Diabetes Research and Clinical Practice
Volume 76, Issue 3 , Pages 351-357 , June 2007

Elevated serum acylated (biologically active) ghrelin and resistin levels associate with pregnancy-induced weight gain and insulin resistance

  • Eva Palik

      Affiliations

    • 3rd Department of Medicine, Semmelweis University, H-1125 Kútvölgyi u 4, Budapest, Hungary
    • Corresponding Author InformationCorresponding author. Tel.: +36 1 3251100; fax: +36 1 3751173.
    • ,
  • Eva Baranyi

      Affiliations

    • Diabetes Outpatient Unit, National Medical Center, Budapest, Hungary
    • ,
  • Zsolt Melczer

      Affiliations

    • 2nd Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary
    • ,
  • Maria Audikovszky

      Affiliations

    • 4th Department of Medicine, St. Imre Hospital, Budapest, Hungary
    • ,
  • Albert Szöcs

      Affiliations

    • 1st Department of Medicine, Károlyi Hospital, Budapest, Hungary
    • ,
  • Gábor Winkler

      Affiliations

    • 2nd Department of Medicine, St. John's Hospital, Budapest, Hungary
    • ,
  • Károly Cseh

      Affiliations

    • 1st Department of Medicine, Károlyi Hospital, Budapest, Hungary

Received 4 January 2006 ,Accepted 4 September 2006.

References 

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  2. Cseh K, Baranyi É, Melczer Zs, Csákány GM, Kovács M, Gerő G, et al. The pathophysiological influence of leptin and tumor necrosis factor system on maternal insulin resistance: negative correlations with anthropometric parameters of neonates in gestational diabetes. Gynecol. Endocrinol. 2002;16:453–460
  3. Cseh K, Baranyi É, Melczer Zs, Kaszás E, Winkler G. Plasma adiponectin and pregnancy-induced insulin resistance. Diabetes Care. 2004;27:274–275
  4. Volante M, Allia E, Gugliotta P, Funaro A, Broglio F, Denghenghi R, et al. Expression of ghrelin and GHS receptor by pancreatic islet cells and related endocrine tumors. J. Clin. Endocrinol. Metab. 2002;87:1300–1308
  5. Korbonits M, Bustin SA, Kojima M, Jordan S, Adams EF, Lowe DG, et al. The expression of the growth hormone secretagogue ligand, ghrelin in normal and abnormal human pituitary and other neuroendocrine tissues. J. Clin. Endocrinol. Metab. 2001;86:881–887
  6. Vang G, Lee H-M, Englander E, Greeley GH. Ghrelin—not just an other stomach hormone. Regul. Pept. 2002;105:75–81
  7. De Ambrogi M, Volpe S, Tamanini T. Ghrelin: central and peripheral effects of a novel peptidyl homone. Med. Sci. Monit. 2003;9:RA217–RA224
  8. Korbonits M, Goldstone AP, Gueorguiev M, Grossman AB. Ghrelin—a hormone with multiple functions. Front. Neuroendocrinol. 2004;25:27–68
  9. Steppan CM, Lazar MA. Resistin and obesity associated insulin resistance. Trends Endocrinol. Metab. 2002;13:18–22
  10. Adeghate E. An update on the biology and physiology of resistin. Cell. Mol. Life. Sci. 2004;61:2485–2496
  11. Lehrke M, Reilly NP, Millington SC, Iqbal N, Rader DJ, Lazar MA. An inflammatory cascade leading to hyperresistinemia in humans. PLOS Med. 2004;1:161–168
  12. Berg AH, Combs TP, Scherer PE. ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism. Trends Endocrinol. Metab. 2002;13:84–89
  13. World Health Organization, Definition, diagnosis and classification of diabetes mellitus and its complications, Report of a WHO consultation, Part I: Diagnosis and classification of diabetes mellitus, WHO, Geneva, 1999.
  14. Lee WG, Gavrila D, Liu X, Wang L, Gunnlaugsson S, Stoll LL, et al. Ghrelin inhibits proinflammatory responses and nuclear factor-κB activation in human endothelial cells. Circulation. 2004;109:2221–2226
  15. Dixit VD, Schaffer EM, Pyle RS, Collins GD, Sakthivel SK, Palaniappan R, et al. Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression in human monocytes and T-cells. J. Clin. Invest. 2004;114:57–66
  16. Asakawa A, Inui A, Kaga T, Katsuura J, Fujimya M, Fujino MA, et al. Antagonism of ghrelin receptor reduces food intake and body weight gain in mice. Gout. 2003;52:947–952
  17. Watmore AJ, Hall CN, Jones J, Westwood M, Clayton PE. Ghrelin concentration in healthy children and adolescents. Clin. Endocrinol. (Oxf). 2003;59:649–654
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  19. Fuglsang J, Skjaerbaek C, Espelund U, Frystys J, Fisker S, Flyvbjerg A, et al. Ghrelin and its relationship to growth hormones during normal pregnancy. Clin. Endocrinol. (Oxf). 2005;62:554–559
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  21. Xu H, Barnes GT, Yang Q, Tan G, Yang B, Chou CJ, et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J. Clin. Invest. 2003;112:1821–1830
  22. Lappas M, Yee K, Permezel M, Rice GE. Release and regulation of leptin, resistin and adiponectin from human placenta, fetal membranes, and maternal adipose tissue and skeletal muscle from normal and gestational diabetes mellitus-complicated pregnancies. J. Endocrinol. 2005;186:457–465

PII: S0168-8227(06)00388-3

doi: 10.1016/j.diabres.2006.09.005

Diabetes Research and Clinical Practice
Volume 76, Issue 3 , Pages 351-357 , June 2007

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