Diabetes Research and Clinical Practice
Volume 75, Issue 1 , Pages 27-29 , January 2007

A patient with Werner syndrome and adiponectin gene mutation

  • Naotake Hashimoto

      Affiliations

    • Department of Internal Medicine, Asahi General Hospital, I-1326, Asahi, Chiba 289-2511, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 479 63 8111; fax: +81 479 60 1210.
    • ,
  • Sachiko Hatanaka

      Affiliations

    • Department of Internal Medicine, Naruto Hospital, Japan
    • ,
  • Koutaro Yokote

      Affiliations

    • Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, Japan
    • ,
  • Hiroko Kurosawa

      Affiliations

    • Department of Internal Medicine, Asahi General Hospital, I-1326, Asahi, Chiba 289-2511, Japan
    • ,
  • Tomohiko Yoshida

      Affiliations

    • Department of Internal Medicine, Naruto Hospital, Japan
    • ,
  • Rie Iwai

      Affiliations

    • Department of Clinical Laboratory, Asahi General Hospital, I-1326, Asahi, Chiba 289-2511, Japan
    • ,
  • Hidenori Takahashi

      Affiliations

    • Department of Clinical Laboratory, Asahi General Hospital, I-1326, Asahi, Chiba 289-2511, Japan
    • ,
  • Katsuya Yoshida

      Affiliations

    • Department of Internal Medicine, Asahi General Hospital, I-1326, Asahi, Chiba 289-2511, Japan
    • ,
  • Atsuya Horie

      Affiliations

    • Department of Internal Medicine, Asahi General Hospital, I-1326, Asahi, Chiba 289-2511, Japan
    • ,
  • Kenichi Sakurai

      Affiliations

    • Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, Japan
    • ,
  • Kazuo Yagui

      Affiliations

    • Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, Japan
    • ,
  • Yasushi Saito

      Affiliations

    • Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, Japan
    • ,
  • Shouji Yoshida

      Affiliations

    • Department of Internal Medicine, Asahi General Hospital, I-1326, Asahi, Chiba 289-2511, Japan

Received 6 October 2005 ,Revised 20 April 2006 ,Accepted 9 May 2006.

References 

  1. Martin GM. Genetic syndromes in man with potential relevance to the pathophysiology of aging. Birth Defects Orig. Artic. Ser. 1978;14:5–39
  2. Goto M. Clinical characteristics of Werner syndrome and other premature aging syndromes: pattern of aging in progeroid syndrome. In:  Goto M,  Miller RW editor. In From Premature Gray Hair to Helicase-Werner Syndrome: Implication for Aging and Cancer. Basel: Karger; 2001;p. 27–39
  3. Yu CE, Oshima J, Fu YH, Wijsman EM, Hisama F, Alisch R, et al. Positional cloning of the Werner's syndrome gene. Science. 1996;272:258–262
  4. Matsumoto T, Imamura O, Yamabe Y, Kuromitsu I, Tokutake Y, Shimamoto A, et al. Mutation and haplotype analysis of the Werner's syndrome gene based on its genomic structure: genetic epidemiology in the Japanese populations. Hum. Genet. 1997;100:123–130
  5. Yokote K, Hara K, Mori S, Kadowaki T, Saito Y, Goto M. Dysadipocytokinemia in Werner syndrome and its recovery by treatment with pioglitazone. Diabetes Care (Lett.). 2004;27:2562–2563
  6. Kondo H, Shimomura I, Matsukawa Y, Kumada M, Takahashi M, Matsuda M, et al. Association of adiponectin mutation with type 2 diabetes: a candidate gene for the insulin resistance syndrome. Diabetes. 2002;51:2325–2328
  7. Waki H, Yamauchi T, Kamon J, Ito Y, Uchida S, Kita S, et al. Impaired multimerization of human adiponectin mutant associated with diabetes. J. Biol. Chem. 2003;278:40352–40363
  8. Kishida K, Nagaretani H, Kondo H, Kobayashi H, Tanaka S, Maeda N, et al. Disturbed secretion of mutant adiponectin associated with the metabolic syndrome. Biochem. Biophys. Res. Commun. 2003;306:286–292

PII: S0168-8227(06)00224-5

doi: 10.1016/j.diabres.2006.05.010

Diabetes Research and Clinical Practice
Volume 75, Issue 1 , Pages 27-29 , January 2007

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