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Diabetes Research and Clinical Practice
Volume 74, Issue 2,
Supplement
, Pages S51-S62
, 30 November 2006
Engineered antibodies: A new tool for use in diabetes research
References
- . The mechanism of diphtheria immunity and tetanus immunity in animals. Mol. Immunol. 1890;28(12):1319–13201317
- . On structural and functional relations between antibodies and proteins of the gamma-system. Proc. Natl. Acad. Sci. U.S.A. 1962;48:1035–1042
- Amino acid sequence of a mouse immunoglobulin μ chain. Proc. Natl. Acad. Sci. U.S.A. 1979;76(6):2932–2936
- . An analysis of the sequences of the variable regions of Bence-Jones proteins and myeloma light chains and their implication for antibody complementarity. J. Exp. Med. 1970;132:211–249
- . Attempts to locate complementarity-determining residues in the variable positions of light and heavy chains. Ann. NY Acad. Sci. 1971;190:382–393
- . General motors cancer research foundation awards: monoclonal antibodies. Cancer. 1982;49(10):1953–1957
- . Phage display technology: clinical applications and recent innovations. Clin. Biochem. 2002;35:425–445
- Rearrangement of genetic information may produce immunoglobulin diversity. Nature. 1978;276(5690):785–790
- . Sets of immunoglobulin V kappa genes homologous to ten cloned V kappa sequences: implications for the number of germline V kappa genes. J. Mol. Appl. Genet. 1981;1(2):103–116
- . Asymmetric contribution to Ig repertoire diversity by V kappa exons: differences in the utilization of V kappa 10 exons. J. Immunol. 1998;161(5):2290–2300
- . Complete immunoglobulin gene is created by somatic recombination. Cell. 1978;15:1–14
- An immunoglobulin heavy-chain gene is formed by at least two recombinational events. Nature. 1980;283(5749):733–739
- . Continuous cultures of fused cells secreting antibody of predefined specificity. Nature. 1975;256(5517):495–497
- Human antibodies with sub-nanomolar affinities isolated from a large non-immunised phage display library. Nat. Biotechnol. 1996;14(3):309–314
- . Man-made antibodies. Nature. 1991;349(6307):293–299
- . Chimeric human antibody molecules: mouse antigen-binding domains with human constant region domains. Proc. Natl. Acad. Sci. U.S.A. 1984;81(21):6851–6855
- . Engineering antibodies for therapy. Immunol. Rev. 1992;130:5–40
- Replacing the complementarity-determining regions in a human antibody with those from a mouse. Nature. 1986;321(6069):522–525
- . Reshaping human antibodies: grafting an antilysozyme activity. Science. 1988;239(4847):1534–1536
- . SDR grafting—a new approach to antibody humanization. Methods. 2005;36(1):25–34
- Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 1988;85:5879–5883
- . Single domain antibodies: comparison of camel VH and camelised human VH domains. J. Immunol. Meth. 1999;231:25–38
- Recombinant Fabs of human monoclonal antibodies specific to the middle epitope of GAD65 inhibit type 1 diabetes-specific GAD65Abs. Diabetes. 2003;52(11):2689–2695
- Epitope analysis of insulin autoantibodies using recombinant Fab. Clin. Exp. Immunol. 2005;140(3):564–571
- Dynamic changes of GAD65 autoantibody epitope specificities in individuals at risk of developing type 1 diabetes. Diabetologia. 2005;48(5):922–930
- . A comparison of strategies to stabilize immunoglobulin Fv-fragments. Biochemistry. 1990;29(6):1362–1367
- Single-chain antigen-binding proteins. Science. 1988;243:423–426
- Synthesis and expression in Escherichia coli of cistronic DNA encoding an antibody fragment specific for a Salmonella serotype B O-antigen. Gene. 1991;100:39–44
- An active single-chain antibody containing a cellulase linker domain is secreted by Escherichia coli. Protein Eng. 1991;4(7):837–841
- . Construction, characterization, and mutagenesis of an anti-fluorescein single chain antibody idiotype family. J. Biol. Chem. 1992;267(13):8925–8931
- Recombinant antineuraminidase single chain antibody: expression, characterization, and crystallization in complex with antigen. Proteins. 1993;16(1):57–63
- . Recombinant single-chain antibody peptide conjugates expressed in Escherichia coli for the rapid diagnosis of HIV. J. Immunol. Meth. 1994;171(2):211–226
- . Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface. Science. 1985;228(4705):1315–1317
- . Miniantibodies: use of amphipathic helices to produce functional, flexibly linked dimeric FV fragments with high avidity in Escherichia coli. Biochemistry. 1992;31(6):1579–1584
- . The first constant domain (C(H)1 and C(L)) of an antibody used as heterodimerization domain for bispecific miniantibodies. FEBS Lett. 1998;422(2):259–264
