Diabetes Research and Clinical Practice
Volume 72, Issue 1 , Pages 1-5 , April 2006

Psammomys obesus (sand rat), a new animal model of non-alcoholic fatty liver disease

  • Maximo Maislos

      Affiliations

    • Atherosclerosis and Metabolism Unit, Medicine B, Department of Medicine, Soroka UMC and Ben-Gurion University FOHS, Beer-Sheva, Israel
    • Department of Medicine B, Soroka UMC and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
    • Corresponding Author InformationCorresponding author. Tel.: +972 86403042; fax: +972 86283286.
    • ,
  • Vitali Medvedovskv

      Affiliations

    • Department of Medicine B, Soroka UMC and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
    • ,
  • Ignacio Sztarkier

      Affiliations

    • Pathology Institute, Soroka UMC and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
    • ,
  • Arieh Yaari

      Affiliations

    • Liver Research Laboratory, Soroka UMC and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
    • ,
  • Emanuel Sikuler

      Affiliations

    • Department of Medicine B, Soroka UMC and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
    • Liver Research Laboratory, Soroka UMC and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel

Received 24 February 2005 ,Revised 4 April 2005 ,Accepted 6 September 2005.

References 

  1. Angulo P. Non-alcoholic fatty liver disease. NEJM. 2002;346:1221–1231
  2. Koteish A, Diehl AM. Best Pract. Res. Clin. Gastroenterol. 2002;16:679–690
  3. Reitman ML, Mason MM, Moitra J, et al. Transgenic mice lacking white fat: models for understanding human lipoathrophic diabetes. Ann. N. Y. Acad. Sci. 1999;289–296
  4. Shimomura I, Hammer RE, Richardson JA, et al. Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREP-I c in adipose tissue: model for congenital generalized lipodystrophy. Genes Dev. 1988;12:3182s–3194s
  5. Friedman JM, Leibel RL, Siegel DS, Walsh J, Bahary N. Molecular mapping of the mouse ob mutation. Genomics. 1991;11:1054–1062
  6. Rosenbaum M, Leibel RL, Hirsch J. Obesity. NEJM. 1997;337:396–407
  7. Hilzenrat N, Sikuler E, Yaari A, Maislos M. Hemodynamic characterization of the diabetic Psammomys obesus—an animal model of Type II diabetes mellitus. Is. J. Med. Sci. 1996;32:1074–1078
  8. Zoltowska M, Siv E, Delvin E, Stan S, Bar-On H, Kalman R, et al. Circulating lipoproteins and hepatic sterol metabolism in Psammomys obesus prone to obesity, hyperglycemia and hyperinsulinemia. Atherosclerosis. 2001;157:85–96
  9. Kalman R, Adler JH, Lazarovici G, Bar-On H, Ziv E. The efficiency of sand rat metabolism is responsible for development of obesity and diabetes. J. Basic Clin. Physiol. Pharmacol. 1993;4:57–68
  10. Brunt EM, Janney CG, Di Bisceglie AD, Neuschwander-Tetri BA, Bacon BR. Nonalcoholic stetohepatitis: a proposal for grading and staging the histological lesions. Am. J. Gastroenterol. 1999;94:2467–2474
  11. Collier GR, Walder K, Lewandowski P, Sanigorski A, Zimmet P. Leptin and the development of obesity in Psammomys obesus. Obes. Res. 1997;5:455–458

PII: S0168-8227(05)00360-8

doi: 10.1016/j.diabres.2005.09.007

Diabetes Research and Clinical Practice
Volume 72, Issue 1 , Pages 1-5 , April 2006

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