« Previous
Next »
Diabetes Research and Clinical Practice
Volume 78, Issue 3,
Supplement
, Pages S14-S22
, 20 December 2007
Role of adipose tissue in the development of vascular complications in type 2 diabetes mellitus
References
- . Global and societal implications of the diabetes epidemic. Nature. 2001;414:782–787
- . Pathogenesis of diabetic complications. Nature. 2001;414:813–820
- . Postprandial hyperglycemia and diabetes complications: is time to treat?. Diabetes. 2005;54:1–7
- . A review of the microcirculation of adipose tissue: anatomic, metabolic and angiogenic perspectives. Microcirculation. 1997;4:211–232
- . Impact of obesity on metabolism in men and women: importance of regional adipose tissue distribution. J. Clin. Invest. 1983;72:1150–1162
- . Obesity is associated with macrophage accumulation in adipose tissue. J. Clin. Invest. 2003;112:1796–1808
- . Adipose tissue as an endocrine organ. Trends Endocrinol. Metab. 2000;11:327–332
- . The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation. Am. J. Physiol. 2001;280:E827–E847
- . Adipocyte expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance. Science. 1993;259:87–91
- . Omental and subcutaneous adipose tissues of obese subject release interleukin-6: depot difference and regulation by glucocorticoid. J. Clin. Endocrinol. Metab. 1998;83:847–850
- . Interleukin-8 production in human adipose tissue: inhibitory effect of anti-diabetic compounds, the thiazolidinendione ciglitazone and the biguanide metformin. Horm. Metab. Res. 2000;32:537–541
- . The proatherogonic cytokine interleukin-18 is secreted by human adipocytes. Eur. J. Endocrinol. 2005;152:863–868
- . Positional cloning of the mouse obese gene and its human homologue. Nature. 1994;372:425–432
- The hormone resistin links obesity to diabetes. Nature. 2001;409:307–312
- . A novel serum protein similar to C1q, produced exclusively in adipocytes. J. Biol. Chem. 1995;270:26746–26749
- Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science. 2005;307:426–430
- . Monocyte chemoattractant protein-1 is produced in isolated adipocytes, associated with adiposity and reduced after weight loss in morbidly obese subjects. Int. J. Obes. 2005;29:146–150
- Serum retinol binding protein contributes to insulin resistance and obesity in type 2 diabetes mellitus. Nature. 2005;436:356–362
- . Human adipose tissue expresses angiotensinogen and enzymes required for its conversion to angitensin II. J. Clin. Endocrinol. Metab. 1998;83:3925–3929
- . Enhanced expression of PAI-1 in visceral fat: possible contributor to vascular disease in obesity. Nat. Med. 1996;2:800–803
- . Subcutaneous and visceral adipose tissue; their relation to the metabolic syndrome. Endocr. Rev. 2000;21:697–738
- . Peroxisome proliferators activated receptors γ (PPARγ) and adipose tissue-understanding obesity-related changes in regulation of lipid and glucose metabolism. J. Clin. Endocrinol. Metab. 2007;92:386–395
- . The effects of PPARγ ligands on the adipose tissue in insulin resistance. Prostaglandins Leukot. Essent. Fatty Acids. 2005;73:65–75
- Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J. Clin. Invest. 2003;112:1821–1830
- . Fatty acid-induced inflammation and insulin resistance in skeletal muscle and liver. Curr. Diab. Rep. 2006;6:177–181
- . Control of hepatic gluconeogenesis: role of fatty acid oxidation. Arch. Biochem. Biophys. 1989;271:1–9
- . Obesity and insulin resistance. J. Clin. Invest. 2000;106:473–481
- Mechanism of free fatty acid-induced insulin resistance in humans. J. Clin. Invest. 1996;97:2859–2865
- . Effect of acute changes on plasma free fatty acids on intramyocellular fat content and insulin resistance in healthy subjects. Diabetes. 2001;50:1612–1617
- . Lipid-induced insulin resistance in human muscle is associated with changes in diacylglicerol, protein kinase C, and IkappaB-alpha. Diabetes. 2002;51:2005–2011
