Diabetes Research and Clinical Practice
Volume 75, Issue 3 , Pages 292-300 , March 2007

Monocyte-derived macrophages from men and women with Type 2 diabetes mellitus differ in fatty acid composition compared with non-diabetic controls

  • Saranga Senanayake

      Affiliations

    • School of Medicine and Pharmacology, University of Western Australia, Fremantle and Royal Perth Hospitals, Western Australia, Australia
  • ,
  • Leon M. Brownrigg

      Affiliations

    • School of Medicine and Pharmacology, University of Western Australia, Fremantle and Royal Perth Hospitals, Western Australia, Australia
  • ,
  • Vijay Panicker

      Affiliations

    • Department of Endocrinology and Diabetes, Fremantle Hospital, Western Australia, Australia
  • ,
  • Kevin D. Croft

      Affiliations

    • School of Medicine and Pharmacology, University of Western Australia, Fremantle and Royal Perth Hospitals, Western Australia, Australia
  • ,
  • David A. Joyce

      Affiliations

    • School of Medicine and Pharmacology, University of Western Australia, Fremantle and Royal Perth Hospitals, Western Australia, Australia
  • ,
  • James H. Steer

      Affiliations

    • School of Medicine and Pharmacology, University of Western Australia, Fremantle and Royal Perth Hospitals, Western Australia, Australia
  • ,
  • Ian B. Puddey

      Affiliations

    • School of Medicine and Pharmacology, University of Western Australia, Fremantle and Royal Perth Hospitals, Western Australia, Australia
  • ,
  • Bu B. Yeap

      Affiliations

    • School of Medicine and Pharmacology, University of Western Australia, Fremantle and Royal Perth Hospitals, Western Australia, Australia
    • Department of Endocrinology and Diabetes, Fremantle Hospital, Western Australia, Australia
    • Corresponding Author InformationCorresponding author at: School of Medicine and Pharmacology, Level 2, T-Block, Fremantle Hospital, Alma Street, Fremantle, Western Australia 6160, Australia. Tel.: +61 8 9431 3229; fax: +61 8 9431 2977.

Received 8 June 2006 ,Accepted 10 July 2006.

