Diabetes Research and Clinical Practice
Volume 77, Issue 1 , Pages 41-46 , July 2007

Oligomeric procyanidins of French maritime pine bark extract (Pycnogenol®) effectively inhibit α-glucosidase

Received 12 August 2006 ,Accepted 2 October 2006.

References 

  1. Roglic G, Unwin N, Bennett PH, Mathers C, Tuomilehto J, Nag S, et al. The burden of mortality attributable to diabetes: realistic estimates for the year 2000. Diab. Care. 2005;28:2130–2135
  2. Bazzano LA, Serdula M, Liu S. Prevention of type 2 diabetes by diet and lifestyle modification. J. Am. Coll. Nutr. 2005;24:310–319
  3. Vuksan V, Sievenpiper JL. Herbal remedies in the management of diabetes: lessons learned from the study of ginseng. Nutr. Metab. Cardiovasc. Dis. 2005;15:149–160
  4. Liu JP, Zhang M, Wang WY, Grimsgaard S. Chinese herbal medicines for type 2 diabetes mellitus. Cochrane Database Syst. Rev. 2004;CD003642
  5. Heacock PM, Hertzler SR, Williams JA, Wolf BW. Effects of a medical food containing an herbal alpha-glucosidase inhibitor on postprandial glycemia and insulinemia in healthy adults. J. Am. Diet. Assoc. 2005;105:65–71
  6. Youn JY, Park HY, Cho KH. Anti-hyperglycemic activity of Commelina communis L.: inhibition of alpha-glucosidase. Diab. Res. Clin. Pract. 2004;66(Suppl. 1):S149–S155
  7. Khan A, Safdar M, Ali Khan MM, Khattak KN, Anderson RA. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diab. Care. 2003;26:3215–3218
  8. Clarke P, Gray A, Adler A, Stevens R, Raikou M, Cull C, et al. Cost-effectiveness analysis of intensive blood-glucose control with metformin in overweight patients with type II diabetes (UKPDS No. 51). Diabetologia. 2001;44:298–304
  9. Vijayakumar MV, Singh S, Chhipa RR, Bhat MK. The hypoglycaemic activity of fenugreek seed extract is mediated through the stimulation of an insulin signalling pathway. Br. J. Pharmacol. 2005;146:41–48
  10. Hoa NK, Phan DV, Thuan ND, Ostenson CG. Insulin secretion is stimulated by ethanol extract of Anemarrhena asphodeloides in isolated islet of healthy Wistar and diabetic Goto-Kakizaki Rats. Exp. Clin. Endocrinol. Diab. 2004;112:520–525
  11. Chen TH, Chen SC, Chan P, Chu YL, Yang HY, Cheng JT. Mechanism of the hypoglycemic effect of stevioside, a glycoside of Stevia rebaudiana. Planta Med. 2005;71:108–113
  12. Gholap S, Kar A. Hypoglycaemic effects of some plant extracts are possibly mediated through inhibition in corticosteroid concentration. Pharmazie. 2004;59:876–878
  13. Eddouks M, Jouad H, Maghrani M, Lemhadri A, Burcelin R. Inhibition of endogenous glucose production accounts for hypoglycemic effect of Spergularia purpurea in streptozotocin mice. Phytomedicine. 2003;10:594–599
  14. Huang TH, Kota BP, Razmovski V, Roufogalis BD. Herbal or natural medicines as modulators of peroxisome proliferator-activated receptors and related nuclear receptors for therapy of metabolic syndrome. Basic Clin. Pharmacol. Toxicol. 2005;96:3–14
  15. Huang TH, Peng G, Kota BP, Li GQ, Yamahara J, Roufogalis BD, et al. Anti-diabetic action of Punica granatum flower extract: activation of PPAR-gamma and identification of an active component. Toxicol. Appl. Pharmacol. 2005;207:160–169
  16. Kobayashi Y, Suzuki M, Satsu H, Arai S, Hara Y, Suzuki K, et al. Green tea polyphenols inhibit the sodium-dependent glucose transporter of intestinal epithelial cells by a competitive mechanism. J. Agric. Food Chem. 2000;48:5618–5623
  17. Matsui T, Ebuchi S, Kobayashi M, Fukui K, Sugita K, Terahara N, et al. Anti-hyperglycemic effect of diacylated anthocyanin derived from Ipomoea batatas cultivar Ayamurasaki can be achieved through the alpha-glucosidase inhibitory action. J. Agric. Food Chem. 2002;50:7244–7248
  18. Kim YM, Jeong YK, Wang MH, Lee WY, Rhee HI. Inhibitory effect of pine extract on alpha-glucosidase activity and postprandial hyperglycemia. Nutrition. 2005;21:756–761
