Diabetes Research and Clinical Practice
Volume 77, Issue 3 , Pages 377-384, September 2007

Estimation of influence of gastric emptying on shape of glucose concentration–time profile measured in oral glucose tolerance test

  • Ladislav Dedík

      Affiliations

    • Faculty of Mechanical Engineering, Slovak University of Technology, Bratislava, Slovak Republic
    • Corresponding Author InformationCorresponding author at: Faculty of Mechanical Engineering, Slovak University of Technology, Nám. Slobody 17, 812 31 Bratislava, Slovak Republic. Tel.: +421 2 57294559; fax: +421 2 57294559.
    • ,
  • Mária Ďurišová

      Affiliations

    • Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Slovak Republic
    • ,
  • Adela Penesová

      Affiliations

    • Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovak Republic
    • ,
  • Daniela Miklovičová

      Affiliations

    • Medical School of Comenius University, Bratislava, Slovak Republic
    • ,
  • Martina Tvrdoňová

      Affiliations

    • Faculty of Mechanical Engineering, Slovak University of Technology, Bratislava, Slovak Republic

Received 8 September 2006; accepted 29 December 2006. published online 31 January 2007.

Abstract 

Aims

To develop a model for simulations of processes in the oral glucose tolerance test (OGTT), using tools of the theory of dynamic systems.

Methods

Frequent sampling OGTT was performed in 13 healthy subjects (6 males and 7 females). Subsequently, employing glucose and insulin concentration–time profiles of the subjects, the model was developed.

Results

In all subjects the model was able to simulate influences of the insulin plasma concentration and gastric emptying rate on glucose concentration and to determine time profiles of glucose fractions retained in stomach.

Conclusions

The approach presented represents an opportunity for building models for data analyses in OGTT.

Keywords: OGTT, Glucose, Insulin, Model, Gastric emptying rate, System approach

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S0168-8227(07)00004-6

doi:10.1016/j.diabres.2006.12.017

Diabetes Research and Clinical Practice
Volume 77, Issue 3 , Pages 377-384, September 2007

Article Tools

* Image Usage & Resolution