Diabetes Research and Clinical Practice
Volume 72, Issue 3 , Pages 251-257 , June 2006

A practical insulin infusion algorithm for the establishment of euglycaemia in both lean and obese patients with type 1 and type 2 diabetes

This work is dedicated to the memory of D. Willem Erkelens (1941–2004).

  • Alexander D.M. Stork

      Affiliations

    • Department of Internal Medicine and Metabolic Diseases, University Medical Center Utrecht, Utrecht, The Netherlands
  • ,
  • D. Willem Erkelens

      Affiliations

    • Department of Internal Medicine and Metabolic Diseases, University Medical Center Utrecht, Utrecht, The Netherlands
  • ,
  • Thiemo F. Veneman

      Affiliations

    • Department of Internal Medicine, Twenteborg Hospital, P.O. Box 7600, 7600 SZ Almelo, The Netherlands
    • Corresponding Author InformationCorresponding author.

Received 21 June 2005 ,Revised 20 October 2005 ,Accepted 26 October 2005.

References 

  1. Van den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M, et al. Intensive insulin therapy in critically ill patients. N. Engl. J. Med. 2001;345:1359–1367
  2. Finney SJ, Zekveld C, Andi E, Evans TW. Glucose control and mortality in critically ill patients. JAMA. 2003;290:2041–2047
  3. Dellinger RP, Carlet JM, Masur H, Gerlach H, Calandra T, Cohen J, et al. for the Surviving Sepsis Campaign Management Guidelines Committee Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit. Care Med. 2004;32:858–871
  4. Malmberg K, Ryden L, Efendic S, Hertlitz J, Nicol P, Waldenström A, et al. Randomized trial of insulin-glucose infusion followed by subcutaneous insulin treatment in diabetic patients with acute myocardial infarction (DIGAMI Study): effects on mortality at 1 year. J. Am. Coll. Cardiol. 1995;26:57–65
  5. Malmberg K, Norhammer A, Wedel H, Ryden L. Glycometabolic state at admission: important risk marker of mortality in conventionally treated patients with diabetes mellitus and acute myocardial infarction. Long-term results from the Diabetes and Insulin Glucose Infusion in Acute Myocardial Infarction (DIGAMI) study. Circulation. 1999;99:2626–2632
  6. Diaz R, Paolasso EA, Piegas LS, Trajer CD, Moreno MG, Corvalan R, et al. on behalf of the ECLA (Estudios Cardiologicos Latinoamerica) Collaborative Group Metabolic modulation of acute myocardial infarction. Circulation. 1998;98:2227–2234
  7. Andres R, Swerdloff R, Pozefski YT, Coleman D. Manual feedback technique for the control of blood glucose concentration. In:  Skeggs L editors. Automation in Analytical Chemistry. White Plaines, NY: Mediad; 1966;p. 486–491
  8. Clarke W, Haymond M, Santiago J. Overnight basal insulin requirements in fasting insulin dependent diabetics. Diabetes. 1980;29:78–80
  9. Bolli G, Dimitrades G, Pehling G. Abnormal glucose counterregulation after subcutaneous insulin in insulin-dependent diabetes mellitus. N. Engl. J. Med. 1984;310:1706–1711
  10. Steil GM, Panteleon AE, Rebrin K. Closed-loop insulin delivery-the path to physiological glucose control. Adv. Drug Deliv. Rev. 2004;56:125–144
  11. White NH, Skor D, Santiago JV. Practical closed-loop insuline delivery. A system for the maintenance of overnight euglycemia and the calculation of basal insulin requirements in insulin-dependent diabetics. Ann. Intern. Med. 1982;97:210–213