  19. Maritime Pine Extract in United States Pharmacopeia, United States Pharmacopeial Convention, Inc., Rockville, 2005, pp. 2115–2116.
  20. Rohdewald P. A review of the French maritime pine bark extract (Pycnogenol), a herbal medication with a diverse clinical pharmacology. Int. J. Clin. Pharmacol. Ther. 2002;40:158–168
  21. Liu X, Wei J, Tan F, Zhou S, Wurthwein G, Rohdewald P. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci. 2004;75:2505–2513
  22. Liu X, Zhou HJ, Rohdewald P. French maritime pine bark extract Pycnogenol dose-dependently lowers glucose in type 2 diabetic patients. Diab. Care. 2004;27:839
  23. Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (NC-IUBMB), 2005, http://www.chem.qmul.ac.uk/iubmb/enzyme/.
  24. Van de Laar FA, Lucassen PL, Akkermans RP, Van de Lisdonk EH, Rutten GE, Van Weel C. Alpha-glucosidase inhibitors for patients with type 2 diabetes: results from a Cochrane systematic review and meta-analysis. Diab. Care. 2005;28:154–163
  25. Matsui T, Yoshimoto C, Osajima K, Oki T, Osajima Y. In vitro survey of alpha-glucosidase inhibitory food components. Biosci. Biotechnol. Biochem. 1996;60:2019–2022
  26. Oki T, Matsui T, Osajima Y. Inhibitory effect of alpha-glucosidase inhibitors varies according to its origin. J. Agric. Food Chem. 1999;47:550–553
  27. Blazsó G, Gabor M, Sibbel R, Rohdewald P. Anti-inflammatory and superoxide radical scavenging activities of procyaninidins-containing extract from the bark of Pinus pinaster sol and its fractions. Pharm. Pharmacol. Lett. 1994;3:217–220
  28. Blazsó G, Gabor M, Rohdewald P. Antiinflammatory activities of procyanidin-containing extracts from Pinus pinaster Ait. after oral and cutaneous application. Pharmazie. 1997;52:380–382
  29. Kim MJ, Lee SB, Lee HS, Lee SY, Baek JS, Kim D, et al. Comparative study of the inhibition of alpha-glucosidase, alpha-amylase, and cyclomaltodextrin glucanosyltransferase by acarbose, isoacarbose, and acarviosine-glucose. Arch. Biochem. Biophys. 1999;371:277–283
  30. Kim JS, Kwon CS, Son KH. Inhibition of alpha-glucosidase and amylase by luteolin, a flavonoid. Biosci. Biotechnol. Biochem. 2000;64:2458–2461
  31. Kim YM, Wang MH, Rhee HI. A novel alpha-glucosidase inhibitor from pine bark. Carbohydr. Res. 2004;339:715–717
  32. Tsuneki H, Ishizuka M, Terasawa M, Wu JB, Sasaoka T, Kimura I. Effect of green tea on blood glucose levels and serum proteomic patterns in diabetic (db/db) mice and on glucose metabolism in healthy humans. BMC Pharmacol. 2004;4:18
  33. Grimm T, Schäfer A, Högger P. Antioxidant activity and inhibition of matrix metalloproteinases by metabolites of maritime pine bark extract (Pycnogenol). Free Radic. Biol. Med. 2004;36:811–822
  34. Düweler KG, Rohdewald P. Urinary metabolites of French maritime pine bark extract in humans. Pharmazie. 2000;55:364–368
  35. Grimm T, Skrabala R, Chovanova Z, Muchova J, Sumegova K, Liptakova A, et al. Single and multiple dose pharmacokinetics of maritime pine bark extract (Pycnogenol) after oral administration to healthy volunteers. BMC Clin. Pharmacol. 2006;6:4
  36. Grimm T, Chovanova Z, Muchova J, Sumegova K, Liptakova A, Durackova Z, et al. Inhibition of NF-kappaB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol). J. Inflamm. (Lond.). 2006;3:1
  37. Schäfer A, Chovanova Z, Muchova J, Sumegova K, Liptakova A, Durackova Z, et al. Inhibition of COX-1 and COX-2 activity by plasma of human volunteers after ingestion of French maritime pine bark extract (Pycnogenol). Biomed. Pharmacother. 2006;60:5–9

PII: S0168-8227(06)00456-6

doi: 10.1016/j.diabres.2006.10.011

Diabetes Research and Clinical Practice
Volume 77, Issue 1 , Pages 41-46 , July 2007

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