Diabetes Research and Clinical Practice
Volume 76, Issue 3 , Pages 397-403 , June 2007

Insulin secretion and insulin resistance in newly diagnosed, drug naive prediabetes and type 2 diabetes patients with/without metabolic syndrome

  • Sang Youl Rhee

      Affiliations

    • Department of Endocrinology and Metabolism, College of Medicine, Kyung Hee University, Seoul, Republic of Korea
    • Research Institute of Endocrinology, College of Medicine, Kyung Hee University, Seoul, Republic of Korea
    • ,
  • Suk Chon

      Affiliations

    • Department of Endocrinology and Metabolism, College of Medicine, Kyung Hee University, Seoul, Republic of Korea
    • Research Institute of Endocrinology, College of Medicine, Kyung Hee University, Seoul, Republic of Korea
    • ,
  • Seungjoon Oh

      Affiliations

    • Department of Endocrinology and Metabolism, College of Medicine, Kyung Hee University, Seoul, Republic of Korea
    • Research Institute of Endocrinology, College of Medicine, Kyung Hee University, Seoul, Republic of Korea
    • ,
  • Sung Woon Kim

      Affiliations

    • Department of Endocrinology and Metabolism, College of Medicine, Kyung Hee University, Seoul, Republic of Korea
    • Research Institute of Endocrinology, College of Medicine, Kyung Hee University, Seoul, Republic of Korea
    • ,
  • Jin-Woo Kim

      Affiliations

    • Department of Endocrinology and Metabolism, College of Medicine, Kyung Hee University, Seoul, Republic of Korea
    • Research Institute of Endocrinology, College of Medicine, Kyung Hee University, Seoul, Republic of Korea
    • ,
  • Young Seol Kim

      Affiliations

    • Department of Endocrinology and Metabolism, College of Medicine, Kyung Hee University, Seoul, Republic of Korea
    • Research Institute of Endocrinology, College of Medicine, Kyung Hee University, Seoul, Republic of Korea
    • ,
  • Jeong-taek Woo

      Affiliations

    • Department of Endocrinology and Metabolism, College of Medicine, Kyung Hee University, Seoul, Republic of Korea
    • Research Institute of Endocrinology, College of Medicine, Kyung Hee University, Seoul, Republic of Korea
    • Corresponding Author InformationCorresponding author at: Department of Endocrinology and Metabolism, College of Medicine, Kyung Hee University, #1 Hoegi-dong, Dongdaemoon-ku, Seoul, Republic of Korea. Tel.: +82 2 958 8199/8200/8128; fax: +82 2 968 1848.

Received 6 June 2006 ,Accepted 19 September 2006.

References 

  1. DeFronzo RA. Pathogenesis of type 2 diabetes mellitus. Med. Clin. North. Am. 2004;88:787–835IX
  2. Kahn SE. Clinical review 135: the importance of beta-cell failure in the development and progression of type 2 diabetes. J. Clin. Endocrinol. Metab. 2001;86:4047–4058
  3. Leahy JL. Natural history of beta-cell dysfunction in NIDDM. Diabetes Care. 1990;13:992–1010
  4. Weyer C, Bogardus C, Mott DM, Pratley RE. The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J. Clin. Invest. 1999;104:787–794
  5. Hawkins M, Rossetti L. Insulin Resistance and Its Role in the Pathogenesis of Type 2 Diabetes. Lippincott Willians & Wilkins; 2005;
  6. Folsom AR, Kushi LH, Anderson KE, Mink PJ, Olson JE, Hong DP, et al. Associations of general and abdominal obesity with multiple health outcomes in older women: the Iowa Women's Health Study. Arch. Intern. Med. 2000;160:2117–2128
  7. Calle EE, Thun MJ, Petrelli JM, Rodriguez C, Heath CW. Body-mass index and mortality in a prospective cohort of U.S. adults. N. Engl. J. Med. 1999;341:1097–1105
  8. Lillioja S, Mott DM, Spraul M, Ferraro R, Foley JE, Ravussin E, et al. Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians. N. Engl. J. Med. 1993;329:1988–1992
  9. Martin BC, Warram JH, Krolewski AS, Bergman RN, Soeldner JS, Kahn CR. Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study. Lancet. 1992;340:925–929
  10. Meigs JB. Invited commentary: insulin resistance syndrome? Syndrome X? Multiple metabolic syndrome? A syndrome at all? Factor analysis reveals patterns in the fabric of correlated metabolic risk factors. Am. J. Epidemiol. 2000;152:908–911
  11. Executive summary of the third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III), JAMA 285 (2001) 2486–2497.
  12. Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA. 2002;287:356–359
  13. Tripathy D, Carlsson N, Almgren P, Isomaa B, Taskinen MR, Tuomi T, et al. Insulin secretion and insulin sensitivity in relation to glucose tolerance: lessons from the Botnia Study. Diabetes. 2000;49:975–980
  14. Diagnosis and classification of diabetes mellitus . Diabetes Care. 2004;27(Suppl. 1):S5–S10
  15. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–419
  16. The IDF consensus worldwide definition of the metabolic syndrome [article online], 2005, Available from http://www.idf.org/webdata/docs/IDF_Metasyndrome_definition.pdf
  17. Lee WY, Park JS, Noh SY, Rhee EJ, Kim SW, Zimmet PZ. Prevalence of the metabolic syndrome among 40,698 Korean metropolitan subjects. Diab. Res. Clin. Pract. 2004;65:143–149
  18. Yeckel CW, Taksali SE, Dziura J, Weiss R, Burgert TS, Sherwin RS, et al. The normal glucose tolerance continuum in obese youth: evidence for impairment in beta-cell function independent of insulin resistance. J. Clin. Endocrinol. Metab. 2005;90:747–754

PII: S0168-8227(06)00428-1

doi: 10.1016/j.diabres.2006.09.035

Diabetes Research and Clinical Practice
Volume 76, Issue 3 , Pages 397-403 , June 2007

Article Tools

* Image Usage & Resolution