« Previous
Diabetes Research and Clinical Practice
Volume 74, Issue 2,
Supplement
, Pages S63-S69
, 30 November 2006
Therapy targeting β-cell survival and function in type 2 diabetes mellitus
References
- . Lifetime risk for diabetes mellitus in the United States. JAMA. 2003;290:1884–1890
- . The natural history of diabetes-related complications: the UKPDS experience. United Kingdom Prospective Diabetes Study. Diab. Obes. Metab. 1999;1:S7–S13
- . Metabolic and genetic influence on glucose metabolism in type 2 diabetic subjects—experiences from relatives and twin studies. Best Practice Res. Clin. Endocrinol. Metab. 2003;17:445–467
- Heritability estimates for beta cell function and features of the insulin resistance syndrome in UK families with an increased susceptibility to Type 2 diabetes. Diabetologia. 2004;47:732–738
- . Genetic epidemiology of diabetes. J. Clin. Invest. 2005;115:1431–1439
- . Insulin resistance and insulin secretory dysfunction are independent predictors of worsening of glucose tolerance during each stage of Type 2 diabetes development. Diabetes Care. 2001;24:89–94
- Assessment of insulin secretion in relatives of patients with type 2 (non-insulin-dependent) diabetes mellitus: evidence of early beta-cell dysfunction. Metabolism. 2000;49:896–905
- . Diabetes mellitus a “thrifty” genotype rendered detrimental by progress. Am. J. Hum. Genet. 1962;14:352–353
- Endogenous glucose production, insulin sensitivity, and insulin secretion in normal glucose-tolerant Pima Indians with low birth weight. Metabolism. 2004;53:904–911
- Predictors of longitudinal changes in insulin sensitivity and secretion preceding onset of type 2 diabetes. Diabetes. 2005;54:166–174
- . Genetics of Type 2 diabetes. Diab. Med. 2005;22:517–535
- UK prospective diabetes study 16, Overview of 6 years’ therapy of type II diabetes: a progressive disease, Diabetes 44 (1995) 1249–1258.
- . The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J. Clin. Invest. 1999;104:787–794
- . Diminished B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus. J. Clin. Invest. 1984;74:1318–1328
- . Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes. 2003;52:102–110
- . Evaluation of beta-cell secretory capacity using glucagon-like peptide 1. Diabetes Care. 2000;23:807–812
- Exenatide augments first- and second-phase insulin secretion in response to intravenous glucose in subjects with type 2 diabetes. J. Clin. Endocrinol. Metab. 2005;90:5991–5997
- . Diazoxide attenuates glucose-induced defects in first-phase insulin release and pulsatile insulin secretion in human islets. Endocrinology. 2003;144:3399–3405
- Overnight inhibition of insulin secretion restores pulsatility and proinsulin/insulin ratio in type 2 diabetes. Am. J. Physiol. 2000;279:E520–E528
- Glucocorticoid induced insulin resistance impairs basal but not glucose entrained high-frequency insulin pulsatility in humans. Diabetologia. 2002;45:49–55
- . Insulin resistance and insulin secretory dysfunction are independent predictors of worsening of glucose tolerance during each stage of type 2 diabetes development. Diabetes Care. 2001;24:89–94
- . Beta-Cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: a new analysis. J. Clin. Endocrinol. Metab. 2005;90:493–500
- Abnormal patterns of insulin secretion in non-insulin-dependent diabetes mellitus. N. Engl. J. Med. 1988;318:1231–1239
- . Abnormalities in the ultradian oscillations of insulin secretion and glucose levels in type 2 (non-insulin-dependent) diabetic patients. Diabetologia. 1992;35:681–689
- . Impaired pulsatile secretion of insulin in relatives of patients with non-insulin-dependent diabetes. N. Engl. J. Med. 1988;318:1225–1230
- . Loss of early phase of insulin release in humans impairs glucose tolerance and blunts thermic effect of glucose. Diabetes. 1987;36:1167–1172
- . Temporal profiles and clinical significance of pulsatile insulin secretion. Horm. Res. 1998;49:178–184
- . Incretin mimetics and DPP-IV inhibitors for the treatment of type 2 diabetes. Drug Discov. Today. 2005;10:703–710
- Synthetic exendin-4 (exenatide) significantly reduces postprandial and fasting plasma glucose in subjects with type 2 diabetes. J. Clin. Endocrinol. Metab. 2003;88:3082–3089
- . Rosiglitazone short-term monotherapy lowers fasting and post-prandial glucose in patients with type II diabetes. Diabetologia. 2000;43:278–284
- . 24-hour glucose profiles during continuous or oscillatory insulin infusion. Demonstration of the functional significance of ultradian insulin oscillations. J. Clin. Invest. 1995;95:1464–1471
