Correlations of urinary albumin excretion and atherosclerosis in Japanese type 2 diabetic patients

Anan, Futoshi; Masaki, Takayuki; Umeno, Yoshikazu; Fukunaga, Naoya; Teshima, Yasushi; Iwao, Tetsu; Kaneda, Koji; Yonemochi, Hidetoshi; Eshima, Nobuoki; Saikawa, Tetsunori; Yoshimatsu, Hironobu

doi:10.1016/j.diabres.2007.01.009

« Previous Next »Diabetes Research and Clinical Practice
Volume 77, Issue 3 , Pages 414-419, September 2007

Correlations of urinary albumin excretion and atherosclerosis in Japanese type 2 diabetic patients

Futoshi Anan
- Department of Cardiology, Oita Red Cross Hospital, Oita, Japan
- First Department of Internal Medicine, School of Medicine, Oita University, Oita, Japan
- Corresponding author at: Department of Cardiology, Oita Red Cross Hospital, 3-2-37 Chiyomachi, Oita 870-0033, Japan. Tel.: +81 97 532 6181; fax: +81 97 533 1207.
Takayuki Masaki
- First Department of Internal Medicine, School of Medicine, Oita University, Oita, Japan
Yoshikazu Umeno
- Department of Internal Medicine, Oita Red Cross Hospital, Oita, Japan
Naoya Fukunaga
- Department of Cardiology, Oita Red Cross Hospital, Oita, Japan
Yasushi Teshima
- Department of Cardiology, Oita Red Cross Hospital, Oita, Japan
Tetsu Iwao
- Department of Cardiology, Oita Red Cross Hospital, Oita, Japan
Koji Kaneda
- Department of Cardiology, Oita Red Cross Hospital, Oita, Japan
Hidetoshi Yonemochi
- Department of Cardiovascular Science, School of Medicine, Oita University, Oita, Japan
Nobuoki Eshima
- Department of Biostatistics, School of Medicine, Oita University, Oita, Japan
Tetsunori Saikawa
- Department of Cardiovascular Science, School of Medicine, Oita University, Oita, Japan
Hironobu Yoshimatsu
- First Department of Internal Medicine, School of Medicine, Oita University, Oita, Japan

Received 30 August 2006; received in revised form 22 December 2006; accepted 4 January 2007. published online 22 February 2007.

Abstract

Microalbuminuria and aortic stiffness are associated with high mortality in type 2 diabetic patients. We tested the hypothesis that the presence of microalbuminuria correlates with aortic stiffness and insulin resistance in type 2 diabetic patients.

The study consisted of 36 Japanese patients with type 2 diabetes and microalbuminuria (age: 56±9 years, mean±S.D.) and a control group of 44 age-matched patients with normoalbuminuria (56±7 years). Brachial-ankle pulse wave velocity (BaPWV) was measured by automatic oscillometric method. BaPWV was used as an index of atherosclerosis.

The BaPWV was higher in the microalbuminuria group than in the normoalbuminuria group (p<0.005). Fasting plasma glucose (p<0.05) and insulin concentrations (p<0.005), and the homeostasis model assessment (HOMA) index (p<0.0005), were higher in the microalbuminuria group than in the normoalbuminuria group. Multiple regression analysis showed that urinary albumin excretion was independently predicted by BaPWV and HOMA index.

Our results indicate that the presence of microalbuminuria in Japanese patients with type 2 diabetes is characterized by increased aortic stiffness and insulin resistance, and that the BaPWV, HOMA index are independent predictors of urine albumin excretion.

Keywords: Microalbuminuria, Insulin resistance, Aortic stiffness, Brachial-ankle pulse wave velocity, Type 2 diabetes mellitus