Diabetes Research and Clinical Practice
Volume 73, Issue 3 , Pages 241-248 , September 2006

Elevation of monocyte-derived microparticles in patients with diabetic retinopathy

  • Nahoko Ogata

      Affiliations

    • Department of Ophthalmology, Kansai Medical University, Fumizono-cho 10-15, Moriguchi, Osaka 570-8507, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 6 6992 1001; fax: +81 6 6993 2222.
  • ,
  • Shosaku Nomura

      Affiliations

    • First Department of Internal Medicine, Kansai Medical University, Moriguchi, Osaka, Japan
  • ,
  • Akira Shouzu

      Affiliations

    • Second Department of Internal Medicine, Kansai Medical University, Moriguchi, Osaka, Japan
  • ,
  • Masahito Imaizumi

      Affiliations

    • Department of Ophthalmology, Kansai Medical University, Fumizono-cho 10-15, Moriguchi, Osaka 570-8507, Japan
  • ,
  • Miwa Arichi

      Affiliations

    • Department of Ophthalmology, Kansai Medical University, Fumizono-cho 10-15, Moriguchi, Osaka 570-8507, Japan
  • ,
  • Miyo Matsumura

      Affiliations

    • Department of Ophthalmology, Kansai Medical University, Fumizono-cho 10-15, Moriguchi, Osaka 570-8507, Japan

Received 29 June 2005 ,Revised 19 January 2006 ,Accepted 30 January 2006.

