Diabetes Research and Clinical Practice
Volume 75, Issue 1 , Pages 2-6 , January 2007

Leptin, triglycerides, and interleukin 6 are independently associated with C-reactive protein in Japanese type 2 diabetic patients

  • Takiko Yanagawa

      Affiliations

    • Division of Diabetes and clinical Nutrition, Kansai-Denryoku Hospital, Osaka Japan
    • ,
  • Ataru Taniguchi

      Affiliations

    • Division of Diabetes and clinical Nutrition, Kansai-Denryoku Hospital, Osaka Japan
    • Corresponding Author InformationCorresponding author at: Division of Diabetes and Clinical Nutrition, Kansai-Denryoku Hospital, 2-1-7 Fukushima, Fukushima-ku, Osaka-city, Osaka 553-0003, Japan. Fax: +81 6 6458 6994.
    • ,
  • Mitsuo Fukushima

      Affiliations

    • Department of Health Informatics Research, Translational Research Informatics Center, Kobe, Japan
    • ,
  • Yoshikatsu Nakai

      Affiliations

    • School of Health Sciences Faculty of Medicine, Kyoto University, Kyoto, Japan
    • ,
  • Shoichiro Nagasaka

      Affiliations

    • Division of Endocrinology and Metabolism,Jichi Medical School, Tochigi, Japan
    • ,
  • Minako Ohgushi

      Affiliations

    • Division of Diabetes and clinical Nutrition, Kansai-Denryoku Hospital, Osaka Japan
    • ,
  • Kazunari Matsumoto

      Affiliations

    • Diabetes Center, Sasebo Chuoh Hospital, Nagasaki, Japan
    • ,
  • Akira Kuroe

      Affiliations

    • Division of Diabetes and clinical Nutrition, Kansai-Denryoku Hospital, Osaka Japan
    • ,
  • Michihiro Ohya

      Affiliations

    • Division of Diabetes and clinical Nutrition, Kansai-Denryoku Hospital, Osaka Japan
    • ,
  • Yutaka Seino

      Affiliations

    • Division of Diabetes and clinical Nutrition, Kansai-Denryoku Hospital, Osaka Japan

Received 22 February 2006 ,Revised 7 April 2006 ,Accepted 26 April 2006.

