Diabetes Research and Clinical Practice
Volume 68, Issue 2 , Pages 155-161 , May 2005

Variants of calpain-10 gene and its association with type 2 diabetes mellitus in a Chinese population

  • Bin Wu

      Affiliations

    • Division of Health Sciences, Kobe University Graduate School of Medicine, Room A203, 10-2, Tomogaoka 7-Chome Suma-Ku Kobe, Kobe 6540142, Japan
    • Division of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University School of Medicine, Guangzhou 510120, PR China
    • Corresponding Author InformationCorresponding author. Tel.: +81 78 796 4549; fax: +81 78 796 4509.
    • ,
  • Juro Takahashi

      Affiliations

    • Division of Health Sciences, Kobe University Graduate School of Medicine, Room A203, 10-2, Tomogaoka 7-Chome Suma-Ku Kobe, Kobe 6540142, Japan
    • ,
  • Mao Fu

      Affiliations

    • Division of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University School of Medicine, Guangzhou 510120, PR China
    • Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA
    • ,
  • Hua Cheng

      Affiliations

    • Division of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University School of Medicine, Guangzhou 510120, PR China
    • ,
  • Sueo Matsumura

      Affiliations

    • Division of Health Sciences, Kobe University Graduate School of Medicine, Room A203, 10-2, Tomogaoka 7-Chome Suma-Ku Kobe, Kobe 6540142, Japan
    • ,
  • Hiroshi Taniguchi

      Affiliations

    • Yamato Institute of Lifestyle-Related Diseases, 5-22 Saenba-Cho, Akashi 673 8688, Japan

Received 25 May 2004 ,Revised 2 August 2004 ,Accepted 8 September 2004.

References 

  1. King H, Aubert RE, Herman WH. Global burden of diabetes, 1995–2025. Diabetes Care. 1998;21:1414–1431
  2. American Diabetes Association Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus, Diabetes Care 20 (1997) 1183–1197.
  3. Hanis CL, Boerwinkle E, Chakraborty R, et al. A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2. Nat. Genet. 1996;13:161–166
  4. Horikawa Y, Oda N, Cox NJ, et al. Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nat. Genet. 2000;26:163–175
  5. Sreenan SK, Zhou YP, Otani K, et al. Calpains play a role in insulin secretion and action. Diabetes. 2001;50:2013–2020
  6. Baier LJ, Permana PA, Yang X, et al. A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance. J. Clin. Invest. 2000;106:R69–R73
  7. Evans JC, Frayling TM, Cassell PG, et al. Studies of the association between the gene for calpain-10 and type 2 diabetes mellitus in the United Kingdom. Am. J. Hum. Genet. 2001;69:544–552
  8. Tsai HJ, Sun GY, Weeks DE, et al. Type 2 diabetes and three calpain-10 gene polymorphisms in Samoans: no evidence of association. Am. J. Hum. Genet. 2001;69:1236–1244
  9. Horikawa Y, Oda N, Yu L, et al. Genetic variations in calpain-10 gene are not a major factor in the occurrence of type 2 diabetes in Japanese. J. Clin. Endocrinol. Metab. 2003;88:244–247
  10. Leipold H, Knofler M, Gruber C, et al. Calpain-10 haplotype combination and association with gestational diabetes mellitus. Obstet. Gynecol. 2004;103:1235–1240
  11. Lynn S, Evans JC, White C, et al. Variation in the calpain-10 gene affects blood glucose levels in the British population. Diabetes. 2002;51:247–250

PII: S0168-8227(04)00297-9

doi: 10.1016/j.diabres.2004.09.015

Diabetes Research and Clinical Practice
Volume 68, Issue 2 , Pages 155-161 , May 2005

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