- Free fatty acid induced insulin resistance is associated with activation of protein kinase C θ and alterations in insulin signaling cascade. Diabetes. 1999;48:1270–1274
- Cellular mechanism of nutritionally induced insulin resistance in Psammomys obesus. Overexpression of protein kinase Cɛ in skeletal muscle precedes the onset of hyperinsulinemia and hyperglycemia. Diabetes. 2001;50:584–592
- . Prevention of ventricular fibrillation during acute myocardial ischemia: control of free fatty acids. J. Cardiovasc. Pharmacol. Ther. 2001;6:213–217
- Elevation of free fatty acids induces inflammation and impairs vascular reactivity in healthy subjects. Diabetes. 2003;52:2882–2887
- Free fatty acids are independently associated with all-cause and cardiovascular mortality in subjects with coronary artery disease. J. Clin. Endocrinol. Metab. 2006;91:2542–2547
- Serum immunoreactive-leptin concentration in normal-weight and obese humans. N. Engl. J. Med. 1996;334:292–295
- . Levels of leptin in plasma of patients with type 2 diabetes. Pol. Arch. Med. Wewn. 1998;99:470–476
- Effect of recombinant leptin therapy in a child with congenital leptin deficiency. N. Engl. J. Med. 1999;341:879–884
- . Peripheral metabolic actions of leptin. Best Pract. Res. Clin. Endocrinol. Metab. 2002;16:653–666
- . Human leptin: an adipocyte hormone with weight-regulatory and endocrine function. Semin. Vasc. Med. 2005;5:15–24
- . Leptin and atherosclerosis. Atherosclerosis. 2006;189:47–60
- Plasma leptin is independently associated with the intima media-thickness of the common carotid artery. Int. J. Obes. 2001;25:805–810
- . Plasma leptin and prognosis in patients with established coronary atherosclerosis. J. Am. Coll. Cardiol. 2004;44:1819–1829
- Plasma leptin levels are associated with coronary aterosclerosis in type 2 diabetes. J. Clin. Endocrinol. Metab. 2004;89:3782–3788
- Decreased resistin expression in mice with different sensitivities to a high-fat diet. Biochem. Biophys. Res. Commun. 2001;289:564–567
- Suppressed gene expression of adipocyte resistin in an insulin—resistant rat model probably by elevated free fatty acids. Biochem. Biophys. Res. Commun. 2001;289:1328–1333
- . Insulin resistance and type 2 diabetes are not related to resistin expression in human fat cells or skeletal muscle. Biochem. Biophys. Res. Commun. 2001;285:561–564
- Resistin/Fizz3 expression in relation to obesity and peroxisome proliferators-activated receptor-γ action in humans. Diabetes. 2001;50:2199–2202
- . Resistin gene expression in human adipocytes is not related to insulin resistance. Obes. Res. 2002;10:1–5
- Resistin is expressed in human macrophages and directly regulated by PPAR γ activators. Biochem. Biophys. Res. Commun. 2003;300:472–476
- Plasma resistin concentrations measured by enzyme-linked immunosorbent assay using a newly developed monoclonal antibody are elevated in individuals with type 2 diabetes mellitus. J. Clin. Endocrinol. Metab. 2004;89:150–156
- Resistin is not associated with insulin sensitivity or the metabolic syndrome in humans. Diabetologia. 2005;48:2330–2333
- . Plasma resistin levels in patients with type 1 and type 2 diabetes mellitus and in healthy controls. Horm. Metab. Res. 2002;34:671–673
- . Resistin an adipokine with potent proinflammatory cytokine properties. J. Immunol. 2005;174:5789–5795
- Resistin promotes endothelial cell activation: further evidence of adipokine–endothelial interaction. Circulation. 2003;187:736–740
- The potential role of resistin in atherogenesis. Atherosclerosis. 2005;182:241–248
- . Resistin is an inflammatory marker of atherosclerosis in humans. Circulation. 2005;111:932–939
- . Adiponectin: more than just another fat cell hormone?. Diab. Care. 2003;26:2442–2450
- Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature. 2003;423:762–769
