Childhood obesity and its relation to serum adiponectin and leptin: A report from a population-based study

Nishimura, Rimei; Sano, Hironari; Matsudaira, Toru; Miyashita, Yumi; Morimoto, Aya; Shirasawa, Takako; Takahashi, Eiko; Kawaguchi, Takeshi; Tajima, Naoko

doi:10.1016/j.diabres.2006.09.023

« Previous Next »Diabetes Research and Clinical Practice
Volume 76, Issue 2 , Pages 245-250, May 2007

Childhood obesity and its relation to serum adiponectin and leptin: A report from a population-based study

Rimei Nishimura
- Division of Diabetes, Endocrinology and Metabolism, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
- Graduate School of Public Health, University of Pittsburgh, Pittsburgh, USA
- Corresponding author.
Hironari Sano
- Division of Diabetes, Endocrinology and Metabolism, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
Toru Matsudaira
- Division of Diabetes, Endocrinology and Metabolism, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
Yumi Miyashita
- Division of Diabetes, Endocrinology and Metabolism, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
Aya Morimoto
- Division of Diabetes, Endocrinology and Metabolism, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
Takako Shirasawa
- Department of Public Health, Showa University School of Medicine, Tokyo, Japan
Eiko Takahashi
- Department of Public Health, Showa University School of Medicine, Tokyo, Japan
Takeshi Kawaguchi
- Department of Public Health, Showa University School of Medicine, Tokyo, Japan
Naoko Tajima
- Division of Diabetes, Endocrinology and Metabolism, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan

Received 6 March 2006; received in revised form 16 August 2006; accepted 1 September 2006. published online 24 November 2006.

Abstract

This study examined the relationships between serum adiponectin (AD) and leptin (LP) levels, and obesity using a population-based cohort consisted of 315 (9–10 year olds: G1) and 308 (12–13 year olds: G2) school children. Serum AD, LP and other markers were compared according to the presence of obesity.

The prevalence rates of obesity were 14.9% in G1 and 9.4% in G2. The medians of serum AD (μg/dl: non-obese/obese) were statistically lower in obese children (9.6/8.3 in G1, p<0.05; 8.9/6.6 in G2, p<0.05), and the medians of serum LP (ng/dl) were statistically higher in obese children (3.7/12.5 in G1, p<0.05; 2.9/8.4 in G2, p<0.05). The serum LP levels were significantly positively correlated with percent overweight (POW) irrespective of age and sex, and the serum AD levels were significantly negatively correlated with POW except for boys in G1. Multivariate regression analyses revealed that LP, LDL-cholesterol and gender in G1, and LP, AD, blood pressure and gender in G2 were significantly correlated with POW.

A large-scale, population-based study revealed that AD was lower and LP higher in obese children, and that the obese status in G2 was related to a worse metabolic profile than the case in G1.

Keywords: Children, Obesity, Leptin, Adiponectin