Diabetes Research and Clinical Practice
Volume 76, Issue 3 , Pages 418-424 , June 2007

Familial aggregation of metabolic syndrome among the Chinese: Report from the Chin-Shan community family study

  • K.L. Chien

      Affiliations

    • Institute of Preventive Medicine, School of Public Health, National Taiwan University, Taipei, Taiwan
    • Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
  • ,
  • H.C. Hsu

      Affiliations

    • Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
  • ,
  • W.J. Chen

      Affiliations

    • Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
  • ,
  • M.F. Chen

      Affiliations

    • Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
  • ,
  • T.C. Su

      Affiliations

    • Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
  • ,
  • Y.T. Lee

      Affiliations

    • Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    • Ming-Shen Healthcare, Taoyuang, Taiwan
    • Corresponding Author InformationCorresponding author. Tel.: +886 2 2356 2038; fax: +886 2 2392 0456.

Received 30 April 2006 ,Accepted 20 September 2006.

References 

  1. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1. Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabetic. Med. 1998;15:539–553
  2. Chen WJ, Liu PH, Ho YY, Chien KL, Lo MT, Shih WL, et al. Sibling recurrence risk ratio analysis of the metabolic syndrome and its components over time. BMC Genet. 2003;4(Suppl. 1):S33–S38
  3. Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA. 2002;287:356–359
  4. Al Lawati JA, Mohammed AJ, Al Hinai HQ, Jousilaht P. Prevalence of the metabolic syndrome among Omani adults. Diabetes Care. 2003;26:1781–1785
  5. Ramachandran A, Snehalatha C, Satyavani K, Sivasankari S, Vijay V. Metabolic syndrome in urban Asian Indian adults—a population study using modified ATP III criteria. Diabetes Res. Clin. Pract. 2003;60:199–204
  6. Tregouet DA, Herbeth B, Juhan-Vague I, Siest G, Ducimetiere P, Tiret L. Bivariate familial correlation analysis of quantitative traits by use of estimating equations: application to a familial analysis of the insulin resistance syndrome. Genet. Epidemiol. 1999;16:69–83
  7. Poulsen P, Vaag A, Kyvik K, Beck-Nielsen H. Genetic versus environmental aetiology of the metabolic syndrome among male and female twins. Diabetologia. 2001;44:537–543
  8. Austin MA, Edwards KL, McNeely MJ, Chandler WL, Leonetti DL, Talmud PJ. Heritability of multivariate factors of the metabolic syndrome in nondiabetic Japanese Americans. Diabetes. 2004;53:1166–1169
  9. Risch N, Merikangas K. The future of genetic studies of complex human diseases. Science. 1996;273:1516–1517
  10. Chien KL, Hsu HC, Su TC, Lee YT. Consistency in genetic inheritance mode and heritability patterns of triglyceride vs. high density lipoprotein cholesterol ratio in two Taiwanese family samples. BMC J.: Genet. 2003;4:7–16
  11. Chien KL, Chen WJ, Hsu HC, Su TC, Chen MF, Lee YT. Major gene effects in systolic and diastolic blood pressure in the families receiving health examination in Taiwan. J. Hypertens. 2003;21:1–7
  12. Lee YT, Lin RS, Sung FC, Yang CY, Chien KL, Chen WJ, et al. Chin-Shan community cardiovascular cohort in Taiwan: baseline data and 5-year follow-up morbidity and mortality. J. Clin. Epidemiol. 2000;53:836–846
  13. Andersen L, Dinesen B, Jorgensen PN, Poulser F, Roder ME. Enzyme immunoassay for intact human insulin in serum or plasma. Clin. Chem. 1993;39:578–582
  14. Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III). JAMA. 2001;285:2486–2497
  15. Tan CE, Ma S, Wai D, Chew SK, Tai ES. Can we apply the National Cholesterol Education Program Adult Treatment Panel definition of the metabolic syndrome to Asians?. Diabetes Care. 2004;27:1182–1186
