity in Leprdb/db mice. Nat. Genet. 2000;26:474–479
  13. Tansey JT, Sztalryd C, Gruia-Gray J, Roush DL, Zee JV, Gavrilova O, et al. Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity. Proc. Natl. Acad. Sci. U.S.A. 2001;98:6494–6499
  14. Yan W, Chen S, Huang J, Shen Y, Qiang B, Gu D. Polymorphisms in PLIN and hypertension combined with obesity and lipid profiles in Han Chinese. Obes. Res. 2004;12:1733–1737
  15. Qi L, Shen H, Larson I, Schaefer EJ, Greenberg AS, Tregouet DA, et al. Gender-specific association of a perilipin gene haplotype with obesity risk in a white population. Obes. Res. 2004;12:1758–1765
  16. Qi L, Corella D, Sorli JV, Portoles O, Shen H, Coltell O, et al. Genetic variation at the perilipin (PLIN) locus is associated with obesity-related phenotypes in white women. Clin. Genet. 2004;66:299–310
  17. Qi L, Tai ES, Tan CE, Shen H, Chew SK, Greenberg AS, et al. Intragenic linkage disequilibrium structure of the human perilipin gene (PLIN) and haplotype association with increased obesity risk in a multiethnic Asian population. J. Mol. Med. 2005;83:448–456
  18. Corella D, Qi L, Sorli JV, Godoy D, Portoles O, Coltell O, et al. Obese subjects carrying the 11482G>A polymorphism at the perilipin locus are resistant to weight loss after dietary energy restriction. J. Clin. Endocrinol. Metab. 2005;90:5121–5126
  19. Jang Y, Kim OY, Lee JH, Koh SJ, Chae JS, Kim JY, et al. Genetic variation at the perilipin locus is associated with changes in serum free fatty acids and abdominal fat following mild weight loss. Int. J. Obes. (Lond.). 2006;30:1601–1608
  20. Corella D, Qi L, Tai ES, Deurenberg-Yap M, Tan CE, Chew SK, et al. Perilipin gene variation determines higher susceptibility to insulin resistance in Asian women when consuming a high-saturated fat, low-carbohydrate diet. Diabetes Care. 2006;29:1313–1319
  21. Kang ES, Cha BS, Kim HJ, Kim HJ, Kim SH, Hur KY, et al. The 11482G>A polymorphism in the perilipin gene is associated with weight gain with rosiglitazone treatment in type 2 diabetes. Diabetes Care. 2006;29:1320–1324
  22. Qi L, Zhang C, Greenberg A, Hu FB. Common variations in perilipin gene, central obesity, and risk of type 2 diabetes in US women. Obesity. 2008;16:1061–1065
  23. Deram S, Nicolau CY, Perez-Martinez P, Guazzelli I, Halpern A, Wajchenberg BL, et al. Effects of Perilipin (PLIN) gene variation on metabolic syndrome risk and weight loss in obese children and adolescents. J. Clin. Endocrinol. Metab. 2008;93:4933–4940
  24. American Diabetes Association . Diagnosis and classification of diabetes mellitus. Diabetes Care. 2008;31(Suppl. 1):S55–S60
  25. Carter KW, McCaskie PA, Palmer LJ. JLIN: a java based linkage disequilibrium plotter. BMC Bioinform. 2006;7:60
  26. Stephens M, Smith NJ, Donnelly P. A new statistical method for haplotype reconstruction from population data. Am. J. Hum. Genet. 2001;68:978–989
  27. Stephens M, Donnelly P. A comparison of bayesian methods for haplotype reconstruction from population genotype data. Am. J. Hum. Genet. 2003;73:1162–1169
  28. Brasaemle DL, Rubin B, Harten IA, Gruia-Gray J, Kimmel AR, Londos C. Perilipin A increases triacylglycerol strage by decreasing the rate of triacylglycerol hydrolysis. J. Biol. Chem. 2000;275:38486–38493
  29. Sztalryd C, Xu G, Dorward H, Tansey J, Contreras J, Kimmel A, et al. Perilipin A is essential for the translocation of hormone-sensitive lipase during lipolytic activation. J. Cell Biol. 2003;161:1093–1103
  30. Souza SC, de Vargas LM, Yamamoto MT, Lien P, Franciosa MD, Moss LG, et al. Overexpression of perilipin A and B blocks the ability of tumor necrosis factor alpha to increase lipolysis in 3T3-L1 adipocytes. J. Biol. Chem. 1998;273:24665–24669

PII: S0168-8227(09)00373-8

doi: 10.1016/j.diabres.2009.09.002

Diabetes Research and Clinical Practice
Volume 86, Issue 3 , Pages 186-192 , December 2009

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