Diabetes Research and Clinical Practice
Volume 75, Issue 1 , Pages 2-6, January 2007

Leptin, triglycerides, and interleukin 6 are independently associated with C-reactive protein in Japanese type 2 diabetic patients

  • Takiko Yanagawa

      Affiliations

    • Division of Diabetes and clinical Nutrition, Kansai-Denryoku Hospital, Osaka Japan
  • ,
  • Ataru Taniguchi

      Affiliations

    • Division of Diabetes and clinical Nutrition, Kansai-Denryoku Hospital, Osaka Japan
    • Corresponding Author InformationCorresponding author at: Division of Diabetes and Clinical Nutrition, Kansai-Denryoku Hospital, 2-1-7 Fukushima, Fukushima-ku, Osaka-city, Osaka 553-0003, Japan. Fax: +81 6 6458 6994.
  • ,
  • Mitsuo Fukushima

      Affiliations

    • Department of Health Informatics Research, Translational Research Informatics Center, Kobe, Japan
  • ,
  • Yoshikatsu Nakai

      Affiliations

    • School of Health Sciences Faculty of Medicine, Kyoto University, Kyoto, Japan
  • ,
  • Shoichiro Nagasaka

      Affiliations

    • Division of Endocrinology and Metabolism,Jichi Medical School, Tochigi, Japan
  • ,
  • Minako Ohgushi

      Affiliations

    • Division of Diabetes and clinical Nutrition, Kansai-Denryoku Hospital, Osaka Japan
  • ,
  • Kazunari Matsumoto

      Affiliations

    • Diabetes Center, Sasebo Chuoh Hospital, Nagasaki, Japan
  • ,
  • Akira Kuroe

      Affiliations

    • Division of Diabetes and clinical Nutrition, Kansai-Denryoku Hospital, Osaka Japan
  • ,
  • Michihiro Ohya

      Affiliations

    • Division of Diabetes and clinical Nutrition, Kansai-Denryoku Hospital, Osaka Japan
  • ,
  • Yutaka Seino

      Affiliations

    • Division of Diabetes and clinical Nutrition, Kansai-Denryoku Hospital, Osaka Japan

Received 22 February 2006; received in revised form 7 April 2006; accepted 26 April 2006. published online 08 June 2006.

Abstract 

The aim of the present study was to investigate the factors contributing to the concentration of serum C-reactive protein in type 2 diabetic patients. One hundred and 48 Japanese type 2 diabetic patients were studied. In conjunction with C-reactive protein (CRP), BMI, systolic and diastolic blood pressure, glycosylated hemoglobin (HbA1c), fasting concentrations of plasma glucose, and serum lipids (triglycerides, HDL cholesterol, and total cholesterol), interleukin 6 (IL-6), and leptin were measured. Insulin resistance was also estimated by the insulin resistance index of homeostasis model assessment (HOMA-IR). With univariate analysis, serum CRP was positively correlated with BMI (r=0.281, P<0.001), diastolic blood pressure (r=0.176, P=0.048), triglycerides (r=0.293, P<0.001), HOMA-IR (r=0.294, P<0.001), IL-6 (r=0.323, P<0.001), and leptin (r=0.330, P<0.001), and negatively correlated with HDL cholesterol (r=−0.181, P=0.028). Multiple regression analyses showed that serum CRP was independently predicted by the level of IL-6 (P<0.001, F=4.04), leptin (P<0.001, F=7.09), and triglycerides (P<0.001, F=15.13), which explained 17.6% of the variability of serum CRP concentration in these patients. From these results, it can be concluded that along with IL-6 and triglycerides, leptin is another important independent factor that is associated with CRP in Japanese type 2 diabetic patients.

Keywords: Leptin, CRP, IL-6, Triglycerides, Diabetes

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PII: S0168-8227(06)00173-2

doi:10.1016/j.diabres.2006.04.019

Diabetes Research and Clinical Practice
Volume 75, Issue 1 , Pages 2-6, January 2007