  12. Watts NB, Gebhart SSP, Clark RV, Phillips LS. Postoperative management of diabetes mellitus: steady state glucose control with bedside algorithm for insulin adjustment. Diabetes Care. 1987;10:722–728
  13. Mokan M, Gerich JE. A simple insulin infusion algorithm for establishing and maintaining overnight near-normoglycemia in type I and type II diabetes. J. Clin. Endocrinol. Metab. 1992;74:943–945
  14. Malmberg KA, Efendic S, Ryden LE. Feasibility of insulin-glucose infusion in diabetic patients with acute myocardial infarction. A report from the multicenter trial: DIGAMI. Diabetes Care. 1994;17:1007–1014
  15. Mao CS, Riegelhuth ME, Van Gundy D, Cortez C, Melendez S, Ipp E. An overnight insulin infusion algorithm provides morning normoglycemia and can be used to predict insulin requirements in non-insulin dependent diabetes mellitus. J. Clin. Endocrinol. Metab. 1997;82:2466–2470
  16. Dazzi D, Taddei F, Gavarini A, Uggeri E, Negro R, Pezzarossa A. The control of blood glucose in the critical diabetic patient. A neuro-fuzzy method. J. Diabetes Comp. 2001;15:80–87
  17. Bonnier M, Lönnroth P, Gudbjörnsdottir S, Attvall S, Jansson P-A. Validation of a glucose-insulin-potassium infusion algorithm in hospitalized diabetic patients. J. Int. Med. 2003;253:189–193
  18. Goldberg PA, Siegel MD, Sherwin RS, Halickman JI, Bailey VA, Lee M, et al. Implementation of a safe and effective insulin infusion protocol in a medical intensive care unit. Diabetes Care. 2004;27:461–467
  19. Caraway WT, Watts NB. Carbohydrates. In:  Tietz N editors. Textbook of Clinical Chemistry. Philadelphia, PA: WN Saunders Co.; 1986;p. 784–789
  20. Burrin JM, Alberti KGMM. What is blood glucose: can it be measured?. Diabetes Med. 1990;7:199–206
  21. Furler SM, Kraegen EW, Smallwood RH, Chisholm DJ. Blood glucose control by intermittent loop closure in the basal mode: computer simulation studies with a diabetic model. Diabetes Care. 1985;8:553–561
  22. Van den Berghe G, Wouters PJ, Bouillon R, Weekers F, Verwaest C, Schetz M, et al. Outcome benefit of intensive insulin therapy in the critically ill: insulin dose versus glycemic control. Crit. Care Med. 2003;31:359–366
  23. Petty C, Cunningham N. Insulin adsorption by glass infusion bottles, polyvinylchloride infusion containers and intravenous tubing. Anesthesiology. 1974;40:400–404
  24. Hirsch J, Wood J, Thomas R. Insulin adsorption to polylefin infusion bottles and polyvinyl chloride administration sets. Am. J. Hosp. Pharm. 1981;38:995–997
  25. Whalen FJ, LeCain WK, Latiolas CJ. Availability of insulin from continuous low-dose insulin infusions. Am. J. Hosp. Pharm. 1979;36:330–337
  26. Simeon PS, Geffner ME, Levin SR, Lindsey AM. Continuous insulin infusions in neonates: pharmacologic availability of insulin in intravenous solutions. J. Pediatr. 1994;124:818–820
  27. Fuloria M, Friedberg MA, DuRant RH, Aschner JL. Effect of flow rate and insulin priming on the recovery of insulin from microbore infusion tubing. Pediatrics. 1998;102:1401–1406
  28. Kraegen E, Lazarus L, Meier H, Campbell L, Chia Y. Carrier solutions for low-level intravenous insulin infusion. Br. Med. J. 1975;5981:464–466
  29. Weber S, Warren W, Jackson E. Availability of insulin from parenteral nutrient solutions. Am. J. Hosp. Pharm. 1977;34:353–357

PII: S0168-8227(05)00426-2

doi: 10.1016/j.diabres.2005.10.020

Diabetes Research and Clinical Practice
Volume 72, Issue 3 , Pages 251-257 , June 2006