Diabetes Research and Clinical Practice
Volume 77, Issue 3 , Pages 357-362, September 2007

Glutathione suppresses increase of serum creatine kinase in experimental hypoglycemia

  • Zhongli Jiang

      Affiliations

    • Department of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
    • Department of Internal Medicine and Rehabilitation Science, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan
    • ,
  • Masahiro Kohzuki

      Affiliations

    • Department of Internal Medicine and Rehabilitation Science, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 22 717 7353; fax: +81 22 717 7355.
    • ,
  • Taku Harada

      Affiliations

    • Department of Internal Medicine and Rehabilitation Science, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan
    • ,
  • Tokutaro Sato

      Affiliations

    • National Rehabilitation Center for Persons with Disabilities, 4-1, Namiki, Tokorozawa, Saitama 359-8555, Japan

Received 20 February 2006; received in revised form 10 November 2006; accepted 10 January 2007. published online 28 February 2007.

Abstract 

Inhibitory effects of reduced glutathione (GSH) on serum enzymes including alanine aminotransferase (AST), lactate dehydrogenase (LDH) and creatine kinase (CK) were investigated in the hypoglycemic rabbits. Hypoglycemia lasting for 60min was induced by intravenous injection of insulin (10U/kg) and then recovered by intravenous glucose injection. Serum levels of ALT, AST, LDH and CK increased significantly (p<0.05) at 6h after the induction of hypoglycemia. Plasma GSH, oxidized glutathione (GSSG) and total glutathione (TGSH) began to increase significantly (p<0.05) at 1h after the insulin injection, and GSSG/TGSH ratio rose significantly (p<0.05) at 6h after the induction of hypoglycemia. GSSG contents and GSSG/TGSH ratio in quadriceps significantly increased during hypoglycemia. Administration of GSH significantly decreased plasma GSSG levels, GSSG/TGSH ratio (p<0.05) and suppressed the rise of serum enzymes induced by hypoglycemia. These results suggest that GSH administration may play a preventive role for increases of serum enzymes by experimental hypoglycemia.

Keywords: Hypoglycemia, Glutathione, Creatine kinase

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PII: S0168-8227(07)00052-6

doi:10.1016/j.diabres.2007.01.014

Diabetes Research and Clinical Practice
Volume 77, Issue 3 , Pages 357-362, September 2007

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