- . Oscillatory insulin secretion: a variable phenotypic marker. Diab. Med. 1996;13:S53–S58
- . Acute insulin responses to intravenous glucose and GLP-1 are independent of preceding high-frequency insulin pulse-defects induced by glucose entrainment in healthy humans. Horm. Metab. Res. 2005;37:40–44
- Beta-cell function and islet morphology in normal, obese, and obese beta-cell mass-reduced Gottingen minipigs. Am. J. Physiol. 2005;288:E412–E421
- . Prevention of diabetes does not completely prevent insulin secretory defects in the ZDF rat. Am. J. Physiol. 1995;269:E786–E792
- . Influence of rosiglitazone treatment on beta-cell function in type 2 diabetes: evidence of an increased ability of glucose to entrain high-frequency insulin pulsatility. J. Clin. Endocrinol. Metab. 2003;88:3794–3800
- . Acute and short-term administration of a sulfonylurea (gliclazide) increases pulsatile insulin secretion in type 2 diabetes. Diabetes. 2001;50:1778–1784
- Repaglinide treatment amplifies first-phase insulin secretion and high-frequency pulsatile insulin release in Type 2 diabetes. Diab. Med. 2005;22:1408–1413
- . Short-term treatment with GLP-1 increases pulsatile insulin secretion in Type II diabetes with no effect on orderliness. Diabetologia. 2000;43:583–588
- Bedtime administration of NN2211, a long-acting GLP-1 derivative, substantially reduces fasting and postprandial glycemia in type 2 diabetes. Diabetes. 2002;51:424–429
- Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretion. J. Biol. Chem. 2001;276:46046–46053
- . Glucokinase, glucose homeostasis, and diabetes mellitus. Curr. Diab. Rep. 2005;5:171–176
- Effect of intravenous infusion of exenatide (synthetic exendin-4) on glucose-dependent insulin secretion and counterregulation during hypoglycemia. Diabetes. 2004;53:2397–2403
- . Diabetes due to a progressive defect in beta-cell mass in rats transgenic for human islet amyloid polypeptide (HIP Rat): a new model for type 2 diabetes. Diabetes. 2004;53:1509–1516
- . Effects of hemipancreatectomy on insulin secretion and glucose tolerance in healthy humans. N. Engl. J. Med. 1990;322:898–903
- Measures of insulin responses as predictive markers of pancreatic beta-cell mass in normal and beta-cell reduced lean and obese Gottingen minipigs in vivo. Am. J. Physiol. 2005;
- . Assignment of N-acetyl-d-glucosaminidase (Mgea5) to rat chromosome 1q5 by tyramide fluorescence in situ hybridization (T-FISH): synteny between rat, mouse and human with insulin degradation enzyme (IDE). Cytogenet. Genome Res. 2003;103:202B
- Peroxisome proliferator-activated receptor (PPAR)-alpha activation prevents diabetes in OLETF rats: comparison with PPAR-gamma activation. Diabetes. 2003;52:2331–2337
- Free fatty acid-induced beta-cell defects are dependent on uncoupling protein 2 expression. J. Biol. Chem. 2004;279:51049–51056
- Increased uncoupling protein-2 levels in beta-cells are associated with impaired glucose-stimulated insulin secretion: mechanism of action. Diabetes. 2001;50:1302–1310
- . JNK: bridging the insulin signaling and inflammatory pathway. Curr. Opin. Invest. Drugs. 2005;6:979–987
- . Inflammatory blockade improves human pancreatic islet function and viability. Am. J. Transplant. 2005;5:475–483
- . Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes. J. Mol. Med. 2003;81:455–470
- The long-acting glucagon-like peptide-1 analogue, liraglutide, inhibits beta-cell apoptosis in vitro. Biochem. Biophys. Res. Commun. 2005;330:577–584
- . The role of GLP-1 in the life and death of pancreatic beta cells. Horm. Metab. Res. 2004;36:804–810
- . Neonatal exendin-4 prevents the development of diabetes in the intrauterine growth retarded rat. Diabetes. 2003;52:734–740
- . Persistent improvement of type 2 diabetes in the Goto-Kakizaki rat model by expansion of the beta-cell mass during the prediabetic period with glucagon-like peptide-1 or exendin-4. Diabetes. 2002;51:1443–1452
- . Glucagon-like peptide-1 and exendin-4 stimulate beta-cell neogenesis in streptozotocin-treated newborn rats resulting in persistently improved glucose homeostasis at adult age. Diabetes. 2001;50:1562–1570
- Comparison of pioglitazone and gliclazide in sustaining glycemic control over 2 years in patients with type 2 diabetes. Diabetes Care. 2005;28:544–550
PII: S0168-8227(06)00283-X
doi: 10.1016/j.diabres.2006.06.014
© 2006 Elsevier Ireland Ltd. All rights reserved.
« Previous
Diabetes Research and Clinical Practice
Volume 74, Issue 2,
Supplement
, Pages S63-S69
, 30 November 2006