- . Adiponectin and metabolic syndrome. Arterioscler. Thromb. Vasc. Biol. 2004;24:29–33
- Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. Diabetes. 2001;50:1126–1133
- Plasma concentration of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler. Thromb. Vasc. Biol. 2000;20:1595–1599
- Adiponectin and development of type 2 diabetes in the Pima Indian population (Letter). Lancet. 2002;360:57–58
- Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem. Biophys. Res. Commun. 1999;257:79–83
- . Association of hipoadiponectinemia with coronary artery disese in men. Arterioscler. Thromb. Vasc. Biol. 2003;23:85–89
- . Decreased plasma adiponectin concentrations in patients with essential hypertension. Am. J. Hypertens. 2003;16:72–75
- . Plasma adiponectin concentration and tumor necrosis factor-α system activity in lean non-diabetic offspring of type 2 diabetic subjects. Eur. J. Endocrinol. 2006;154:319–324
- The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat. Med. 2001;7:941–946
- . Metabolic stress and altered glucose transport: activation of AMP-activated protein kinase as a unifying coupling mechanism. Diabetes. 2000;49:527–531
- . AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes. Am. J. Physiol. 1999;277:E1–E10
- Adiponectin stimulates glucose utilization and fatty acid oxidation by activating AMP-activated protein kinase. Nat. Med. 2002;8:1288–1295
- Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation and low plasma concentration precedes a decrease in whole-body insulin sensitivity in humans. Diabetes. 2002;51:1884–1888
- . Plasma adiponectin levels and risk of myocardial infarction in men. JAMA. 2004;291:1730–1737
- The variation of plasma concentration of a novel, adipocyte derived protein, adiponectin, in patients with acute myocardial infarction. Heart. 2003;89:667–668
- Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice. Circulation. 2002;106:2767–2770
- . Adiponectin: a novel adipokine linking adipocytes and vascular function. J. Clin. Endocrinol. Metab. 2004;89:2563–2568
- Adiponectin, an adipocyte-derived plasma protein, inhbits endothelial NF-kappaB signaling through a cAMP-dependent pathway. Circulation. 2000;102:1296–1301
- Plasma adiponectin and E selectin concentrations in patients with coronary heart disease and newly diagnosed disturbances of glucose metabolism. Adv. Med. Sci. 2006;56:94–98
- Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2 dependent mechanism. Nat. Med. 2005;11:1096–1103
- Exacerbation of heart failure in adiponectin-deficient mice due to impaired regulation of AMPK and glucose metabolism. Cardiovasc. Res. 2005;67:705–713
- Adiponectin-mediated modulation of hypertrophic signals. Nat. Med. 2004;10:1384–1389
- . Cardioprotection by adiponectin. TCM. 2006;16:141–146
- . The tumor necrosis factor ligand and receptor families. N. Engl. J. Med. 1996;334:1717–1725
- . Increased adipose tissue expression of tumor necrosis factor-α in human obesity and insulin resistance. J. Clin. Invest. 1995;95:2409–2415
- . The expression of TNFα by human muscle: relationship to insulin resistance. J. Clin. Invest. 1996;97:1111–1116
- . IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNFα and obesity-induced insulin resistance. Science. 1996;271:665–668
- . Protection from obesity-induced insulin resistance in mice lacking TNFα function. Nature. 1997;389:610–614
- Skeletal muscle triglycerides lowering is associated with net improvement of insulin sensitivity, TNF-alpha reduction and GLUT4 expression enhancement. Int. J. Obes. 2002;26:1165–1172
- Interleukin-6 and tumor necrosis factor-alpha are not increased in patients with type 2 diabetes: evidence that plasma interleukin-6 is related to fat mass and not insulin responsiveness. Diabetologia. 2004;47:1029–1037
- . Differential regulation of the p80 tumor necrosis factor receptor in human obesity and insulin resistance. Diabetes. 1997;46:451–455