References 

  1. Bierman EL, George L. Duff memorial lecture atherogenesis in diabetes. Arterioscler. Thromb. 1992;12:647–656
  2. Kuller L, Tracy R, Shaten J, Meilahn EN. Relationship of C-reactive protein and coronary heart disease in the MRFIT nested case-control study. Am. J. Epidemiol. 1996;144:537–547
  3. Ridker PM, Cushman M, Stampfer MJ, Tracy RP, Hennekens CH. Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N. Eng. J. Med. 1997;336:973–979
  4. Koenig W, Sund M, Frohlich M, et al. C-reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men. Results from the MONICA (Monitoring Trends and Determinants in Cardiovascular Disease) Ausburg Cohort Study. Circulation. 1999;99:237–242
  5. Tracy R, Lemaitre R, Psaty B, et al. Relationship of C-reactive protein to cardiovascular disease in the elderly: Results from the Cardiovascular Health Study and the Rural Health Promotion Project. Arterioscler. Thromb. Vasc. Biol. 1997;17:1112–1121
  6. Danesh J, Collins R, Peto R. Chronic infections and coronary heart disease. Is there a link?. Lancet. 1997;350:430–436
  7. Matsumoto K, Sera Y, Abe Y, Ueki Y, Tominaga T, Miyake S. Inflammation and insulin resistance are independently related to all-cause of death and cardiovascular events in Japanese patients with type 2 diabetes mellitus. Atherosclerosis. 2003;169:317–321
  8. Halaas JL, Gajiwara KS, Maffei M, et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science. 1995;269:543–546
  9. Haffner SM, Mykkanen L, Rainwater D, Karhapaa P, Laakso M. Is leptin concentration associated with the insulin resistance syndrome in nondiabetic men?. Obes. Res. 1999;7:164–169
  10. Wallace AM, McMahon AD, Packard CJ, et al. Plasma leptin and the risk fo cardiovascular disease in the west of scotland coronary prevention study (WOSCOPS). Circulation. 2001;104:3052–3056
  11. McNeely MJ, Boyko EJ, Weigle DS, et al. Association between baseline plasma leptin levels and subsequent development of diabetes in Japanese Americans. Diabetes Care. 1999;22:65–70
  12. World Health Organization: Diabetes Mellitus: Report of a WHO Study Group. Geneva, World Health Org., 1985 (Tech. Rep. Ser., no. 727)
  13. Taniguchi A, Nagasaka S, Fukushima M, et al. C-reactive protein and insulin resistance in non-obese Japanese type 2 diabetic patients. Metabolism. 2002;51:1578–1581
  14. Fernandez-Real JM, Broch M, Vendrell J, et al. Interleukin-6 gene polymorphism and insulin sensitivity. Diabetes. 2000;49:517–520
  15. Okumura T, Taniguchi A, Nagasaka S, et al. Relationship of regional adiposity to serum leptin level in nonobese Japanese type 2 diabetic male patients. Diabetes Metab. 2003;29:15–18
  16. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and B-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–419
  17. Groop LC. Drug treatement of non-insulin-dependent diabetes mellitus, in: J. Pickup, G. Williams (Eds.), Textbook of Diabetes, Oxford, UK. Blackwell. 1997;8:1–18
  18. Bonora E, Targher G, Alberiche M, Bonadonna RC, Saggiani F, Zenere M, et al. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity. Diabetes Care. 2000;23:57–63
  19. Emoto M, Nishizawa Y, Maekawa K, Hiura Y, Kanda H, Kawagichi T, et al. Homeostasis model assessment as a clinical index of insulin resistance in type 2 diabetic patients treated with sulfonylureas. Diabetes Care. 1999;22:818–822
  20. Fuller H, Shipley MJ, Rose G, Jarrett RJ, Keen H. Coronary heart disease risk and impaired glucose tolerance. Lancet. 1980;1:1373–1376
  21. Yano K, Kagan A, McGee D, Rhoads GG. Glucose intolerance and nine-year mortality in Japanese men in Hawaii. Am. J. Med. 1982;72:71–80
  22. Diabetes Drafting Group . Prevalence of small vessel and large vessel disease in diabetic persons from 14 centers. the World Health Organization multinational study of vascular disease in diabetics. Diabetologia. 1985;28:615–640
  23. Herman JB, Medalie JH, Goldbourt U. Differences in cardiovascular morbidity and mortality between previously known and newly diagnosed adult diabetics. Diabetologia. 1977;13:229–234
  24. Saremi A, Nelson RG, Tulloch-Reid M, et al. Periodontal disease and mortality in type 2 diabetes. Diabetes Care. 2005;28:27–32
  25. Taniguchi A, Nishimura F, Murayama Y, et al. Porphyromonas gingivalis infection is associated with carotid atherosclerosis in non-obese Japanese type 2 diabetic patients. Metabolism. 2003;52:142–145
  26. Kuroe A, Taniguchi A, Sekiguchi A, et al. Prevalence of periodontal bacterial infection in nonobese Japanese type 2 diabetic patients. Horm. Metab. Res. 2004;36:116–118
  27. Taniguchi A, Nakai Y, Sakai M, et al. Relationship of regional adiposity to insulin resistance and serum triglyceride levels in nonobese Japanese type 2 diabetic patients. Metabolism. 2002;51:544–548
  28. Xu H, Barnes GT, Yang Q, et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J. Clin. Invest. 2003;112:1821–1830
  29. Yudkin JS, Stehouwer CD, Emeis JJ, Coppack SW. C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue?. Arterioscler. Thromb. Vasc. Biol. 1999;19:972–978
  30. Abassi F, Carantoni M, McLaughlin , Reaven GM. Plasma insulin concentration is more tightly linked to plasma leptin concentration than is the body mass index. Metabolism. 2000;49:544–547
  31. Cnop M, Landchild MJ, Vidal J, et al. The concurrent accumulation of intra-abdominal and subcutaneous fat explains the association between insulin resistance and plasma leptin concentrations. Distinct metabolic effects of two fat compartments. Diabetes. 2002;51:1005–1015
  32. Bastard JP, Jardel C, Bruckert E, et al. Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss. J. Clin. Endocrinol. Metab. 2000;85:3338–3342
  33. Nakata M, Yada T, Soejima N, Maruyama I. Leptin promotes aggregation of human platelets via the long form of ite receptor. Diabetes. 1999;48:426–429
  34. Bodary PF, Westrick RJ, Weckenheiser KJ, Shen Y, Eitzman DT. Effect of leptin on arterial thrombosis following vascular injury in mice. JAMA. 2002;287:1706–1709
  35. Kazumi T, Kawaguchi A, Hirano T, Yoshino G. C-reactive protein in young, apparently healthy men: association with serum leptin, QTc, and high density lipoprotein–-cholesterol. Metabolism. 2000;52:1113–1116
  36. Cleland SJ, Sattar N, Petrie JR, Forouhi NG, Elliott HL, Connell JMC. Sensitive C-reactive protein and basal endothelial function. Clin. Sci. 2000;98:531–535

PII: S0168-8227(06)00173-2

doi: 10.1016/j.diabres.2006.04.019

Diabetes Research and Clinical Practice
Volume 75, Issue 1 , Pages 2-6 , January 2007

Article Tools