Diabetes Research and Clinical Practice
Volume 66 , Pages S63-S67 , December 2004

Association of Pro12Ala polymorphism of PPARγ gene with insulin resistance and related diseases

  • Mayumi Horiki

      Affiliations

    • Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    • ,
  • Hiroshi Ikegami

      Affiliations

    • Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 6 6879 3852; fax: +81 6 6879 3829.
    • ,
  • Tomomi Fujisawa

      Affiliations

    • Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    • ,
  • Yumiko Kawabata

      Affiliations

    • Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    • ,
  • Masaya Ono

      Affiliations

    • Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    • ,
  • Masanori Nishino

      Affiliations

    • Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    • ,
  • Kazuaki Shimamoto

      Affiliations

    • Second Department of Internal Medicine, Sapporo Medical University, School of Medicine, S-1 W-16, Chuo-ku, Sapporo 060-8543, Japan
    • ,
  • Toshio Ogihara

      Affiliations

    • Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Osaka, Japan

Received 30 August 2003 ,Accepted 27 September 2003.

References 

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  8. Deeb SS , Fajas L , Nemoto M , et al.   A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity . Nat. Genet. . 1998;20:284–287
  9. Masugi J , Tamori Y , Mori H , Koike Y , Kasuga M . Inhibitory effect of a proline-to alanine substitution at codon 12 of peroxisome proliferator-activated receptor-γ2 on thiazolidinedione-induced adipogenesis . Biochem. Biophys. Res. Commun. . 2000;268:178–182
  10. Ek J , Andersen G , Urhammer SA , et al.   Studies of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 (PPARγ2) gene in relation to insulin sensitivity among glucose tolerant Caucasians . Diabetologia . 2001;44:1170–1176
  11. Altshuler D , Hirschhorn JN , Klannemark M , et al.   The common PPAR-gamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes . Nat. Genet. . 2000;26:76–80
  12. Mancini FP , Vaccaro O , Sabatino L , et al.   Pro12Ala substitution in the peroxisome proliferator-activated receptor-gamma2 is not associated with type 2 diabetes . Diabetes . 1999;48:1466–1468
  13. Ringel J , Engeli S , Distler A , Sharma AM . Pro12Ala missense mutation of the peroxisome proliferator activated receptor gamma and diabetes mellitus . Biochem. Biophys. Res. Commun. . 1999;254:450–453
  14. Douglas JA , Erdos MR , Watanabe RM , et al.   The peroxisome proliferator-activated receptor-gamma2 Pro12A1a variant: association with type 2 diabetes and trait differences . Diabetes . 2001;50:886–890
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PII: S0168-8227(04)00168-8

doi: 10.1016/j.diabres.2003.09.023

Diabetes Research and Clinical Practice
Volume 66 , Pages S63-S67 , December 2004

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