- Minibody: a novel engineered anti-carcinoembryonic antigen antibody fragment (single-chain Fv-CH3) which exhibits rapid, high-level targeting of xenografts. Cancer Res. 1996;56(13):3055–3061
- Highly specific in vivo tumor targeting by monovalent and divalent forms of 741F8 anti-c-erbB-2 single-chain Fv. Cancer Res. 1993;53(17):4026–4034
- . Diabodies: small bivalent and bispecific antibody fragments. Proc. Natl. Acad. Sci. U.S.A. 1993;90(14):6444–6448
- . Triabodies: single chain Fv fragments without a linker form trivalent trimers. FEBS Lett. 1997;409(3):437–441
- . Phage antibodies: filamentous phage displaying antibody variable domains. Nature. 1990;348(6301):552–554
- . Antibody-selectable filamentous fd phage vectors: affinity purification of target genes. Gene. 1988;73(2):305–318
- . Cell selection strategies for making antibodies from variable gene libraries: trapping the memory pool. Eur. J. Immunol. 1992;22:867–870
- . Generation of diverse high-affinity human monoclonal antibodies by repertoire cloning. Proc. Natl. Acad. Sci. U.S.A. 1991;88:2432–2436
- Simultaneous mutagenesis of antibody CDR regions by overlap extension and PCR. Biotechniques. 1994;17(2):314–315310, 312
- Design and use of a phage display library. Human antibodies with subnanomolar affinity against a marker of angiogenesis eluted from a two-dimensional gel. J. Biol. Chem. 1998;273(34):21769–21776
- Neutralizing human Fab fragments against measles virus recovered by phage display. J. Virol. 2002;76(1):251–258
- Rapid cloning of rearranged immunoglobulin genes from human hybridoma cells using mixed primers and the polymerase chain reaction. Biochem. Biophys. Res. Commun. 1989;160(3):1250–1256
- Human combinatorial antibody libraries to hepatitis B surface antigen. Proc. Natl. Acad. Sci. U.S.A. 1992;89(8):3175–3179
- Efficient construction of a large nonimmune phage antibody library: the production of high affinity human single-chain antibodies to protein antigens. Proc. Natl. Acad. Sci. U.S.A. 1998;95:6157–6162
- Linkage of recognition and replication functions by assembling combinatorial antibody Fab libraries along phage surfaces. Proc. Natl. Acad. Sci. U.S.A. 1991;88(10):4363–4366
- . Assembly of combinatorial antibody libraries on phage surfaces: the gene III site. Proc. Natl. Acad. Sci. U.S.A. 1991;88(18):7978–7982
- . Filter screening of antibody Fab fragments secreted from individual bacterial colonies: specific detection of antigen binding with a two-membrane system. Anal. Biochem. 1991;196(1):151–155
- Isolation of high affinity human antibodies directly from large synthetic repertoires. EMBO J. 1994;13(14):3245–3260
- Discovery of human antibodies to cell surface antigens by capture lift screening of phage-expressed antibody libraries. Anal. Biochem. 1998;256(2):169–177
- . Efficient in vitro affinity maturation of phage antibodies using BIAcore guided selections. Hum Antibodies Hybridomas. 1996;7(3):97–105
- . In vitro selection, and evolution of functional proteins by using ribosome display. Proc. Natl. Acad. Sci. U.S.A. 1997;94:4937–4942
- . Ribosome display: an in vitro method for selection and evolution of antibodies from libraries. J. Immunol. Meth. 1999;231:119–135
- Human antibody production in transgenic mice: expression from 100
kb of the human IgH locus. Eur. J. Immunol. 1991;21(5):1323–1326 - . Production of human antibody repertoires in transgenic mice. Curr. Opin. Biotechnol. 1997;8(4):455–458
- . The hu-PBL-SCID mouse model. Long-term human serologic evolution associated with the xenogeneic transfer of human peripheral blood leukocytes into SCID mice. Cell. Immunol. 1992;139(2):468–477
- . Rapid tumor penetration of a single-chain Fv and comparison with other immunoglobulin forms. Cancer Res. 1992;52(12):3402–3408
- Expression of nm23-H1 Gene and Sialyl Lewis X antigen in breast cancer. Oncology. 1998;55:357–362
- Analysis of GAD65 autoantibodies in Stiff-Person syndrome patients. J. Immunol. 2005;175(11):7755–7762
- High diagnostic sensitivity of glutamate decarboxylase autoantibodies in insulin-dependent diabetes mellitus with clinical onset between age 20 and 40 years. The Belgian Diabetes Registry. J. Clin. Endocrinol. Metab. 1995;80(3):846–851
- Suppressive effect of glutamic acid decarboxylase 65-specific autoimmune B lymphocytes on processing of T cell determinants located within the antibody epitope. J. Immunol. 2002;169(2):665–672
- . GAD65-specific autoantibodies enhance the presentation of an immunodominant T-cell epitope from GAD65. Diabetes. 2000;49(10):1621–1626
