Osteoclastic function is accelerated in male patients with type 2 diabetes mellitus: the preventive role of osteoclastogenesis inhibitory factor/osteoprotegerin (OCIF/OPG) on the decrease of bone mineral density

Suzuki, Kiyoshi; Kurose, Takeshi; Takizawa, Makoto; Maruyama, Masahiro; Ushikawa, Kenji; Kikuyama, Munetsugu; Sugimoto, Chieko; Seino, Yutaka; Nagamatsu, Shinya; Ishida, Hitoshi

doi:10.1016/j.diabres.2004.08.006

« Previous Next »Diabetes Research and Clinical Practice
Volume 68, Issue 2 , Pages 117-125, May 2005

Osteoclastic function is accelerated in male patients with type 2 diabetes mellitus: the preventive role of osteoclastogenesis inhibitory factor/osteoprotegerin (OCIF/OPG) on the decrease of bone mineral density

Kiyoshi Suzuki
- Third Department of Internal Medicine, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo 181-8611, Japan
- Department of Internal Medicine, Shimada Municipal Hospital, Shimada, Shizuoka 427-8502, Japan
Takeshi Kurose
- Department of Internal Medicine, Shimada Municipal Hospital, Shimada, Shizuoka 427-8502, Japan
Makoto Takizawa
- Third Department of Internal Medicine, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo 181-8611, Japan
Masahiro Maruyama
- Third Department of Internal Medicine, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo 181-8611, Japan
Kenji Ushikawa
- Third Department of Internal Medicine, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo 181-8611, Japan
Munetsugu Kikuyama
- Department of Internal Medicine, Shimada Municipal Hospital, Shimada, Shizuoka 427-8502, Japan
Chieko Sugimoto
- Department of Internal Medicine, Shimada Municipal Hospital, Shimada, Shizuoka 427-8502, Japan
Yutaka Seino
- Department of Metabolism and Clinical Nutrition, Kyoto University School of Medicine, Sakyo-ku, Kyoto 606-8507, Japan
Shinya Nagamatsu
- Second Department of Biochemistry, Kyorin University School of Medicine, Mitaka, Tokyo 181-8611, Japan
Hitoshi Ishida
- Third Department of Internal Medicine, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo 181-8611, Japan
- Corresponding author. Tel.: +81 422 47 5511x5822; fax: +81 422 76 6451.

Received 9 December 2003; received in revised form 28 July 2004; accepted 19 August 2004. published online 12 October 2004.

Abstract

To clarify the pathogenesis of altered bone metabolism in diabetic state and its underlying mechanisms, the bone mineral content and fasting levels of serum intact parathyroid hormone (i-PTH), intact osteocalcin (i-OC), tartrate-resistant acid phosphatase (TRAP) and osteoclastgenesis inhibitory factor/osteoprotegerin (OCIF/OPG) were measured in male type 2 diabetic patients and their age-matched controls. In addition, urine levels of osteoclastic markers, C-telopeptide of type I collagen (CTx), deoxypyridinoline (DPD), and N-telopeptide of type I collagen (NTx) were simultaneously determined. Serum levels of i-PTH and i-OC in diabetic patients were significantly lower than those in the controls. Conversely, serum concentrations of TRAP were significantly elevated in diabetic patients. However, no clear correlation was observed between serum i-OC and TRAP. It was also observed that urinary excretion of CTx, DPD, and NTx was significantly increased in the diabetics as compared with the controls. Unexpectedly, serum levels of OCIF/OPG tended to be higher in the diabetic group, and these values exhibited a significantly positive correlation with those of serum TRAP. There was found a significantly negative correlation between serum TRAP and bone mineral density (BMD) and also between serum OCIF/OPG and bone mineral density. It seems probable that OCIF/OPG has a suppressive role on the increased bone resorption to prevent further loss of the skeletal bone mass in type 2 diabetic patients.

Keywords: Type 2 diabetes mellitus, Intact osteocalcin, Bone resorption, Tartrate-resistant acid phosphatase (TRAP), Osteoclastogenesis inhibitory factor/osteoprotegerin (OCIF/OPG)