Diabetes Research and Clinical Practice
Volume 70, Issue 2 , Pages 183-192 , November 2005

Diabetic lipemia with eruptive xanthomatosis in a lean young female with apolipoprotein E4/4

  • Satoshi Shinozaki

      Affiliations

    • Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical School, Yakushiji 3311-1, Minamikawachi, Tochigi 329-0498, Japan
  • ,
  • Naoki Itabashi

      Affiliations

    • Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical School, Yakushiji 3311-1, Minamikawachi, Tochigi 329-0498, Japan
  • ,
  • Kumiko Rokkaku

      Affiliations

    • Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical School, Yakushiji 3311-1, Minamikawachi, Tochigi 329-0498, Japan
  • ,
  • Kenji Ichiki

      Affiliations

    • Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical School, Yakushiji 3311-1, Minamikawachi, Tochigi 329-0498, Japan
  • ,
  • Shoichiro Nagasaka

      Affiliations

    • Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical School, Yakushiji 3311-1, Minamikawachi, Tochigi 329-0498, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 285 58 7355; fax: +81 285 44 8143.
  • ,
  • Koji Okada

      Affiliations

    • Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical School, Yakushiji 3311-1, Minamikawachi, Tochigi 329-0498, Japan
  • ,
  • Mitsuo Fujimoto

      Affiliations

    • Division of Dermatology, Department of Medicine, Jichi Medical School, Yakushiji 3311-1, Minamikawachi, Tochigi 329-0498, Japan
  • ,
  • Mamitaro Ohtsuki

      Affiliations

    • Division of Dermatology, Department of Medicine, Jichi Medical School, Yakushiji 3311-1, Minamikawachi, Tochigi 329-0498, Japan
  • ,
  • Shun Ishibashi

      Affiliations

    • Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical School, Yakushiji 3311-1, Minamikawachi, Tochigi 329-0498, Japan

Received 18 October 2004 ,Revised 15 February 2005 ,Accepted 3 March 2005.

