Transforming growth factor-beta 1 levels in women with prior history of gestational diabetes mellitus

Yener, S.; Demir, T.; Akinci, B.; Bayraktar, F.; Kebapcilar, L.; Ozcan, M.A.; Biberoglu, S.; Yesil, S.

doi:10.1016/j.diabres.2006.08.014

« Previous Next »Diabetes Research and Clinical Practice
Volume 76, Issue 2 , Pages 193-198, May 2007

Transforming growth factor-beta 1 levels in women with prior history of gestational diabetes mellitus

S. Yener
- Dokuz Eylul University, School of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism, Izmir, Turkey
- Corresponding author. Tel.: +90 2324123716; fax: +90 2322594898
T. Demir
- Dokuz Eylul University, School of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism, Izmir, Turkey
B. Akinci
- Dokuz Eylul University, School of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism, Izmir, Turkey
F. Bayraktar
- Dokuz Eylul University, School of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism, Izmir, Turkey
L. Kebapcilar
- Dokuz Eylul University, School of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism, Izmir, Turkey
M.A. Ozcan
- Dokuz Eylul University, School of Medicine, Department of Internal Medicine, Division of Hematology, Izmir, Turkey
S. Biberoglu
- Dokuz Eylul University, School of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism, Izmir, Turkey
S. Yesil
- Dokuz Eylul University, School of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism, Izmir, Turkey

Received 14 July 2006; received in revised form 24 August 2006; accepted 29 August 2006. published online 04 October 2006.

Abstract

It is known that women with prior history of gestational diabetes mellitus (pGDM) feature obesity, insulin resistance and endothelial dysfunction which cause premature atherosclerosis. Transforming growth factor-beta 1 (TGF-β1) is a key cytokine in obesity and insulin resistance and also play important roles in the development of atherosclerosis. This study was conducted to demonstrate the serum TGF-β1 levels of people with pGDM. Thirty women with pGDM, 20 women with type 2 diabetes mellitus (T2DM) and 20 healthy women were enrolled. Serum TGF-β1 levels of people with pGDM were found to be significantly higher than healthy controls and significantly lower than women with T2DM. TGF-β1 levels were found to be correlated with postprandial glucose and age and inversely correlated with body mass index (BMI) and waist circumference. On multiple regression analysis postprandial glucose level, age and BMI were determined as the most important factors affecting TGF-β1 levels. This sudy demonstrates elevated TGF-β1 levels in pGDM. The inflammatory response to hyperglycemia and insulin resistance could be the major factors for the increased expression of TGF-β1.

Keywords: Transforming growth factor-beta 1, Previous gestational diabetes mellitus