- Autoantigenic properties of native and denatured glutamic acid decarboxylase: evidence for a conformational epitope. Clin. Immunol. Immunopathol. 1994;71(1):53–59
- High-resolution autoreactive epitope mapping and structural modeling of the 65
kDa form of human glutamic acid decarboxylase. J. Mol. Biol. 1999;287(5):983–999 - . Two distinct glutamic acid decarboxylase auto-antibody specificities in IDDM target difference epitopes. Diabetes. 1995;44(2):216–220
- Recognition of glutamic acid decarboxylase (GAD) by autoantibodies from different GAD antibody-positive phenotypes. J. Clin. Endocrinol. Metab. 2000;85(12):4671–4679
- . GAD autoantibodies in IDDM, Stiff-Man Syndrome, and autoimmune polyendocrine syndrome type I recognize different epitopes. Diabetes. 1994;43:161–165
- . Glutamic acid decarboxylase autoantibodies in Stiff-Man syndrome and insulin-dependent diabetes mellitus exhibit similarities and differences in epitope recognition. J. Immunol. 1996;156(2):818–825
- Murine monoclonal glutamic acid decarboxylase (GAD)65 antibodies recognize autoimmune-associated GAD epitope regions targeted in patients with type 1 diabetes mellitus and Stiff-Man syndrome. Acta Diabetol. 1996;33(3):225–231
- Autoantibody recognition of COOH-terminal epitopes of GAD65 marks the risk for insulin requirement in adult-onset diabetes mellitus. J. Clin. Endocrinol. Metab. 2000;85(1):309–316
- . Maturation of the humoral autoimmune response to epitopes of GAD in preclinical childhood type 1 diabetes. Diabetes. 2000;49(2):202–208
- Modulation of antigen processing by bound antibodies can boost or suppress class II major histocompatibility complex presentation of different T cell determinants. J. Exp. Med. 1995;181(6):1957–1963
- . Capture and processing of exogenous antigens for presentation on MHC molecules. Annu. Rev. Immunol. 1997;15:821–850
- . Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: the 2-year analysis of the German BABYDIAB Study. Diabetes. 1999;48:460–468
- Genetic effects on age-dependent onset and islet cell autoantibody markers in type 1 diabetes. Diabetes. 2002;51(5):1346–1355
- A comparison of childhood and adult type I diabetes mellitus. N. Engl. J. Med. 1989;320(14):881–886
- . Differences in epitope restriction of autoantibodies to native human insulin (IAA) and antibodies to heterologous insulin (IA). Diabetes. 1987;36(1):66–72
- Insulin autoantibody polymorphisms with greater discrimination for diabetes in humans. Diabetologia. 1988;31:670–674
- The use of phage display to distinguish insulin autoantibody (IAA) from insulin antibody (IA) idiotypes. Diabetologia. 2003;46:802–809
- Sensitive monoclonal antibody-based sandwich ELISA for determination of the diabetes-associated autoantigen glutamic acid decarboxylase GAD65. J. Immunoassay. 1997;18:289–307
- Human monoclonal antibodies isolated from type I diabetes patients define multiple epitopes in the protein tyrosine phosphatase-like IA-2 antigen. J. Immunol. 2000;165:4676–4684
- . Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23). Proc. Natl. Acad. Sci. U.S.A. 1996;93:956–960
- . Global burden of diabetes, 1995–2025: prevalence, numerical estimates, and projections. Diab. Care. 1998;21(9):1414–1431
- Fasting proinsulin concentrations predict the development of type 2 diabetes. Diab. Care. 1999;22(2):262–270
- Sensitive and specific two-site immunoradiometric assays for human insulin, proinsulin, 65–66 split proinsulin and 32–33 split proinsulins. Biochem. J. 1989;260:535–541
- Use of an in vivo biotinylated single-chain antibody as capture reagent in an immunometric assay to decrease the incidence of interference from heterophilic antibodies. Clin. Chem. 2005;51(5):830–838
- . Plasma insulin concentrations in nondiabetic and early diabetic subjects. Determinations by a new sensitive immuno-assay technic. Diabetes. 1959;9(4):254–260
- . Antibody engineering for the development of therapeutic antibodies. Mol. Cells. 2005;20(1):17–29
- . Molecular evolution of proteins on filamentous phage. J. Biol. Chem. 1992;267(23):16007–16010
- . Engineered antibodies. Nature Med. 2003;9(1):129–134
- Epitope analysis of GAD65Ab using fusion proteins and rFab. J. Immunol. Meth. 2004;295:101–109
- Fasting proinsulin and 2-h post-load glucose levels predict the conversion to NIDDM in subjects with impaired glucose tolerance: the Hoorn Study. Diabetologia. 1996;39(1):113–118
PII: S0168-8227(06)00282-8
doi: 10.1016/j.diabres.2006.06.033
© 2006 Elsevier Ireland Ltd. All rights reserved.
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Diabetes Research and Clinical Practice
Volume 74, Issue 2,
Supplement
, Pages S51-S62
, 30 November 2006