References 

  1. Champion RH, Burton JL, Burns DA, Breathnach SM. Metabolic and nutritional disorders. In: Textbook of Dermatology. sixth ed.. Oxford, UK: Blackwell Science; 1998;p. 2577–2678
  2. Kayamori Y, Nasu M, Matsumoto T, Kakutani I, Fujita S, Katayama Y, et al. Evaluation of five homogenous methods for measuring high-density lipoprotein cholesterol compared with ultracentrifugation method. J Anal Bio-Sci. 2000;23:225–232(in Japanese, Abstract in English)
  3. Nagasaka S, Ishikawa S, Nakamura T, Kawakami A, Rokkaku K, Hayashi H, et al. Association of endogenous insulin secretion and mode of therapy with body fat and serum leptin levels in diabetic subjects. Metabolism. 1998;47:1391–1396
  4. Taniguchi A, Nakai Y, Fukushima M, Kawamura H, Imura H, Nagata I, et al. Pathogenic factors responsible for glucose intolerance in patients with NIDDM. Diabetes. 1992;41:1540–1546
  5. Nagasaka S, Tokuyama K, Kusaka I, Hayashi H, Rokkaku K, Nakamura T, et al. Endogenous glucose production and glucose effectiveness in Type 2 diabetic subjects derived from stable-labeled minimal model approach. Diabetes. 1999;48:1054–1060
  6. Haffner SM, D’Agostino R, Festa A, Bergman RN, Mykkanen L, Karter A, et al. Low insulin sensitivity (Si=0) in diabetic and nondiabetic subjects in the Insulin Resistance Atherosclerosis Study. Diabetes Care. 2003;26:2796–2803
  7. Bagdade JD, Bierman EL, Porte D. Diabetic lipemia—a form of acquired fat-induced lipemia. N. Engl. J. Med. 1967;276:427–433
  8. Fajans SS, Bell GI, Polonsky KS. Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young. N. Engl. J. Med. 2001;345:971–980
  9. Chandran M, Ciaraldi T, Phillips SA, Henry RR. Adiponectin: more than just another fat cell hormone?. Diabetes Care. 2003;26:2442–2450
  10. Hotta K, Funahashi T, Arita Y, Takahashi M, Matsuda M, Okamoto Y, et al. Plasma concentrations of a novel, adipose-specific protein, adiponectin, in Type 2 diabetic patients. Arterioscler. Thromb. Vasc. Biol. 2000;20:1595–1599
  11. Yatagai T, Nagasaka S, Taniguchi A, Fukushima M, Nakamura T, Kuroe A, et al. Hypoadiponectinemia is associated with visceral fat accumulation and insulin resistance in Japanese men with Type 2 diabetes mellitus. Metabolism. 2003;52:1274–1278
  12. Howard BV. Lipoprotein metabolism in diabetes mellitus. J. Lipid Res. 1987;28:613–628
  13. Eynatten MV, Hamann A, Schneider JG, Morcos M, Humpert PM, Kreuzer J, et al. Decreased plasma lipoprotein lipase in hypoadipoectinemia. An association independent of systemic inflammation and insulin resistance. Diabetes Care. 2004;27:2925–2929
  14. Fulop M, Eder HA. Plasma triglycerides and cholesterol in diabetic ketosis. Arch. Intern. Med. 1989;19:1997–2002
  15. Karagianni C, Stabouli S, Roumeliotou K, Traeger-Synodinos J, Kavazarakis E, Gourgiotis D, et al. Severe hypertriglyceridaemia in diabetic ketoacidosis: clinical and genetic study. Diabetic Med. 2004;21:380–382
  16. Wilson PW, Schaefer EJ, Larson MG, Ordovas JM. Apoprotein E alleles and risk of coronary disease: a meta-analysis. Arterioscler. Thromb. Vasc. Biol. 1996;16:1250–1255
  17. Shimano H, Ishibashi S, Murase T, Gotohda T, Yamada N, Takaku F, et al. Plasma apolipoproteins in patients with multi-infarct dementia. Atherosclerosis. 1989;79:257–260
  18. Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science. 1993;261:921–923
  19. Ghiselli G, Schaefer EJ, Zech LA, Gregg RE, Brewer HB. Increased prevalence of apolipoprotein E4 in type V hyperlipoproteinemia. J. Clin. Invest. 1982;70:474–477
  20. Fumeron F, Rigaud D, Bertiere MC, Bardon S, Dely C, Apfelbaum M. Association of apolipoprotein epsilon 4 allele with hypertriglyceridemia in obesity. Clin Genet. 1988;34:258–264
  21. Kesaniemi YA, Ehnholm C, Miettinen TA. Intestinal cholesterol absorption efficiency in man is related to apoprotein E phenotype. J. Clin. Invest. 1987;80:578–581
  22. Kobayashi J, Saito Y, Taira K, Hikita M, Takahashi K, Bujo H, et al. Effect of apolipoprotein E3/4 phenotype on postprandial triglycerides and retinyl palmitate metabolism in plasma from hyperlipidemic subjects in Japan. Atherosclerosis. 2001;154:539–546
  23. Schreiber MM, Shapiro SI. Secondary eruptive xanthoma. Arch. Derm. 1969;100:601–603
  24. Oguni T, Takeuchi N, Shigemi F. Eruptive xanthoma in a patient with diabetes mellitus. Rinsho Derma (Tokyo). 1984;26:251–254(in Japanese)
  25. Tsukamoto K, Teramoto N, Saito R, Maruyama K. A case of diabetic xanthoma. Rinsho Derma (Tokyo). 1986;28:363–366(in Japanese)
  26. Kawano M, Sakamoto Y, Takai K, Saito T, Matsuda A, Kuzuya T, et al. An autopsy case of acute necrotizing pancreatitis following hyperlipidemia in a juvenile onset diabetic woman. J. Japan Diab. Soc. 1986;29:531–538(in Japanese, Abstract in English)
  27. Suzuki N, Okabe S, Itoh I. Diabetic xanthoma. Hifubyoshinryo. 1989;11:51–54(in Japanese)
  28. Yamada K, Mukai H, Tomizawa S, Yokoyama M. A case of diabetic xanthoma. Rinsho Derma (Tokyo). 1990;32:399–404(in Japanese)
  29. Hasegawa Y, Yasuhara M, Nishimura H. Diabetic xanthoma with peculiar clinical features. Rinshohifu. 1993;47:953–958(in Japanese)
  30. Mizoguchi Y, Toma Y, Tokuhashi K, Ochiai T, Suzuki H, Morishima T. A case of eruptive xanthoma whose eruptions were flattened only by the diet therapy of diabetes mellitus. Rinshohifu. 1991;45:791–794(in Japanese)
  31. Hashimoto A, Saitoh R. Diabetic xanthoma. Hifubyoshinryo. 1991;13:41–44(in Japanese)
  32. Nanba T, Kawakita S, Kitajima Y. Eruptive xanthoma. Rinsho Derma (Tokyo). 1996;38:1160–1161(in Japanese)
  33. Kashiwagi T, Nakamura S, Iizuka H, Kubo H. Eruptive xanthoma associated with type IV hyperlipoproteinemia. Rinsho Derma (Tokyo). 1998;40:197–200(in Japanese)
  34. Honjo S, Urushibata O, Hasegawa T, Saito R. Eruptive xanthomatosis in a patient of NIDDM. Rinsho Derma (Tokyo). 2000;42:1361–1364(in Japanese)
  35. Sato Y, Kawahara Y, Sugawara M. Eruptive xanthoma. Hifubyoshinryo. 2001;23:501–504(in Japanese)
  36. Hentges PP, Huerter CJ. Eruptive xanthomas and chest pain in the absence of coronary artery disease. Cutis. 2001;67:299–302
  37. Wakamatsu K, Miyazawa I, Gomi T. Diabetic xanthoma. Hifubyoshinryo. 2001;23:353–356(in Japanese)
  38. Nayak KR, Daly RG. Eruptive xanthomas associated with hypertriglyceridemia and new-onset diabetes mellitus. N. Engl. J. Med. 2004;350:1235
  39. Ramirez F, Gayraud B, Pereira L. Marfan syndrome: new clues to genotype-phenotype correlations. Ann. Med. 1999;31:202–207
  40. Yamamoto T, Inoue F, Matsumura A, Kinugasa A, Sawada T, Hayashi S, et al. Report of a Japanese girl with Marfan syndrome associated with insulin-dependent diabetes mellitus. Acta Paediatr. Jpn. 1992;34:551–553

PII: S0168-8227(05)00098-7

doi: 10.1016/j.diabres.2005.03.023

Diabetes Research and Clinical Practice
Volume 70, Issue 2 , Pages 183-192 , November 2005