References 

  1. Adler AI. Managing diabetes: what to do about cardiovascular disease. Diab. Res. Clin. Pract. 2003;61:S3–S8
  2. Carmena R. Type 2 diabetes, dyslipidemia, and vascular risk: Rationale and evidence for correcting the lipid imbalance. Am. Heart J. 2005;150:859–870
  3. Osterud B, Bjorklid E. Role of monocytes in atherogenesis. Physiol. Rev. 2003;83:1069–1112
  4. Duffy D, Rader DJ. Emerging therapies targeting high-density lipoprotein metabolism and reverse cholesterol transport. Circulation. 2006;113:1140–1150
  5. Berger JP, Akiyama TE, Meinke PT. PPARs: therapeutic targets for metabolic disease. TRENDS Pharmacol. Sci. 2005;26:244–251
  6. Li AC, Palinski W. Peroxisome proliferator-activated receptors: how their effects on macrophages can lead to the development of a new drug therapy against atherosclerosis. Annu. Rev. Pharmacol. Toxicol. 2006;46:1–39
  7. Chinetti G, Lestavel S, Fruchart J-C, Clavey V, Staels B. Peroxisome proliferator-activated receptor α reduces cholesterol esterification in macrophages. Circ. Res. 2003;92:212–217
  8. Chinetti G, Lestavel S, Bocher V, Remaley AT, Neve B, Torra IP, et al. PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway. Nat. Med. 2001;7:53–58
  9. Gbaguidi FG, Chinetti G, Milosavljevic D, Teissier E, Chapman J, Olivecrona G, et al. Peroxisome proliferator-activated receptor (PPAR) agonists decrease lipoprotein lipase secretion and glycated LDL uptake by human macrophages. FEBS Lett. 2002;512:85–90
  10. Chawla A, Boisvert WA, Lee CH, Laffitte BA, Barak Y, Joseph SB, et al. A PPARγ-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis. Mol. Cell. 2001;7:161–171
  11. Akiyama TE, Sakai S, Lambert G, Nicol CJ, Matsusue K, Pimprale S, et al. Conditional disruption of the peroxisome proliferator-activated receptor γ gene in mice results in lowered expression of ABCA1, ABCG1, and ApoE in macrophages and reduced cholesterol efflux. Mol. Cell. Biol. 2002;22:2607–2619
  12. Argmann CA, Sawyez CJ, McNeil RA, Hegele RA, Huff MW. Activation of peroxisome proliferator-activated receptor γ and retinoid X receptor results in net depletion of cellular cholesterol esters in macrophages exposed to oxidised lipoproteins. Arterioscler. Thromb. Vasc. Biol. 2003;23:475–482
  13. Hirakata M, Tozawa R, Imura Y, Sugiyama Y. Comparison of the effects of pioglitazone and rosiglitazone on macrophage foam cell formation. Biochem. Biophys. Res. Commun. 2004;323:782–788
  14. Llaverias G, Lacasa D, Vinals M, Vazquez-Carrera M, Sanchez RM, Laguna JC, et al. Reduction of intracellular cholesterol accumulation in THP-1 macrophages by a combination of rosiglitazone and atorvastatin. Biochem. Pharmacol. 2004;68:155–163
  15. Wang Y, Oram JF. Unsaturated fatty acids inhibit cholesterol efflux from macrophages by increasing degradation of ATP-binding cassette transporter A1. J. Biol. Chem. 2002;277:5692–5697
  16. Sun Y, Hao M, Luo Y, Liang CP, Silver DL, Cheng C, et al. Stearoyl-CoA desaturase inhibits ATP-binding cassette transporter A1-mediated cholesterol efflux and modulates membrane domain structure. J. Biol. Chem. 2003;278:5813–5820
  17. Wang Y, Kurdi-Haidar B, Oram JF. LXR-mediated activation of macrophage stearoyl-Co A desaturase generates unsaturated fatty acids that destabilise ABCA1. J. Lipid Res. 2004;45:972–980
  18. Wang Y, Oram JF. Unsaturated fatty acids phosphorylate and destabilize ABCA1 through a phospholipase D2 pathway. J. Biol. Chem. 2005;280:35896–35903
  19. Hodge A, Patterson AJ, Brown WJ, Ireland P, Giles G. The Anti Cancer Council of Victoria FFQ; relative validity of nutrient intakes compared with weighed food records in young to middle aged women in a study of iron supplementation. Aust. NZ Public Health. 2000;24:576–583
  20. Chinetti G, Griglio S, Antonucci M, Torra IP, Delerive P, Majd Z, et al. Activation of proliferator-activated receptors α and γ induces apoptosis of human monocyte-derived macrophages. J. Biol. Chem. 1998;273:25573–25580
  21. Holness CL, Simmons DL. Molecular cloning of CD68, a human macrophage marker related to lysosomal glycoproteins. Blood. 1993;81:1607–1613
  22. Waddington E, Sienuarine K, Puddey I, Croft K. Identification and quantitation of unique fatty acid oxidation products in human atherosclerotic plaque using high-performance liquid chromatographym. Anal. Biochem. 2001;292:234–244
  23. Yamato K, Tamasawa N, Murakami H, Matsui J, Tanabe J, Suda T, et al. Evaluation of apolipoprotein E secretion by macrophages in Type 2 diabetic patients: role of HDL and apolipoprotein A-1. Diab. Res. Clin. Pract. 2005;69:124–128
  24. Kavanagh IC, Symes CE, Renaudin P, Nova E, Mesa MD, Boukouvalas G, et al. Degree of oxidation of low density lipoprotein affects expression of CD36 and PPARγ, but not cytokine production, by human monocyte-macrophages. Atherosclerosis. 2003;168:271–282
  25. Carpenter KLH, Callis IR, Arends MJ. Mildly oxidised LDL induces more macrophage death than moderately oxidised LDL: roles of peroxidation, lipoprotein-associated phospholipase A2 and PPARγ. FEBS Lett. 2003;553:145–150
  26. Sartippour MR, Renier G. Differential regulation of macrophage peroxisome proliferator-activated receptor expression by glucose. Atheroscler. Thromb. Vasc. Biol. 2000;20:104–110
  27. Miyazaki M, Ntambi JM. Role of stearoyl-coenzyme A desaturase in lipid metabolism. Prostaglandins Leukot. Essent. Fatty Acids. 2003;68:113–121
  28. Nakamura MT, Nara TY. Structure, function and dietary regulation of Δ6, Δ5, and Δ9 desaturases. Annu. Rev. Nutr. 2004;24:345–376
  29. Kaduce TL, Figard PH, Leifur R, Spector AA. Formation of 9-hydroxyoctadecadienoic acid from linoleic acid in endothelial cells. J. Biol. Chem. 1989;264:6823–6830
  30. Nagy L, Tontonoz P, Alvarez JGA, Chen H, Evans RM. Oxidised LDL regulates macrophage gene expression through ligand activation of PPARγ. Cell. 1998;93:229–240
  31. Shappell SB, Gupta RA, Manning S, Whitehead R, Boeglin WE, Schneider C, et al. 15 S-hydroxyeicosatetraenoic acid activates peroxisome proliferator-activated receptor γ and inhibits proliferation in PC3 prostate cancer cells. Cancer Res. 2001;61:497–503
  32. Rinker KD, Kirkpatrick AP, Ting-Beall HP, Shepherd RD, Levin JD, Irick J, et al. Linoleic acid increases monocyte deformation and adhesion to endothelium. Atherosclerosis. 2004;177:275–285
  33. Burke V, Croft KD, Puddey IB, Cox KL, Beilin LJ, Vandongen R. Effects of alcohol intake on plasma fatty acids assessed independently of diet and smoking habits. Clin. Sci. 1991;81:785–791
  34. Waddington EI, Croft KD, Sienuarine K, Latham B, Puddey IB. Fatty acid oxidation products in human atherosclerotic plaque: an analysis of clinical and histopathological correlates. Atherosclerosis. 2003;167:111–120
  35. Kim Y-C, Gomez FE, Fox BG, Ntambi JM. Differential regulation of the stearoyl-CoA desaturase genes by thiazolidinediones in 3T3-L1 adipocytes. J. Lipid Res. 2000;41:1310–1316

 Part of the data contained in this manuscript was presented at the Annual Scientific Meeting of the Australian Atherosclerosis Society, Darwin, 19–22 October 2005.

PII: S0168-8227(06)00302-0

doi: 10.1016/j.diabres.2006.07.009

Diabetes Research and Clinical Practice
Volume 75, Issue 3 , Pages 292-300 , March 2007