Diabetes Research and Clinical Practice
Volume 72, Issue 1 , Pages 28-32, April 2006

Serum cholinesterase activity in diabetes and associated pathologies

  • Gilberto Inácio Lunkes

      Affiliations

    • Departamento de Ciências da Saúde, Universidade de Cruz Alta, Cruz Alta, RS, Brazil
  • ,
  • Franciele Stefanello

      Affiliations

    • Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, Brazil
  • ,
  • Daniéle Sausen Lunkes

      Affiliations

    • Departamento de Ciências da Saúde, Universidade de Cruz Alta, Cruz Alta, RS, Brazil
  • ,
  • Vera Maria Morsch

      Affiliations

    • Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, Brazil
  • ,
  • Maria Rosa Chitolina Schetinger

      Affiliations

    • Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, Brazil
    • Corresponding Author InformationCorresponding author. Fax: +55 5522 08031.
  • ,
  • Jamile Fabbrin Gonçalves

      Affiliations

    • Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, Brazil

Received 17 February 2005; received in revised form 24 August 2005; accepted 30 August 2005. published online 18 October 2005.

Abstract 

Serum cholinesterase activity was measured in diabetes, hypertensive and diabetic/hypertensive patients. The sample consisted of volunteer patients and was divided in a control group (n=26), type 2 diabetic group (n=16), hypertensive group (n=12) and type 2 diabetic/hypertensive group (n=26). In addition, blood glucose, cholesterol and triglyceride levels were determined. Serum cholinesterase activity in the control group was significantly lower in relation to the other groups (p<0.001). Blood glucose levels were elevated in type 2 diabetic and type 2 diabetic/hypertensive groups. In vitro studies showed increased cholinesterase activity in the presence of glucose 5–100mM or insulin 0.5–25UI (p<0.001). Cholesterol and triglycerides were at normal levels only in the control group. Possibly, a relationship exists between the increase in serum cholinesterase and the vascular complications in the diabetic patients, potentially stimulated by the levels of glycemia and dyslipidemia. Although patients were receiving different medicines, the increase in enzyme activity was similar in all groups. This enzymatic profile suggests a possible interference of the diseases in the catalytic mechanism of the serum cholinesterase enzyme.

Keywords: Cholinesterase, Human serum, Diabetes mellitus, Hypertension

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PII: S0168-8227(05)00362-1

doi:10.1016/j.diabres.2005.08.009

Diabetes Research and Clinical Practice
Volume 72, Issue 1 , Pages 28-32, April 2006