Diabetes Research and Clinical Practice
Volume 77, Issue 3 , Pages 385-388, September 2007

Haptoglobin polymorphism and diabetic retinopathy in Brazilian patients

  • Vânia P.A. Wobeto

      Affiliations

    • Department of Clinical Pathology, School of Medical Sciences, State University of Campinas, UNICAMP, Campinas, SP, Brazil
    • ,
  • Endrigo T. Rosim

      Affiliations

    • Department of Clinical Pathology, School of Medical Sciences, State University of Campinas, UNICAMP, Campinas, SP, Brazil
    • ,
  • Mônica B. Melo

      Affiliations

    • Laboratory of Molecular Medicine, School of Medical Sciences, Santa Casa de São Paulo, São Paulo, SP, Brazil
    • ,
  • Luís Eduardo P Calliari

      Affiliations

    • Pediatric Endocrinology Unit, Department of Pediatrics, Irmandade da Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brazil
    • ,
  • Maria de Fátima Sonati

      Affiliations

    • Department of Clinical Pathology, School of Medical Sciences, State University of Campinas, UNICAMP, Campinas, SP, Brazil
    • Corresponding Author InformationCorresponding author at: Department of Clinical Pathology, School of Medical Sciences, State University of Campinas, UNICAMP, Campinas, P.O. Box 6111, Zip Code 13083-970, State of São Paulo, Brazil. Tel.: +55 19 3521 9451; fax: +55 19 3521 9434.

Received 15 December 2006; accepted 29 December 2006. published online 05 February 2007.

Abstract 

Haptoglobin (Hp) is an acute phase protein with antioxidant and immunomodulatory properties. Three main genotypes/phenotypes (Hp1-1, Hp2-1 and Hp2-2) show distinct efficiencies in these activities and have been associated with susceptibility and outcome in several diseases, including diabetes mellitus (DM). It has been suggested that Hp polymorphism may influence the development of retinopathy, an important microvascular complication in DM. In order to investigate this association in a Brazilian population, we determined the Hp genotypes of 317 diabetic patients with at least 10 years of disease. The patients were classified as DM-type 1 and 2, with and without diabetic retinopathy (DR). The Hp genotype frequencies of the different patient groups and of a control group consisting of 142 healthy individuals who had previously been studied were compared. No significant differences were observed for the three Hp genotypes. Hemoglobin A1c levels, systolic blood pressure (SBP), diastolic blood pressure (DBP) and duration of diabetes, which are potential risk factors for DR, were also compared. Again no significant differences were observed for the three Hp genotypes. Thus, we conclude that this polymorphism is not associated with the presence of DR in the Brazilian population studied here.

Keywords: Haptoglobin genotypes, Diabetes mellitus, Diabetic retinopathy, Genetic polymorphisms, Brazilian population

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PII: S0168-8227(07)00005-8

doi:10.1016/j.diabres.2006.12.018

Diabetes Research and Clinical Practice
Volume 77, Issue 3 , Pages 385-388, September 2007

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