Diabetes Research and Clinical Practice
Volume 75, Issue 3 , Pages 320-326 , March 2007

Hepatitis C, metabolic syndrome, and inflammatory markers: Results from the Third National Health and Nutrition Examination Survey [NHANES III]

  • Magda Shaheen

      Affiliations

    • Department of Internal Medicine, Charles R. Drew University of Medicine and Science, 12021 South Wilmington Avenue Los Angeles, CA 90059, United States
    • Corresponding Author InformationCorresponding author. Tel.: +1 310 761 4727; fax: +1 310 631 1495.
    • ,
  • Diana Echeverry

      Affiliations

    • Department of Internal Medicine, Charles R. Drew University of Medicine and Science, 12021 South Wilmington Avenue Los Angeles, CA 90059, United States
    • ,
  • Marcela Garcia Oblad

      Affiliations

    • Department of Internal Medicine, Charles R. Drew University of Medicine and Science, 12021 South Wilmington Avenue Los Angeles, CA 90059, United States
    • ,
  • Marie I. Montoya

      Affiliations

    • Department of Internal Medicine, Charles R. Drew University of Medicine and Science, 12021 South Wilmington Avenue Los Angeles, CA 90059, United States
    • ,
  • Senait Teklehaimanot

      Affiliations

    • Department of Family Medicine, Charles R. Drew University of Medicine and Science, 12021 South Wilmington Avenue Los Angeles, CA 90059, United States
    • ,
  • Abbasi J. Akhtar

      Affiliations

    • Department of Internal Medicine, Charles R. Drew University of Medicine and Science, 12021 South Wilmington Avenue Los Angeles, CA 90059, United States

Received 11 February 2006 ,Accepted 11 July 2006.