References 

  1. Davis MD. Diabetic retinopathy: a clinical overview. Diab. Care. 1993;15:1844–1873
  2. Kohner EM, Chibber R. In:  Tooke JE editors. Diabetic Retinopathy. Diabetic Angiography. Oxford, UK: Oxford University Press; 1997;p. 233–247
  3. Schroder S, Palinski W, Schmid-Schobein GW. Activated monocytes and granulocytes, capillary non-perfusion and neovascularization in diabetic retinopathy. Am. J. Pathol. 1991;139:81–100
  4. Osnes LTN, Westvik AB, Kieruf P. Procoagulant and profibrinolytic activities of cryopreserved human monocytes. Thromb. Res. 1994;76:373–383
  5. Mustrard JF, Packham MA. Platelets and diabetes mellitus. New Engl. J. Med. 1984;311:665–666
  6. Aoki I, Shimoyama K, Aoki N, Homori M, Yanagisawa A, Nakahara K, et al. Platelet-dependent thrombin generation in patients with diabetes mellitus: effects of glycemic control on coagulability in diabetes. J. Am. Coll. Cardiol. 1996;27:560–566
  7. Aupeix K, Hugel B, Martin T, Bischoff P, Lill H, Pasquali JL, et al. The significance of shed membrane particles during programmed cell death in vitro, and in vivo, in HIV infection. J. Clin. Invest. 1997;99:1546–1554
  8. Zwaal RF, Comfurius P, Bevers EM. Platelet procoagulant activity and microvesicle formation: its putative role in hemostasis and thrombosis. Biochem. Biophys. Acta. 1992;1180:1–8
  9. Omoto S, Nomura S, Shouzu A, Nishikawa M, Fukuhara S, Iwasaka T. Detection of monocyte-derived microparticles in patients with type II diabetes mellitus. Diabetologia. 2002;45:550–555
  10. Sabatier F, Darmon P, Hugel B, Combes V, Sanmarco M, Velut JG, et al. Type 1 and type 2 diabetic patients display different patterns of cellular microparticles. Diabetes. 2002;51:2820–2845
  11. Satta N, Toti F, Feugeas O, Bohbot A, Dachary-Prigent J, Eschwege V, et al. Monocytes vesiculation is a possible mechanism for dissemination of membrane-associated procoagulant activities and adhesion molecules after lipopolysaccharide. J. Immunol. 1994;153:3245–3255
  12. Mesri M, Altieri DC. Endothelial cell activation by leukocyte microparticles. J. Immunol. 1998;161:4382–4387
  13. Robinson RA, Worfolk L, Tracy PB. Endotoxin enhances the expression of monocytes prothrombinase activity. Blood. 1992;79:406–416
  14. Mallat Z, Benamer H, Hugel B, Benessiano J, Steg PG, Freyssinet JM, et al. Elevated levels of shed membrane microparticles with procoagulant potential in the peripheral circulating blood of patients with acute coronary syndromes. Circulation. 2000;101:841–843
  15. Fukumoto H, Naito Z, Asano G, Aramaki T. Immunohistochemical and morphmetric evaluation of coronary atherosclerotic plagues associated myocardial infarction and diabetic mellitus. J. Atheroscler. Thromb. 1998;5:29–35
  16. Ogata N, Imaizumi M, Nomura S, Shozu A, Arichi M, Matsuoka M, et al. Increased levels of platelet-derived microparticles in patients with diabetic retinopathy. Diab. Res. Clin. Pract. 2005;68:193–201
  17. Dore M, Korthuis RJ, Granger DN, Entman ML, Smith CW. P-selectin mediates spontaneous leucocyte rolling in vivo. Blood. 1993;82:1308–1316
  18. Lawrence MB, Springer TA. Leucocytes roll on selectin at physiologic flow rates: distribution from and prerequisite for adhesion through integrins. Cell. 1991;65:859–873
  19. Mayadas TN, Johnson RC, Rayburn H, Hyner RO, Wagner DD. Leucocyte rolling and extravasation are severely compromised in P-selectin-deficient mice. Cell. 1993;74:541–554
  20. Osborn L. Leucocyte adhesion to endothelium in inflammation. Cell. 1990;62:3–6
  21. Sligh JE, Ballantyne CM, Rich SS, Hawkins HK, Smith CW, Bradley A, et al. Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1. Proc. Natl. Acad. Sci. U.S.A. 1993;90:8529–8533
  22. Olson JA, Whitelaw CM, McHardy KC, Pearson DWM, Forrester JV. Soluble leucocyte adhesion molecules in diabetic retinopathy stimulate retinal capillary endothelial cell migration. Diabetologia. 1997;40:1166–1171
  23. Mcleod DS, Lefer DJ, Merges C, Lutty GA. Enhanced expression of intracellular adhesion molecule-1 and P-selectin in the diabetic human retina and choroid. Am. J. Pathol. 1995;147:642–653
  24. Wilkinson CP, Ferris FL, Klein RE, Lee PP, Agardh CD, Davis M, et al. Representing the Global Diabetic Retinopathy Project Group Proposed international clinical diabetic retinopathy and diabetic edema disease severity scales. Ophthalmology. 2003;110:1677–1682
