Diabetes Research and Clinical Practice
Volume 72, Issue 3 , Pages 298-301 , June 2006

Insulinogenic indices from insulin and C-peptide: Comparison of beta-cell function from OGTT and IVGTT

  • Andrea Tura

      Affiliations

    • Metabolic Unit, ISIB-CNR, Corso Stati Uniti, 4 35127 Padova, Italy
    • ,
  • Alexandra Kautzky-Willer

      Affiliations

    • Internal Medicine III, Medical University of Vienna, Austria
    • ,
  • Giovanni Pacini

      Affiliations

    • Metabolic Unit, ISIB-CNR, Corso Stati Uniti, 4 35127 Padova, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +39 049 829 5750; fax: +39 049 829 5763.

Received 22 June 2005 ,Revised 5 September 2005 ,Accepted 14 October 2005.

References 

  1. Kahn SE. The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. Diabetologia. 2003;46:3–19
  2. Pacini G, Mari A. Methods for clinical assessment of insulin sensitivity and beta-cell function. Best Pract. Res. Clin. Endocrinol. Metab. 2003;17:305–322
  3. Seltzer HS, Allen EW, Herron AL, Brennan MT. Insulin secretion in response to glycemic stimulus: relation of delayed initial release to carbohydrate intolerance in mild diabetes mellitus. J. Clin. Invest. 1967;46:323–335
  4. Phillips DI, Clark PM, Hales CN, Osmond C. Understanding oral glucose tolerance: comparison of glucose or insulin measurements during the oral glucose tolerance test with specific measurements of insulin resistance and insulin secretion. Diabet. Med. 1994;11:286–292
  5. Hanson RL, Pratley RE, Bogardus C, Narayan KM, Roumain JM, Imperatore G, et al. Evaluation of simple indices of insulin sensitivity and insulin secretion for use in epidemiologic studies. Am. J. Epidemiol. 2000;151:190–198
  6. Stumvoll M, Mitrakou A, Pimenta W, Jenssen T, Yki-Jarvinen H, Van Haeften T, et al. Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity. Diabetes Care. 2000;23:295–301
  7. Kautzky-Willer A, Krssák M, Winzer C, Pacini G, Tura A, Farhan S, et al. Increased intramyocellular lipid concentration identifies impaired glucose metabolism in women with previous gestational diabetes. Diabetes. 2003;52:244–251
  8. Stumvoll M, Mitrakou A, Pimenta W, Jenssen T, Yki-Jarvinen H, Van Haeften T, et al. Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity. Diabetes Care. 2000;23:1440–1441
  9. Ahrén B, Pacini G. Importance of quantifying insulin secretion in relation to insulin sensitivity to accurately assess beta-cell function in clinical studies. Eur. J. Endocrinol. 2004;150:97–104
  10. Mari A, Ahrén B, Pacini G. Assessment of insulin secretion in relation to insulin resistance. Curr. Opin. Clin. Nutr. Metab. Care. 2005;8:529–533
  11. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and b-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–419
  12. Matsuda M, DeFronzo RA. Insulin sensitivity indices obtained from oral glucose tolerance testing. Comparison with the euglycemic insulin clamp. Diabetes Care. 1999;22:1462–1470
  13. Mari A, Pacini G, Murphy E, Ludvik B, Nolan JJ. A model-based method for assessing insulin sensitivity from the oral glucose tolerance test. Diabetes Care. 2001;24:539–548
  14. Mari A, Pacini G, Brazzale AR, Ahren B. Comparative evaluation of simple insulin sensitivity methods based on the oral glucose tolerance test. Diabetologia. 2005;48:748–751

PII: S0168-8227(05)00408-0

doi: 10.1016/j.diabres.2005.10.005

Diabetes Research and Clinical Practice
Volume 72, Issue 3 , Pages 298-301 , June 2006

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