Diabetes Research and Clinical Practice
Volume 77, Issue 1 , Pages 58-61 , July 2007

Association of sulfonylurea receptor 1 genotype with therapeutic response to gliclazide in type 2 diabetes

  • Huijuan Zhang

      Affiliations

    • Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China
    • Corresponding Author InformationCorresponding author at: c/o Mr. Wei Sun, 145 Nan-Tong Street, School of Economics and Management, Harbin Engineering University, Harbin 150001, China.
    • ,
  • Xiaomin Liu

      Affiliations

    • Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China
    • ,
  • Hongyu Kuang

      Affiliations

    • Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China
    • ,
  • Ran Yi

      Affiliations

    • Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China
    • ,
  • Houxun Xing

      Affiliations

    • Institute of Biomedicine, Anhui Medical University, Hefei 230032, China

Received 31 January 2006 ,Revised 10 September 2006 ,Accepted 6 October 2006.

References 

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  2. Szoke E, Gerich JE. Role of impaired insulin secretion and insulin resistance in the pathogenesis of type 2 diabetes mellitus. Compr. Ther. 2005;31:106–112
  3. Hansen T, Echwald SM, Hansen L, Moller AM, Almind K, Clausen JO, et al. Decreased tolbutamide-stimulated insulin secretion in healthy subjects with sequence variants in the high-affinity sulfonylurea receptor gene. Diabetes. 1998;47:598–605
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  11. Schulze MB, Hu FB. Primary prevention of diabetes: what can be done and how much can be prevented?. Annu. Rev. Public Health. 2005;26:445–467
  12. Daimon M, Ji G, Saitoh T, Oizumi T, Tominaga M, Nakamura T, et al. Large-scale search of SNPs for type 2 DM susceptibility genes in a Japanese population. Biochem. Biophys. Res. Commun. 2003;302:751–758
  13. Boileau P, Wolfrum C, Shih DQ, Yang TA, Wolkoff AW, Stoffel M. Decreased glibenclamide uptake in hepatocytes of hepatocyte nuclear factor-1alpha-deficient mice: a mechanism for hypersensitivity to sulfonylurea therapy in patients with maturity-onset diabetes of the young, type 3 (MODY3). Diabetes. 2002;51:S343–S348
  14. Nichols CG, Koster JC. Diabetes and insulin secretion: whither KATP?. Am. J. Physiol. Endocrinol. Metab. 2002;283:E403–E412
  15. Goksel DL, Fischbach K, Duggirala R, Mitchell BD, Aguilar-Bryan L, Blangero J, et al. Variant in sulfonylurea receptor-1 gene is associated with high insulin concentrations in non-diabetic Mexican Americans: SUR-1 gene variant and hyperinsulinemia. Hum. Genet. 1998;103:280–285
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PII: S0168-8227(06)00492-X

doi: 10.1016/j.diabres.2006.10.021

Diabetes Research and Clinical Practice
Volume 77, Issue 1 , Pages 58-61 , July 2007

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