  25. Xie GL, Nomura S, Fukuhara S. Annexin V expression and membrane vesiculation during activation of leukemic cell lines. Haemostasis. 1997;27:259–268
  26. Nomura S, Tandon NN, Nakamura T, Cone J, Fukuhara S, Kambayashi J. High-shear-stress-induced activation of platelets and microparticles enhances expression of cell adhesion molecules in THP-1 and endothelial cells. Atherosclerosis. 2001;158:277–287
  27. Nomura S, Suzuki M, Katsura K, Xie GL, Miyazaki Y, Miyake T, et al. Platelet-derived microparticles may influence the development of atherosclerosis in diabetes mellitus. Atherosclerosis. 1995;116:235–240
  28. Murakami T, Komiyama Y, Masuda M, Kido H, Nomura S, Fukuhara S, et al. Flow cytometric analysis of platelet activation markers CD62P and CD63 in patients with coronary artery disease. Eur. J. Clin. Invest. 1996;26:996–1003
  29. Kaplar M, Kappelmayer J, Veszpremi A, Szabo K, Udvardy M. The possible association of in vivo leucocyte–platelet heterophilic aggregate formation and the development of diabetic angiopathy. Platelets. 2001;12:419–422
  30. Fantone JC, Ward PA. Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions. Am. J. Pathol. 1982;107:395–418
  31. Carlos T, Harlan JM. Leucocyte–endothelial adhesion molecules. Blood. 1994;84:2068–2101
  32. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 1993;362:801–809
  33. Furie B, Furie BC. The molecular basis of blood coagulation. Cell. 1998;53:505–518
  34. Nomura S. Function and clinical significance of platelet-derived microparticles. Int. J. Hematol. 2001;74:397–404
  35. Omoto S, Nomura S, Shozu A, Hayakawa T, Shimizu H, Miyake Y, et al. Significance of platelet-derived microparticles and activated platelet in diabetic nephropathy. Nephron. 1999;81:271–277
  36. Nomura S, Shouzu A, Omoto S, Nishikaw M, Fukuhara S. Significance of chemokines and activated platelets in patients with diabetes. Clin. Exp. Immunol. 2000;121:437–443
  37. Nishiwaki A, Ueda T, Ugawa S, Shimada S, Ogura Y. Up-regulation of P-selectin and intercellular adhesion molecule-1 after retinal ischemia-reperfusion injury. Invest. Ophthalmol. Vis. Sci. 2003;44:4931–4935
  38. van Leiden HA, Dekker JM, Moll AC, Nipels G, Heine RJ, Bouter LM, et al. Risk factors for incident retinopathy in diabetic and nondiabetic population: the Hoorn study. Arch. Ophthalmol. 2003;121:245–251
  39. Stulc T, Kasalova Z, Prazny M, Vrablik M, Skrha J, Ceska R. Microvascular reactivity in patients with hypercholesterolemia: effect of lipid lowering treatment. Physiol. Res. 2003;52:439–445
  40. Barile GR, Chang SS, Parl LS, Reppucci VS, Schiff VM, Schimidt AM. Soluble cellular adhesion molecules in proliferative vitreoretinopathy and proliferative diabetic retinopathy. Curr. Eye Res. 1999;19:219–227
  41. Miyamoto K, Khosrof S, Bursell SE, Rohan R, Muraka T, Clermont AC, et al. Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition. Proc. Natl. Acad. Sci. U.S.A. 1999;96:10836–10841
  42. Chibber R, Ben-Mahmud BM, Mann GE, Zhang JJ, Kohner EM. Protein kinase Cβ2-dependent phosphorylation of core2 GlcNAc-T promotes leukocyte–endothelial cell adhesion. A mechanism underlying capillary occlusion in diabetic retinopathy. Diabetes. 2003;52:1519–1527
  43. Limb GA, Hickman-Casey J, Hollifield RD, Chignell AH. Vascular adhesion molecules in vitreous from eyes with proliferative diabetic retinopathy. Invest. Ophthalmol. Vis. Sci. 1999;40:2453–2457
  44. Barouch FC, Miyamoto K, Allport JR, Fujita K, Bursell SE, Aiello LP, et al. Integrin-mediated neutrophil adhesion and retinal leucostasis in diabetes. Invest. Ophthalmol. Vis. Sci. 2000;41:1153–1158
  45. Miyamoto K, Hiroshiba N, Tsujikawa A, Ogura Y. In vivo demonstration of increased entrapment in retinal microcirculation of diabetic rats. Invest. Ophthalmol. Vis. Sci. 1998;39:2190–2194
  46. Joussen AM, Murata T, Tsujikawa A, Kirchhof B, Bursell SE, Adamis AP. Leucocyte-mediated endothelial cell injury and death in diabetic retina. Am. J. Pathol. 2001;158:147–152

PII: S0168-8227(06)00056-8

doi: 10.1016/j.diabres.2006.01.014

Diabetes Research and Clinical Practice
Volume 73, Issue 3 , Pages 241-248 , September 2006