Diabetes Research and Clinical Practice
Volume 77, Issue 3 , Pages 363-370 , September 2007

Study of iron metabolism disturbances in an animal model of insulin resistance

  • Guillaume Le Guenno

      Affiliations

    • INRA, Equipe Stress Métabolique et Micronutriments, UNH, UMR 1019, Clermont-Ferrand/Theix, St-Genès-Champanelle 63122, France
    • Corresponding Author InformationCorresponding author at: 8 impasse Chabrier 63540 Romagnat, France. Tel.: +33 4 73 61 15 45; fax: +33 4 73 62 46 38.
    • ,
  • Emilie Chanséaume

      Affiliations

    • INRA, Equipe Métabolisme Lipidique et Energétique, UNH, UMR 1019, Clermont-Ferrand/Theix, St-Genès-Champanelle 63122, France
    • ,
  • Marc Ruivard

      Affiliations

    • Service of Internal Medicine Hôtel-dieu, C.H.U. Clermont Ferrand, France
    • ,
  • Béatrice Morio

      Affiliations

    • INRA, Equipe Métabolisme Lipidique et Energétique, UNH, UMR 1019, Clermont-Ferrand/Theix, St-Genès-Champanelle 63122, France
    • ,
  • Andrzej Mazur

      Affiliations

    • INRA, Equipe Stress Métabolique et Micronutriments, UNH, UMR 1019, Clermont-Ferrand/Theix, St-Genès-Champanelle 63122, France

Received 24 October 2006 ,Accepted 10 February 2007.