  16. Cook S, Weitzman M, Auinger P, Nguyen M, Dietz WH. Prevalence of a metabolic syndrome phenotype in adolescents: findings from the third National Health and Nutrition Examination Survey, 1988–1994. Arch. Pediatr. Adolesc. Med. 2003;157:821–827
  17. S.A.G.E., Statistical analysis for genetic epidemiology, Release 3.1. Computer program package available from the Department of Epidemiology and Biostatistics, Rammelkamp Center for Education and Research, MetroHealth Campus, Case Western Reserve University, Cleveland, 1997.
  18. Almasy L, Blangero J. Multipoint quantitative-trait linkage analysis in general pedigrees. Am. J. Hum. Genet. 1998;62:1198–1211
  19. Liang KY, Zeger SL. Regression analysis for correlated data. Annu. Rev. Public. Health. 1993;14:43–68
  20. Francke S, Manraj M, Lacquemant C, Lecoeur C, Lepretre F, Passa P, et al. A genome-wide scan for coronary heart disease suggests in Indo-Mauritians a susceptibility locus on chromosome 16p13 and replicates linkage with the metabolic syndrome on 3q27. Hum. Mol. Genet. 2001;10:2751–2765
  21. Langefeld CD, Wagenknecht LE, Rotter JI, Williams AH, Hokanson JE, Saad MF, et al. Linkage of the metabolic syndrome to 1q23–q31 in Hispanic families: the insulin resistance atherosclerosis study family study. Diabetes. 2004;53:1170–1174
  22. Loos RJ, Katzmarzyk PT, Rao DC, Rice T, Leon AS, Skinner JS, et al. Genome-wide linkage scan for the metabolic syndrome in the HERITAGE family study. J. Clin. Endocrinol. Metab. 2003;88:5935–5943
  23. Kissebah AH, Sonnenberg GE, Myklebust J, Goldstein M, Broman K, James RG, et al. Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome. Proc. Natl. Acad. Sci. U.S.A. 2000;1997:14478–14483
  24. Ng MC, So WY, Lam VK, Cockram CS, Bell GI, Cox NJ, et al. Genome-wide scan for metabolic syndrome and related quantitative traits in Hong Kong Chinese and confirmation of a susceptibility locus on chromosomes1q21–25. Diabetes. 2004;53:2676–2683
  25. Xiang K, Wang Y, Zheng T, Jia W, Li J, Chen L, et al. Genome-wide search for type 2 diabetes/impaired glucose homeostasis susceptibility genes in the Chinese: significant linkage to chromosome 6q21–q23 and chromosome 1q21–q24. Diabetes. 2004;53:228–234
  26. Lacquemant C, Froguel P, Lobbens S, Izzo P, Dina C, Ruiz J. The adiponectin gene SNP+45 is associated with coronary artery disease in Type 2 (non-insulin-dependent) diabetes mellitus. Diabetes Med. 2004;21:776–781
  27. Martin S, Nicaud V, Humphries SE, Talmud PJ. Contribution of APOA5 gene variants to plasma triglyceride determination and to the response to both fat and glucose tolerance challenges. Biochim. Biophys. Acta. 2003;1637:217–225
  28. Yang WS, Hsiung CA, Ho LT, Chen YT, He CT, Curb JD, et al. Genetic epistasis of adiponectin and PPARgamma2 genotypes in modulation of insulin sensitivity: a family-based association study. Diabetologia. 2003;46:977–983
  29. Sanchez-Corona J, Flores-Martinez SE, Machorro-Lazo MV, Galaviz-Hernandez C, Moran-Moguel MC, Perea FJ, et al. Polymorphisms in candidate genes for type 2 diabetes mellitus in a Mexican population with metabolic syndrome findings. Diabetes Res. Clin. Pract. 2004;63:47–55
  30. Wang H, Zhang H, Jia Y, Zhang Z, Craig R, Wang X, et al. Adiponectin receptor 1 gene (ADIPOR1) as a candidate for type 2 diabetes and insulin resistance. Diabetes. 2004;53:2132–2136
  31. Reddy KS. Cardiovascular disease in non-Western countries. N. Engl. J. Med. 2004;350:2438–2440
  32. He J, Gu D, Reynolds K, Wu X, Muntner P, Zhao J, et al. Serum total and lipoprotein cholesterol levels and awareness, treatment, and control of hypercholesterolemia in China. Circulation. 2004;110:405–411

PII: S0168-8227(06)00432-3

doi: 10.1016/j.diabres.2006.09.026

Diabetes Research and Clinical Practice
Volume 76, Issue 3 , Pages 418-424 , June 2007