References 

  1. Albright E, Bell D. The liver, liver disease, and diabetes mellitus. The Endocrinologist. 2003;13(1):58–66
  2. Lauer G, Bruce D. Hepatitis C virus infection. New Engl. J. Med. 2001;345(1):41–52
  3. Allison M, Palmer C, Alexander G. Evidence for a link between hepatitis C infection and diabetes mellitus in a cirrhotic population. J. Hepatol. 1994;21:1135–1139
  4. Virseda I, Jaqueti J, Nicolas M, Prieto R, Somoza M, Navarro F. Hepatitis C virus and type-2 diabetes mellitus. Is there a connection?. Enferm. Infecc. Microbiol. Clin. 2002;20(2):96–97
  5. Thuluvath P, John P. Association between hepatitis C, diabetes mellitus, and race. Am. J. Gastroenterol. 2003;98(2):438–441
  6. Soma J, Taguma Y, Chiba S, Sato H, Sugimura K, Ogawa S, et al. High prevalence and adverse effect of hepatitis C virus infection in type II diabetic-related nephropathy. J. Am. Soc. Nephrol. 2000;11(4):690–699
  7. Sangiorgio L, Attardo T, Gangemi R, Rubino C, Barone M, Lunetta M. Increased frequency of HCV and HBV infection in type 2 diabetic patients. Diabetes Res. Clin. Pract. 2000;48(2):147–151
  8. Qureshi H, Ahsan T, Mujeeb S, Jawad F, Mehdi I, Ahmed W, et al. Diabetes mellitus is equally frequent in chronic HCV and HBV infection. J. Pak. Med. Assoc. 2002;52(7):280–283
  9. Mehta S, Brancati F, Sulkowski M, Strathdee S, Szklo M, Thomas D. Prevalence of type 2 diabetes mellitus among persons with hepatitis C virus infection in the United States, letter to the editor. Hepatology. 2001;33(6):1554
  10. Mehta S, Brancati F, Strathdee S, Pankow J, Netski D, Coresh J, et al. Hepatitis C virus infection and incident type 2 diabetes. Hepatology. 2003;38(1):50–56
  11. Caronia S, Taylor SK, Pagliaro L, Carr C, Palazzo U, Petrik J, et al. Further evidence for an association between non-insulin-dependent diabetes mellitus and chronic hepatitis C virus infection. Hepatology. 1999;30(4):1059–1063
  12. Mason J, Lau N, Hoang K, Qian G, Alexander L, Xu L, et al. Association of diabetes mellitus and chronic hepatitis C virus infection. Hepatology. 1999;29(2):328–333
  13. Strassburg C, Obermayer-Straub P, Manns M. Autoimmunity in hepatitis C and D virus infection. J. Viral. Hepat. 1996;3(2):49–59
  14. Ramji A, Yoshida E. Diabetes mellitus after liver transplantation: another extrahepatic manifestation of hepatitis C. Can. J. Gastroenterol. 2001;15(7):432
  15. Mitchell R, Cotran R. Acute and chronic inflammation. In:  Kumar CR,  Robbins SL editor. Robbins Basic Pathology. Philadelphia: Elsevier Science; 2003;p. 33–59
  16. Maeno T, Okumura A, Ishikawa T, Kato K, Sakakibara F, Sato K, et al. Mechanisms of increased insulin resistance in non-cirrhotic patients with chronic hepatitis C virus infection. J. Gastroenterol. Hepatol. 2003;18(12):1358–1363
  17. Yudkin J, Stehouwer C, Emeis J, Coppack S. C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue?. Arterioscler. Thromb. Vasc. Biol. 1999;19(4):972–978
  18. Hotamisligil G, Peraldi P, Budavari A, Ellis R, White M, Spiegelman B. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science. 1996;271(5249):665–668
  19. Hui J, Sud A, Farrell G, Bandara P, Byth K, Kench J, et al. Insulin resistance is associated with chronic hepatitis C virus infection and fibrosis progression. Gastroenterology. 2003;125:1695–1704
  20. Park Y, Zhu S, Palaniappan L, Heshka S, Carnethon M, Heymsfield S. The metabolic syndrome: prevalence and associated risk factor findings in the US population from the Third National Health and Nutrition Examination Survey, 1988–1994. Arch. Inter. Med. 2003;163(4):427–436
  21. Martin-Lazaro J, Becerra-Fernandez A. The metabolic syndrome: uncertain criteria. Pharmacol. Res. 2005;51(4):387–389
  22. National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Final Report, Circulation, 106 (25) (2002) 3143–31421.
  23. Ford E, Giles H, Mokdad A. Increasing prevalence of the metabolic syndrome among U.S. adults. Diabetes Care. 2004;27(10):2444–2449
  24. Ford E. The metabolic syndrome and C-reactive protein, fibrinogen, and leukocyte count: findings from the Third National Health and Nutrition Examination Survey. Atherosclerosis. 2003;168:351–358
  25. Jehn M, Clark J, Guallar E. Serum ferritin and risk of the metabolic syndrome in U.S. adults. Diabetes Care. 2004;27:2422–2428
  26. Centers for Disease Control and Prevention, The Third National Health and Nutrition Examination Survey (NHANES III 1988–1994) (1996).
  27. Liangpunsakul S, Naga C. Relationship between hepatitis C and microalbuminuria: results from the NHANES III. Kidney Int. 2005;67:285–290
  28. Ford E, Giles W, Dietz W. Prevalence of the metabolic syndrome among US adults. JAMA. 2002;287(3):356–359
  29. Maeno T, Ishikawa T, Kato K, Sakakibara F, Sato K, Ayada M, et al. Mechanisms of increased insulin resistance in non-cirrhotic patients with chronic hepatitis C virus infection. J. Gastroenterol. Hepatol. 2003;18:1358–1363
  30. Snehalatha C, Viswanathan V, Ramachandran A. Cutoff values for normal anthropometric variables in Asian Indian adults. Diabetes Care. 2003;26:1380–1384
  31. Fernandez-Real J, Ricart-Engel W, Arroyo E, et al. Serum ferritin as a component of the insulin resistance syndrome. Diabetes Care. 1998;21:62–68
  32. Chen J, Wildman R, Hamm L, et al. Association between inflammation and insulin resistance in U.S. non-diabetic adults: results from the Third National Health and Nutrition Examination Survey. Diabetes Care. 2004;27:2960–2965

☆ This work was supported in part by G12-RR03026-19, P20-RR11145, U54 RR019234, U54 RR14616 NIH/NCRR and P20MD000182-02 from the NIH/NCMHD.

PII: S0168-8227(06)00308-1

doi: 10.1016/j.diabres.2006.07.008

Diabetes Research and Clinical Practice
Volume 75, Issue 3 , Pages 320-326 , March 2007

Article Tools