- Plasma levels of the soluble fraction of tumor necrosis factor receptor 2 and insulin resistance. Diabetes. 1998;47:1757–1762
- . Increased plasma-soluble tumor necrosis factor-alpha receptor 2 level in lean nondiabetic offspring of type 2 diabetic subjects. Diab. Care. 2002;25:1824–1828
- . Soluble tumor necrosis factor-alpha receptors in young obese subjects with normal and impaired glucose tolerance. Diab. Care. 2003;26:875–880
- Changes in tumor necrosis factor-alpha system and insulin sensitivity during an exercise training program in obese women with normal and impaired glucose tolerance. Eur. J. Endocrinol. 2001;145:273–280
- Postabsorptive and insulin-stimulated energy homeostasis and leucine turnover in offspring of type 2 diabetic patients. Diab. Care. 2004;27:2716–2722
- . Obesity, and not insulin resistance is the major determinant of serum inflammatory cardiovascular risk markers in pre-menopausal women. Diabetologia. 2003;46:625–633
- . Effects of an engineered human anti-TNFα antibody (CDP571) on insulin sensitivity and glycemic control in patients with NIDDM. Diabetes. 1996;45:881–885
- . No increased insulin sensitivity after a single intavenous administration of a recombinant human tumor necrosis factor receptor: Fc fusion protein in obese insulin-resistant patients. J. Clin. Endocrinol. Metab. 2000;85:1316–1319
- . Lowered tumor necrosis factor receptors, but not increased insulin sensitivity, with infliximab. Obes. Res. 2004;12:734–739
- . TNFα inhibits flow and insulin signaling leading to NO production in aortic endothelial cells. Am. J. Physiol. 2001;280:C1057–C1065
- . Acute impairment of insulin-mediated capillary recruitment and glucose uptake in rat skeletal muscle in vivo by TNFα. Diabetes. 2000;49:1904–1909
- Tumor necrosis factor system activity is associated with insulin resistance and dyslipidemia in myotonic dystrophy. Diabetes. 1999;48:1108–1112
- . Mast cells in rupture-prone areas of human coronary atheromas produce and store TNFα. Circulation. 1996;94:2787–2792
- . Interleukin-1β and tumor necrosis factor-α decrease collagen synthesis and increase matrix metalloproteinase activity in vitro. Circ. Res. 2000;86:1259–1265
- Expression of PAI-1 in human adipose tissue: a role for TNFα?. Atherosclerosis. 1999;143:81–90
- . Tumor necrosis factor mediates the effects of endotoxin on cholesterol and triglyceride metabolism in mice. Endocrinology. 1993;132:2246–2253
- . Plasma levels of the soluble fraction of TNFα receptors 1 and 2 are independent determinants of total and LDL-cholesterol concentrations in healthy subjects. Atherosclerosis. 1999;146:321–327
- Tumor necrosis factor-α stimulates ICAM-1 expression in human vascular smooth muscle cells. Arterioscler. Thromb. 1993;13:407–414
- . Elevated soluble intercellular adhesion molecule-1 levels in obesity: relationship to insulin resistance and tumor necrosis factor-alpha system activity. Metabolism. 2002;51:75–78
- . Plasma interleukin-8 concentrations are increased in obese subjects and related to fat mass and tumor necrosis factor-alpha system. J. Clin. Endocrinol. Metab. 2002;87:4602–4606
- Identification and characterization of a novel spliced variant that encodes human soluble tumor necrosis factor receptor 2. Int. Immunol. 2004;16:169–177
- An alternative spliced variant of circulating soluble tumor necrosis factor-alpha receptor-2 is paradoxically associated with insulin action. Eur. J. Endocrinol. 2006;154:723–730
- . An alternatively spliced soluble TNFα receptor is associated with metabolic disorders: a replication study. Clin. Immunol. 2006;121:236–241
PII: S0168-8227(07)00518-9
doi: 10.1016/j.diabres.2007.10.007
© 2007 Elsevier Ireland Ltd. All rights reserved.
« Previous
Next »
Diabetes Research and Clinical Practice
Volume 78, Issue 3,
Supplement
, Pages S14-S22
, 20 December 2007