References 

  1. Haap M, Fritsche A, Mensing HJ, Haring HU, Stumvoll M. Association of high serum ferritin concentration with glucose intolerance and insulin resistance in healthy people. Ann. Intern. Med. 2003;139:869–871
  2. Jehn M, Clark JM, Guallar E. Serum ferritin and risk of the metabolic syndrome in U.S. adults. Diab. Care. 2004;27:2422–2428
  3. Tuomainen TP, Nyyssonen K, Salonen R, Tervahauta A, Korpela H, Lakka T, et al. Body iron stores are associated with serum insulin and blood glucose concentrations. Population study in 1,013 eastern Finnish men. Diab. Care. 1997;20:426–428
  4. Salonen JT, Tuomainen TP, Nyyssonen K, Lakka HM, Punnonen K. Relation between iron stores and non-insulin dependent diabetes in men: case–control study. BMJ. 1998;317:727
  5. Fernandez-Real JM, Ricart-Engel W, Arroyo E, Balanca R, Casamitjana-Abella R, Cabrero D, et al. Serum ferritin as a component of the insulin resistance syndrome. Diab. Care. 1998;21:62–68
  6. Fernandez-Real JM, Penarroja G, Castro A, Garcia-Bragado F, Hernandez-Aguado I, Ricart W. Blood letting in high-ferritin type 2 diabetes: effects on insulin sensitivity and beta-cell function. Diabetes. 2002;51:1000–1004
  7. Borel MJ, Beard JL, Farrell PA. Hepatic glucose production and insulin sensitivity and responsiveness in iron-deficient anemic rats. Am. J. Physiol. 1993;264:E380–E390
  8. Moirand R, Mortaji AM, Loreal O, Paillard F, Brissot P, Deugnier Y. A new syndrome of liver iron overload with normal transferrin saturation. Lancet. 1997;349:95–97
  9. Guillygomarc’h A, Mendler MH, Moirand R, Laine F, Quentin V, David V, et al. Venesection therapy of insulin resistance-associated hepatic iron overload. J. Hepatol. 2001;35:344–349
  10. Bozzini C, Girelli D, Olivieri O, Martinelli N, Bassi A, De Matteis G, et al. Prevalence of body iron excess in the metabolic syndrome. Diab. Care. 2005;28:2061–2063
  11. Failla ML, Kennedy ML, Chen ML. Iron metabolism in genetically obese (ob/ob) mice. J. Nutr. 1988;118:46–51
  12. Kennedy ML, Failla ML, Smith JC. Influence of genetic obesity on tissue concentrations of zinc, copper, manganese and iron in mice. J. Nutr. 1986;116:1432–1441
  13. Serfass RE, Park KE, Kaplan ML. Developmental changes of selected minerals in Zucker rats. Proc. Soc. Exp. Biol. Med. 1988;189:229–239
  14. Krause A, Neitz S, Magert HJ, Schulz A, Forssmann WG, Schulz-Knappe P, et al. LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. FEBS Lett. 2000;480:147–150
  15. Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 2004;306:2090–2093
  16. Nicolas G, Chauvet C, Viatte L, Danan JL, Bigard X, Devaux I, et al. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J. Clin. Invest. 2002;110:1037–1044
  17. Vokurka M, Krijt J, Sulc K, Necas E. Hepcidin mRNA levels in mouse liver respond to inhibition of erythropoïesis. Physiol. Res. 2006;
  18. Tanner LI, Lienhard GE. Insulin elicits a redistribution of transferrin receptors in 3T3-L1 adipocytes through an increase in the rate constant for receptor externalization. J. Biol. Chem. 1987;262:8975–8980
  19. Tanner LI, Lienhard GE. Localization of transferrin receptors and insulin-like growth factor II receptors in vesicles from 3T3-L1 adipocytes that contain intracellular glucose transporters. J. Cell Biol. 1989;108:1537–1545
  20. Nestler JE, Clore JN, Failla ML, Blackard WG. Effects of extreme hyperinsulinaemia on serum levels of trace metals, trace metal binding proteins, and electrolytes in normal females. Acta Endocrinol. (Copenh.). 1987;114:235–242
  21. Foy AL, Williams HL, Cortell S, Conrad ME. A modified procedure for the determination of nonheme iron in tissue. Anal. Biochem. 1967;18:559–563
  22. Simpson RJ, Lombard M, Raja KB, Thatcher R, Peters TJ. Iron absorption by hypotransferrinaemic mice. Br. J. Haematol. 1991;78:565–570
  23. Hegarty BD, Cooney GJ, Kraegen EW, Furler SM. Increased efficiency of fatty acid uptake contributes to lipid accumulation in skeletal muscle of high fat-fed insulin-resistant rats. Diabetes. 2002;51:1477–1484
  24. Kraegen EW, Clark PW, Jenkins AB, Daley EA, Chisholm DJ, Storlien LH. Development of muscle insulin resistance after liver insulin resistance in high-fat-fed rats. Diabetes. 1991;40:1397–1403
  25. Akiyama T, Tachibana I, Shirohara H, Watanabe N, Otsuki M. High-fat hypercaloric diet induces obesity, glucose intolerance and hyperlipidemia in normal adult male Wistar rat. Diab. Res. Clin. Pract. 1996;31:27–35
  26. Facchini FS, Carantoni M, Jeppesen J, Reaven GM, Hematocrit . haemoglobin are independently related to insulin resistance and compensatory hyperinsulinemia in healthy, non-obese men and women. Metabolism. 1998;47:831–835
  27. Barbieri M, Ragno E, Benvenuti E, Zito GA, Corsi A, Ferrucci L, et al. New aspects of the insulin resistance syndrome: impact on haematological parameters. Diabetologia. 2001;44:1232–1237
  28. Bennett BD, Solar GP, Yuan JQ, Mathias J, Thomas GR, Matthews W. A role for leptin and its cognate receptor in hematopoiesis. Curr. Biol. 1996;6:1170–1180
  29. Park CH, Valore EV, Waring AJ, Ganz T. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J. Biol. Chem. 2001;276:7806–7810
  30. Korac A, Verec M, Davidovic V. Insulin-induced iron loading in the rat brown adipose tissue: histochemical and electron-microscopic study. Eur. J. Histochem. 2003;47:241–244

PII: S0168-8227(07)00111-8

doi: 10.1016/j.diabres.2007.02.004

Diabetes Research and Clinical Practice
Volume 77, Issue 3 , Pages 363-370 , September 2007

Article Tools

* Image Usage & Resolution