Effect of PLC on functional parameters and oxidative profile in type 2 diabetes-associated PAD

Santo, Signorelli Salvatore; Sergio, Neri; Luigi, Di Pino; Giuseppe, Marchese; Margherita, Ferrante; Gea, Oliveri Conti; Roberto, Fallico; Gabriella, Celotta; Giuseppe, Pennisi; Massimiliano, Anzaldi

doi:10.1016/j.diabres.2005.10.007

« Previous Next »Diabetes Research and Clinical Practice
Volume 72, Issue 3 , Pages 231-237, June 2006

Effect of PLC on functional parameters and oxidative profile in type 2 diabetes-associated PAD

Signorelli Salvatore Santo
- Department of Internal Medicine and Systemic Pathology, Medical Angiology Section, Italy
- Corresponding author at: Department of Internal Medicine and Systemic Pathology, Medical Angiology Section, Via Firenze 123, I-95020 Acicastello, Italy. Tel.: +39 095 7594344; fax: +39 095 312165.
Neri Sergio
- Department of Internal Medicine and Systemic Pathology, Internal Medicine Section, Italy
Di Pino Luigi
- Department of Internal Medicine and Systemic Pathology, Medical Angiology Section, Italy
Marchese Giuseppe
- Department of Internal Medicine and Systemic Pathology, Medical Angiology Section, Italy
Ferrante Margherita
- Department of Anatomy, Diagnostic Pathology, Legal Medicine and Public Health, Faculty of Medicine, University of Catania, Italy
Oliveri Conti Gea
- Department of Anatomy, Diagnostic Pathology, Legal Medicine and Public Health, Faculty of Medicine, University of Catania, Italy
Fallico Roberto
- Department of Anatomy, Diagnostic Pathology, Legal Medicine and Public Health, Faculty of Medicine, University of Catania, Italy
Celotta Gabriella
- Department of Internal Medicine and Systemic Pathology, Medical Angiology Section, Italy
Pennisi Giuseppe
- Department of Internal Medicine and Systemic Pathology, Medical Angiology Section, Italy
Anzaldi Massimiliano
- Department of Internal Medicine and Systemic Pathology, Medical Angiology Section, Italy

Received 11 April 2005; received in revised form 30 August 2005; accepted 14 October 2005. published online 01 February 2006.

Abstract

Objective

To investigate the effects of propionyl l-carnitine (PLC) on clinical and functional parameters, and markers of the overall oxidation state in patients with peripheral arterial disease (PAD) associated with non-insulin-dependent diabetes mellitus (NIDDM).

Design and setting

Randomised, double-blind, clinical trial, conducted in the Unit of Medical Angiology of the University of Catania.

Patients and interventions

Seventy-four patients with NIDDM-associated PAD were treated with PLC (2g/day) or placebo for 12 months.

Main outcome measures

Ankle/brachial index (ABI) and the distance of pain-free walking were evaluated at baseline, 6 and 12 months. Malondialdehyde, 4-hydroxynonenal, oxidation time of low-density lipoproteins, and nitrite/nitrate ratio were measured as indices of the overall oxidation profiles at baseline and 12 months.

Results

In the PLC group, ABI progressively increased (0.78, 0.83, and 0.88 at 0, 6 and 12 months, respectively). The distance of pain-free walking also improved (366.4, 441.9 and 519.8m, respectively). In the placebo group, these parameters were relatively unchanged. Significant improvements in all parameters of the oxidative profile were seen in the PLC-treated group, with only minor variations observed in the placebo group.